Chemical Safety Assessment:
Contributions of Toxicological Pathology and Mechanistic Investigations

Organized by:
Gary M. Williams, M.D.
Professor of Pathology
New York Medical College

Contact: Kathy Woodley
Tel: 914-594-3084Fax: 914-594-4163

E-mail: Kathy_Woodley@nymc.edu

Click here for Proceeding published in Toxicologic Pathology

P R O G R A M
_____________________________________________________________

Monday September 22, 2003

9:00-9:05 Dean Ralph A. O'Connell, M.D.
Provost and Dean, School of Medicine New York Medical College
Welcoming remarks

9:05-9:30 Gary M. Williams, M.D.
Professor of Pathology, Director, Environmental Pathology and Toxicology
Thresholds for chemical carcinogens

9:30-10:00 Abigail Jacobs, Ph.D.
Supervisory Pharmacologist/Associate Director of Pharmacology, Division of Dermatologic and Dental Drug Products, FDA
CDER photo safety guidance for industry

10:00-10:30 D. Reid Patterson, D.V.M., Ph.D.
Vice President, Global Preclinical Safety Abbott Laboratories
Genomic strategies in drug candidate selection  

10:30-11:00 Break

11:00-11:30 Jack A. Reynolds, D.V.M. Ph.D.
Vice President Global Preclinical Safety Abbott Laboratories
An integrated approach assess- ment of to the hepatotoxicity: Reduction of "omics"and new technologies to practice

11:30-12:00 Russell Cattley, V.M.D., Ph.D.
Senior Veterinary Pathologist, Amgen, Inc
Peroxisome proliferators and receptor-mediated carcinogenesis

12:00-1:30 Lunch

1:30-2:00 Emanuel Rubin, M.D.
Chairman, Dept. of Pathology, Anatomy and Cell Biology, Thomas Jefferson University
Drug hepatotoxicity: the great impersonator

2:30-3:00 Lois Lehman-McKeeman, Ph.D.
Research Fellow Bristol-Meyers Squibb
Metabonomic applications in predictive and mechanistic toxicology

3:00-3:30 Robert R. Maronpot, D.V.M.
Chief, Laboratory of Experimental Pathology
National Institute of Environmental Health Sciences
Magnetic resonance microscopy as applied to toxicologic pathology

3:30-4:00 Break

4:00-4:30 John L. O'Donoghue,V.M.D., Ph.D.
Director, Health & Environmental Laboratories, Eastman Kodak Company
The use of computerized tools during product development

4:30-5:00 Bruce McCullough, D.V.M., Ph.D.
Head, Drug Safety Evaluation, US Aventis Pharmaceuticals, Inc.
Bioimaging for toxicologic pathology - innovations and challenges

Tuesday September 23, 2003

9:00-9:30 Jorge Naciff, Ph.D.
Senior Scientist, Procter and Gamble
Gene expression profiles as predictors of chemical exposure: analysis of chemicals with estrogenic activity, an example

9:30-10:00 Charles C. Capen, D.V.M., Ph.D.
Distinguished University Professor, Department of Veterinary Biosciences, The Ohio State University
Mechanisms of Hormone-mediated Carcinogenesis of the Ovary

10:00-10:30 Samuel M. Cohen, M.D., Ph.D.
Professor and Chair, Pathology and Microbiology, University of Nebraska Medical Center
Carcinogenesis: of mice and men  

10:30-11:00 Break

11:00-11:30 Robert Kroes, D.V.M., Ph.D.
Director, Institute for Risk Assessment Sciences, The Netherlands
Structure-based thresholds of toxicological concern (TTC)

11:30-12:00 Dr. Karl Zech
Director of Pharmaco-Kinetics/Drug Metabolism, Altana Pharma AG
Species differences in nasal toxicity

12:00-1:30 Lunch

1:30-2:00 Mary Ellen Cosenza, Ph.D.
Director of Toxicology, Amgen Inc.
Toxicity testing of biotechnology products

2:00-2:30 Tohru Inoue, M.D., Ph.D.
Director, Center for Biological Safety and Research National Institute of Health Sciences, Japan
Mechanisms of benzene-induced hematotoxicity and leukemogenicity: c-DNA microarray analyses using mouse bone marrow tissue

2:30-3:00 Gerald L. Fisher, Ph.D.
Senior Vice President Drug Safety & Metabolism, Wyeth Research
Gastric tumors in rodents treated with proton pump inhibitors

3:00-3:30 James S. MacDonald, Ph.D.
Executive Vice President of Drug Safety and Metabolism, Schering-Plough Research Institute
Toxicology of HMG CoA reductase inhibitors: prediction of human risk

3:30-4:00 Break

4:00-4:30 Hugh E. Black, DVM, Ph.D.
President Hugh E. Black and Associates, Inc
Development of a toxicity profile for a new chemical entity

4:30-5:00 Fred Silva, M.D.
Executive Director US and Canadian Academy of Pathology
Chemical-induced nephropathy

5:00-5:30 Bernie M. Wagner, M.D.
Emeritus Research Professor of Pathology, New York University Medical Center
Returning to the future: toxicological pathology in the 21st century