New York Medical College

Dong Sun, M.D., Ph.D.

Associate Professor of Physiology

Email:

dong_sun@nymc.edu

Address:

Department of Physiology
Basic Sciences Building
New York Medical College
Valhalla, NY 10595

Professional Interests:

My research is mainly focusing on the regulation of endothelial function of arterioles. In particular, endothelial compensatory mechanisms in response to an impaired endothelial nitric oxide (NO) signaling and endothelial deformation-induced initiation of NO-dependent vascular protective mechanisms are studied.

In recent years, I intensively focused my research on endothelial dysfunction of microvessels in response to vascular aging. Using isolated arterioles to assess flow-induced dilation and shear stress-induced release of NO, I demonstrated that age-associated endothelial dysfunction is characterized by an impaired NO bioavailability, due to a decreased shear stress-induced eNOS phosphorylation, an increased superoxide formation and a decreased antioxidant capacity. The increased superoxide formation in aged vessels is a consequence of eNOS uncoupling and increased expression of NADPH oxidase.

Education Profile:

Graduate Degree:   M.D., Ph.D.
Graduate Degree Institution:  XuZhou Medical College; New York Medical College.

Selected Bibliography:

Search PubMed for publications of Dong Sun