New York Medical College

Graduate School of Basic Medical Sciences

Program Course Descriptions

 

BIOC 1250 Biochemistry of Gene Expression (4 credits) Drs. Wu and M. Lee
(Previously offered as 246.4)

In vitro and in vivo aspects of DNA, RNA and protein synthesis are covered in depth by instructors actively doing research in each of these areas. Special emphasis is placed on methods and techniques used to address key questions in the macromolecular processes of DNA replication and repair, RNA transcription and processing, protein synthesis, and post-translational modifications. Students are introduced to principles and applications of molecular techniques and new discoveries in the molecular biology of eukaryotes. Students are provided with a comprehensive reading list. Lectures: 4 hrs/wk. Letter-graded.

PATH 1010 Morphological and Functional Basis of Pathobiology (3 credits) Dr. Moy (Summer)(Previously offered as 401.3)

Objective-oriented, problem-solving review focused on basic aspects of normal human anatomy, histology and physiology as they relate to cellular and tissue responses occurring under pathobiological conditions. Lectures and Conferences: 3 hrs/wk. Letter-graded.

PATH 1050 Conceptual Pathology (1 credit) Dr. Godfrey
(Previously offered as 405.1)

Intensive reading and discussion of primary papers in the pathology literature with emphasis on basic concepts of pathogenesis and disease processes to complement topics covered in PATH–1080. This course is intended for Ph.D. students in other disciplines who are taking PATH–1080 as an elective. Conferences: 1 hr/wk. Letter-graded. Open to Ph.D. students only. Co-requisite: PATH–1080.

PATH 1080 Introduction to Pathology (3 credits) Dr. Moy and Staff
(Previously offered as 408.3)

An objective-oriented, problem-solving introduction to general disease processes including: cellular alterations and inflammation, genetic, immunological, nutritional and circulatory disorders; effects of infection, chemical and physical agents, blood and vascular diseases, neoplasia and aging. Topics to be covered also include analytic tools and techniques, diagnostic methodology and criteria, and recognition and control of environmental diseases. Lectures: 3 hrs/wk. Letter-graded. Prerequisite: a course in general biology. Strongly recommended: PATH–1010 or equivalent. Students may not receive credit for PATH–1080 if they have previously received credit for PATH–1410.

PATH 1090 Systemic Pathology (3 credits) Dr. Moy and Staff
(Previously offered as 409.3)

Problem-oriented study of diseases specific for various tissues (bladder, bone marrow, brain, kidney, liver, muscle, lung) and the role of environmental contamination (arsenic, asbestos, lead, mercury, allergens) in disease pathogenesis. Lectures: 3 hrs/wk. Letter-graded. Prerequisite: PATH–1080 or PATH–1410. Students cannot receive credit for PATH–1090 if they have previously received credit for PATH–1420.

PATH 1110 Fundamentals of Animal Research (3 credits) Dr. Levee
(Previously offered as 445.3)

A comprehensive course studying laboratory animals from standpoints of care, management, handling, stress, spontaneous diseases, routine clinical pathology procedures and techniques pertaining to anesthesia, injections, breeding, euthanasia and necropsy. Lectures: 3 hrs/wk. Letter-graded.

PATH 1200 Introduction to Epidemiology (3 credits) Dr. Moy
(Previously offered as 420.3)

Basic principles, methodologies and sources of data available to conduct research and monitoring activities in environmental and public health. Epidemiologic research methods and study design issues focusing on disease clusters, surveillance activity, characterization of human exposures and risk and biomarkers will be explored. Lectures: 3 hrs/wk. Letter-graded.

PATH 1410 General Pathology (6 credits) Drs. Godfrey and Zachrau
(Previously offered as 441.6)

Cellular and molecular pathology of the basic mechanisms in the structural and functional manifestation of disease are discussed in detail. The concepts of biochemistry, physiology and cell biology are utilized in developing a dynamic approach to the study of the abnormal cell and its constituents. Lectures and Conferences: 6 hrs/wk. Letter-graded. Open to Ph.D. students only.

PATH 1420 Systemic Pathology (8 credits) Drs. Godfrey and Zachrau
(Previously offered as 442.8)

An intensive study of disease by organ systems. The concepts of general pathology are applied to the analysis of specific etiology and pathogenesis. Lectures and conferences: 8 hrs/wk. Letter-graded. Prerequisite PATH–1410. Open to Ph.D. students only.

PATH 2110 Introduction to Electron Microscopy (2 credits) Dr. Chander
(Previously offered as 455.2)

Theory and practice of transmission electron microscopy applied to biological specimens. Laboratory exercises include specimen preparation, operation of a research electron microscopy and associated procedures. Lectures: 1 hr/wk. Laboratory: 2 hrs/wk. Letter-graded.

PATH 2210 Applied Environmental Science & Health (3 credits) Dr. Moy
(Previously offered as 421.3)

An overview and foundation in the diverse areas where the environment and human health interact. Ecosystem principles will be introduced as the context for discussion of environmental toxicants and their hazards, water and air systems, community noise, accident epidemiology, nutrition and public health, radiation, population dynamics, solid and hazardous waste problems, vectors, microbes and disease, environmental management and bioethics. Lectures: 3 hrs/wk. Letter-graded.

PATH 2220 Environmental Engineering and Health (3 credits) Dr. Moy
(Previously offered as 422.3)

The art and science of the protection of good health, the promotion of sound ecological thinking, the prevention of disease and injury through control of positive environmental factors, and the reduction of potential physical, biological, chemical, and radiological hazards. Environmental sanitation and engineering problems will be explored, including communicable and non-infectious diseases, water and wastewater treatment, solid waste, food protection, vector control and noise. Lectures: 3 hrs/wk. Letter-graded.

PATH 2230 Environmental Law, Policy and Management (3 credits) Dr. Moy
(Previously offered as 423.3)

Case studies and current legislative and regulatory proposals will be examined to equip students with the knowledge needed to interact with regulatory agencies and to impact the legislative process at the federal, state and local levels. The final third of the course will present an integrated approach to strategic management including total quality management. Lectures: 3 hrs/wk. Letter-graded.

PATH 2310 Environmental Toxicology (3 credits) Dr. Moy
(Previously offered as 471.3)

Pharmacological basis of toxicology, toxicity testing in animals (acute, chronic, reproductive and teratogemnicity, carcinogenicity), alternative and in vitro toxicity testing, role of epidemiology and risk assessment, regulatory and legal influences, applications in areas of pesticides, pharmaceuticals, and medical devices. Lectures: 3 hrs/wk. Letter-graded. Prerequisite: PATH–1080.

PATH 2320 Nutritional Toxicology (3 credits) Drs. Moy and Hoegler
(Previously offered as 473.3)

Examination of selected biochemical processes in a physiological framework that explain the mechanisms of action of natural, artificial and incidental toxins in food. Lectures: 3 hrs/wk. Letter graded.

PATH 2520 Air Pollution (3 credits) Dr. Moy
(Previously offered as 458.3)

An overview of atmospheric components and contaminants, sources production, detection and impact on the environment and human health. Lectures: 3 hrs/wk. Letter-graded.

PATH 2920 Health Physics in Research and Medicine (2 credits) Dr. Moy
(Previously offered as 952.2)

The first segment of the course, which is presented concurrently with course PHYS–2920, introduces general concepts of radiation physics, interaction of radiation with matter, radiation biology, dosimetry and detection systems, and regulation of radioisotope uses. The second segment explores practical aspects of health physics in the laboratory, including simple applications, instrumentation, radiation waste disposal and clinical application of radioisotopes. Students may not receive credit for both PATH–2920 and PHYS–2920. Lectures: 2 hrs/wk. Letter-graded.

PATH 7010 Directed Readings In Experimental Pathology (1-2 credits) Dr. Moy
(Previously offered as 475.x.1-2)

This course is intended for advanced students who wish to explore a particular area of experimental pathology in depth through intensive study of the relevant scientific literature. Course content will be designed to match the student’s interest with the expertise of the Experimental Pathology faculty. Topics include: biochemistry; molecular pathobiology; immunology; toxicology; cardiac, pulmonary, vascular neural or renal pathology; environmental health sciences; environmental pathology; biostatistics or epidemiology; or customized topics. Grades are based upon examinations and written and oral reports by the student. May be taken for credit more than once, with permission of the program director. Independent study. Conferences: 1-2 hrs/wk. Letter-graded.

PATH 7610 Biological Safety Evaluation of Chemical Products (2 credits) Dr. Williams and Staff
(Previously offered as 461.2)

An introduction to all aspects of biological safety evaluation of chemicals prior to clinical trials with emphasis on regulatory considerations including: acute, subacute and chronic toxicity in small and large laboratory animals; reproductive performance and teratology in rodents and lagomorphs; in vitro and in vivo mutagenicity assays; special toxicities and their mechanisms as they bear on regulatory decision-making; comparative toxicokinetics. Lecture: 30 hrs. Pass/Fail Prerequisite: M.D., Ph.D., D.V.M. or permission of instructor.

PATH 7620 Acute and Subchronic Toxicity (4 credits) Dr. Iatropoulos and Staff
(Previously offered as 462.4)

Design of single and multiple dose studies of up to 3 month duration as part of pre-clinical safety assessment of chemical substances. This course also includes laboratory hours. Lectures and Laboratory: 4 hrs/wk. Letter-graded. Prerequisite: M.D., Ph.D., D.V.M. or permission of instructor.

PATH 7630 Chronic Toxicity and Carcinogenicity (3 credits) Dr. Iatropoulos and Staff
(Previously offered as 463.3)

Design of chronic studies for the purpose of studying chronic effects of chemical substances including carcinogenicity. This course also includes laboratory hours. Lecture and Laboratory: 3 hrs/wk. Letter-graded. Prerequisite: M.D., Ph.D., D.V.M. or permission of instructor.

PATH 7640 Mutagenic Effect of Chemical Products (4 credits) Dr. Iatropoulos and Staff
(Previously offered as 464.4)

Design of in vitro and in vivo assays for the purpose of studying DNA effects, mutations, and elastogenicity elicited by chemical substances. This course also includes laboratory hours. Lecture and Laboratory: 4 hrs/wk. Letter-graded. Prerequisite: M.D., Ph.D., D.V.M. or permission of instructor.

PATH 7660 Reproductive Performance and Teratology (3 credits) Dr. Iatropoulos and Staff
(Previously offered as 466.3)

Design of assays and studies to detect interference with reproductive performance and teratogenic potential of chemical substances. This course also includes laboratory hours. Lecture and Laboratory: 3 hrs/wk. Letter-graded. Prerequisite: M.D., Ph.D., D.V.M. or permission of instructor.

PATH 7670 Mechanisms of Chemical Toxicity (3 credits) Dr. Iatropoulos and Staff
(Previously offered as 467.3)

Pathogenesis of chemically induced injury and limits of adaptation of various tissues in both man and laboratory animals. This course also includes laboratory hours. Lecture and Laboratory: 3 hrs/wk. Letter-graded. Prerequisite: M.D., Ph.D., D.V.M. or permission of instructor.

PATH 7680 Advanced Comparative Toxicokinetics (3 credits) Dr. Iatropoulos and Staff
(Previously offered as 468.3)

Adsorption, distribution, metabolism, excretion and overall tissue response to toxic substances on the comparative level of man versus laboratory animals. This course also includes laboratory hours. Lectures and Laboratory: 3 hrs/wk. Letter-graded. Prerequisite: M.D., Ph.D., D.V.M. or permission of the instructor.

PATH 7690 Diagnostic Problems and Methods in Drug-Induced Diseases (3 credits) Dr. Iatropoulos and Staff
(Previously offered as 469.3)

A detailed presentation of advanced topics in iatrogenic illness. This course also includes laboratory hours. Lectures and Laboratory: 3 hrs/wk. Letter-graded. Prerequisite: M.D., Ph.D., D.V.M. or permission of instructor.

PATH 7710 Introduction to Toxicological Pathology (3 credits) Dr. Iatropoulos and Staff
(Previously offered as 413.3)

General principles of pathologic changes elicited by chemical substances or physical devices/processes to which man or other species are exposed by design or adventitiously. This course also includes laboratory hours. Lectures and Laboratory: 3 hrs/wk. Letter-graded. Prerequisite: M.D., Ph.D., D.V.M. or permission of instructor.

PATH 7720 Regulatory Experimental Pathology (3 credits) Dr. Iatropoulos and Staff
(Previously offered as 414.3)

Principles and considerations in experimental pathology when safety assessment of chemical and physical products has to be tested as part of their registration. This course also includes laboratory hours. Lecture and Laboratory: 3 hrs/wk. Letter-graded. Prerequisite: M.D., Ph.D., D.V.M. or permission of instructor, PATH–7710.

PATH 8010 Journal Club (1 credits) Dr. Godfrey
(Previously offered as 490.1)

Students present critical appraisals of published research papers dealing with topics of current importance in experimental pathology. Seminar: 1 hr/wk. Pass/Fail. Must be taken each semester by Ph.D. students.

PATH 8400 Internship in Environmental Sciences and Health (2 credits) Dr. Moy
(Previously offered as 425.2)

The internship is composed of several components including workshops, an overview program in environmental health practice, a “shadow” program at OSHA and an environmental corporate law practice followed by an internship project carried out in an acceptable professional environmental context. Internship: hours to be arranged. Pass/Fail.

PATH 8600 Techniques in Experimental Pathology (1 credit) Dr. Godfrey
(Previously offered as 460.1)

Through demonstrations and lectures, students learn the theory and practice of laboratory techniques and instrumentation used in experimental pathology, tissue and cell culture, chromatography and electrophoresis, molecular genetics, electron microscopy, immunochemistry, immunoassay, and spectrophotometry. Lectures: 1 hr/wk. Pass/Fail. Prerequisite: Permission of instructor.

PATH 9110 Experimental Pathology Laboratory (1 credit) Dr. Godfrey
(Previously offered as 452.3)

Laboratory rotations in departmental laboratories for first-year Ph.D. students. Guided involvement in active laboratory research and directed readings in the relevant scientific literature. Research: hours to be arranged. Pass/Fail. Open to Ph.D. students only. Must be taken and completed twice.

PATH 9750 Master’s Literature Review (1 credit) Dr. Moy
(Previously offered as 497.1)

Library literature review paper summarizing the concepts and research in the field of experimental pathology. Selection of topic and preparation of paper is carried out under the guidance of a faculty advisor. Independent study. Pass/Fail. Required for Master’s degree, Plan A.

PATH 9800 Master’s Thesis Research (1-5 credits) Dr. Moy
(Previously offered as 498.1-5)

Laboratory research project carried out under the guidance of a faculty advisor and leading to submission and defense of a thesis. Thesis research: hours to be arranged. Pass/Fail. May be taken multiple times, but only five credits may be counted against Plan B Master’s degree requirements.

PATH 9850 Master’s Thesis (1 credit) Dr. Moy
(Previously offered as 495.1)

Thesis describing background, rationale and investigation of an original research project. Independent study. Pass/Fail. Required for Master’s degree, Plan B

PATH 9900 Doctoral Dissertation Research Dr. Godfrey
(Previously offered as 499.1-15)

Laboratory research project to be carried out under the guidance of a faculty advisor leading to submission and defense of a doctoral dissertation. Thesis research: hours to be arranged. Pass/Fail. May be taken multiple times for a total of 15 credits. Open to Ph.D. students only.