New York Medical College

Charles T. Stier, Ph.D.

Associate Professor of Pharmacology

Charles Stier

Email:

charles_stier@nymc.edu

Address:

Department of Pharmacology
Basic Sciences Building
New York Medical College
Valhalla, NY 10595

Professional Interests:

Dr. Stier’s research activities over the past two decades have been supported by grants from the National Institutes of Health, the American Heart Association, and the pharmaceutical industry. He has published over 70 papers on various vascular and renal mechanisms relevant to the control of blood pressure in normotensive and hypertensive settings. Dr. Stier has gained national and international recognition for establishing that pharmacological interventions that interfere with the activity of the renin-angiotensin-aldosterone system protect against development of end organ damage in stroke prone spontaneously hypertensive rats, via a mechanism that does not depend on lowering of blood pressure. Recent research studies in Dr. Stier’s laboratory have focused on the interaction of obesity and hypertension in the production of target organ damage and the role of lipid mediators in these pathological events.

Education Profile:

Post Graduate Studies  

Graduate Degree:   Ph.D.

Graduate Degree Institution:   College of Physicians and Surgeons of Columbia University

Undergraduate Institution:   State University of New York at Stony Brook

Selected Bibliography:

Rocha, R., P.N Chander, K. Khanna, A. Zuckerman and C.T. Stier, Jr. Mineralocorticoid blockade reduces vascular injury in stroke-prone hypertensive rats. Hypertension. 31:451-458, 1998.

Rocha, R., P.N. Chander, A. Zuckerman and C.T. Stier, Jr. Role of aldosterone in renal vascular injury in stroke-prone hypertensive rats. Hypertension. 33:232-237, 1999.

Rocha, R., C.T. Stier, Jr, I. Kifor, M.R. Ochoa-Maya, H.G. Rennke and G.H. Williams, G.K. Adler. Aldosterone: A mediator of myocardial necrosis and renal arteriopathy. Endocrinology. 141:3871-3878, 2000.

Stier, C.T., Jr., P.N. Chander and R. Rocha. Aldosterone as a mediator of cardiovascular injury. Cardiology in Review. 10(2):97-106, 2002.

Botros, F.T., M.L. Schwartzman, C.T. Stier, Jr., A.I. Goodman and N. Abraham. Increase in heme oxygenase-1 levels ameliorates renovascular hypertension. Kidney International 68(6):2745-2755, 2005.

Stier, C.T., Jr. Osteopontin in patients with primary aldosteronism. American Journal of Hypertension. 19(3):298-299, 2006.

Sepehrdad, R., W.H. Frishman, C.T. Stier, Jr. and D.A. Sica. Direct inhibition of renin as a cardiovascular pharmacotherapy: Focus on Aliskiren. Cardiology in Review. 15(5):242-256, 2007.

Li, J., M.A. Carroll, P.N. Chander, J.R. Falck, B. Sangras and C.T. Stier, Jr. Soluble epoxide hydrolase inhibitor, AUDA, prevents early salt-sensitive hypertension. Frontiers in Bioscience. 13:3480-3487, 2008.

Chun, T-Y., P.N. Chander, J-W. Kim, J.H. Pratt and C.T. Stier, Jr. Aldosterone, but not angiotensin II, increases profibrotic factors in kidney of adrenalectomized stroke-prone spontaneously hypertensive rats. Am J Physiol Endocrinol Metab. 295(2):E305-E312, 2008.

Sabban, E.L., N. Schilt, L.I. Serova, S.N. Masineni and C.T. Stier, Jr. Kinetics and persistence of cardiovascular and locomotor effects of immobilization stress and influence of ACTH treatment. Neuroendocrinology. 89(1):98-108, 2009.

Stier, C.T., Jr. Mineralocorticoid receptors in myocardial infarction. Hypertension. 54(6):1211-1212, 2009.

Liclican, E.L., A.B. Doumad, J. Wang, J. Li, J.R. Falck, C.T. Stier, Jr. and M.A. Carroll. Inhibition of the adenosine 2A receptor-epoxyeicosatrienoic acid pathway renders Dahl salt-resistant rats hypertensive. Hypertension. 54(6):1284-1290, 2009.

Stier, C.T., Jr. Aldosterone and angiogenesis. American Journal of Hypertension. 23(9):940, 2010.

Chen, C.C., P.L. Pedraza, S. Hao C.T. Stier and N.R. Ferreri. TNFR1 deficient mice display altered blood pressure and renal responses to Ang II infusion. American Journal of Physiology – Renal Physiology. (Accepted for publication, 8/20/2010).