Esther L. Sabban, Ph.D.
Professor of Biochemistry and Molecular Biology
Department of Biochemistry and Molecular Biology
New York Medical College
Valhalla, NY 10595
The laboratory is focused on elucidating molecular mechanism of stress related disorders and possible therapies. While the physiological responses to stress are critical for survival, they increase the allostatic load and are associated with greater incidence of many widespread diseases, such as neuropsychiatric and cardiovascular disorders.
Current research interests:
♦ Preclinical studies on prophylactic, early intervention or treatment of post-traumatic stress disorders (PTSD) in the single prolonged stress, animal PTSD model. We were the first to provide proof of concept that intranasal delivery to the brain of neuropeptide Y or melanocortin 4 receptor antagonists prevented development of many of the PTSD associated impairments. The molecular, behavioral and neuroendocrine effects of the traumatic stress, with and without their intranasal delivery to the brain, are being investigated, with focus on key brain regions involved in mediating the stress response such as the noradrenergic center in the locus coeruleus, the hypothalamus, hippocampus, amygdala and prefrontal cortex.
♦ Molecular adaptations of peripheral and central catecholaminergic systems to acute and chronic stress exposure, and influence of estrogen. We are exploring new aspects of the regulation of adrenal medulla by stress, specifically the role of corticotrophin releasing hormone (CRH) family members and of various components of the renin-angiotensin system.
Graduate Degree: M.S., Ph.D.
Graduate Degree Institution: Hebrew University, New York University
Undergraduate Institution: Hebrew University
Serova, L., Laukova, M., Alaluf. L. G., Pucillo, L. and Sabban, E.L. (2014) Intranasal Neuropeptide Y Reverses Anxiety and Depressive-like Behavior Impaired by Single Prolonged Stress PTSD Model, European Neuropsychopharacology, 24:142-147.
Serova, L.I., Tillinger,A., Alaluf, L.G., Laukaova, M., Keegan, K. and Sabban, E.L. (2013) Single Intranasal Neuropeptide Y Infusion Attenuates Development of PTSD-Like Symptoms in Response to Traumatic Stress in Rats, Neuroscience, 236: 298-312.
Serova, L., Laukova, M., Alaluf. L. G. and Sabban, E.L. (2013) Intranasal Infusion of Melanocortin Receptor Four (MC4R) Antagonist to Rats Ameliorates Development of Depression and Anxiety Related Symptoms By Single Prolonged Stress, Behavioral Brain Research, 250:139-147.
Tillinger, A., Nostramo R., Richard Kvetnansky, R., Serova, L and Sabban, E.L. (2013) Stress-induced changes in gene expression of urocortin 2 and other CRH peptides in in rat adrenal medulla: Involvement of glucocorticoids. Journal of Neurochemistry, 125: 185-192.
Nostramo, R., Tillinger, A., Serova, L., Kvetnansky, R. and Sabban, E.L. (2013) Bradykinin B2 Receptor in the Adrenal Medulla of Male Rats and Mice: Glucocorticoid Dependent Increase with Immobilization Stress, Endocrinology, 154:3729-3738.
Nostramo, R., Tillinger, A., Saavedra, J.M,, Kumar, A., Pandey, V., Serova, L., Kvetnansky, R., and Sabban, E.L. (2012) Regulation of Angiotensin II Type 2 Receptor Gene Expression in Adrenal Medulla by Acute and Repeated Immobilization Stress. Journal of Endocrinology, 215, 291-301.
Serova, L.I. Harris, H.A., Maharjan, S. and Sabban, E.L. (2010) Modulation of Response to Stress by Estradiol Benzoate and Selective Estrogen Receptor Agonists, Journal of Endocrinology, 205: 253-262.
Maharjan, S., Serova, L.I and Sabban, E.L. (2010) Membrane-initiated Estradiol Signaling Increases Tyrosine Hydroxylase Promoter Activity with ERa in PC12 Cells. Journal of Neurochemistry, 112: 42-55.
Kvetnansky, R., Sabban, E.L. and Palkovits, M. (2009) Catecholaminergic Systems in Stress: Structural and Molecular Genetic Approaches. Physiological Reviews, 89: 535-606.
Liu, X., Serova, L., Kvetnanksy, R and Sabban, E.L. (2008) Identifying the Stress Transcriptome in the Adrenal Medulla Following Acute and Repeated Immobilization Annals New York Academy of Sciences, 1148: 1-28.
Serova, L.I., Gueorguiev, V., Cheng, S.Y. and Sabban, E.L. (2008) Adrenocorticotropic Hormone Elevates Gene Expression for Catecholamine Biosynthesis in Rat Superior Cervical Ganglia and Locus Coeruleus by an Adrenal Independent Mechanism, Neuroscience, 153: 1380-1389.
Page updated: March 18, 2014