Mario A. Inchiosa, Ph.D.
Professor of Pharmacology
Department of Pharmacology
Basic Sciences Building
New York Medical College
Valhalla, NY 10595
A major part of my research is conducted in collaboration with the Department of Anesthesiology at New York Medical College. We have been investigating a neuropathic pain syndrome known as reflex sympathetic dystrophy or, according to current terminology, complex regional pain syndrome. This syndrome sometimes develops in patients following apparent full recovery from trauma or surgery to the hand, wrist, foot or ankle. Our hypothesis is that in some patients, sensory pathways that conduct pain perception have become exaggerated or “supersensitive,” a condition believed to be induced by catecholamines (epinephrine and norepinephrine) and inflammatory cytokines. We have tested the clinical effects of the drug, phenoxybenzamine, on this syndrome; phenoxybenzamine is an older antihypertensive drug that can produce a long-term (non-competitive) block of some of the effects of catecholamines. The research is designed to discover ways of reversing the supersensitive state that causes this extremely painful syndrome.
A second area of research involves the development of a sensitive point-of-care assay to evaluate the effects of the low-molecular-weight-heparin drug, enoxaparin, in whole blood. Enoxaparin is one of several anticoagulant medications that may be used in patients who are at risk of developing venothromboemolisms. There is need for a rapid test to evaluate the adequacy of anticoagulant therapy in a clinic or private practice setting.
A third area of research relates to a long-standing concern for the dangers associated with the unregulated use of sympathomimetic agents (“food supplements” and drugs) for the treatment of obesity.
Post Graduate Studies
Graduate Degree: M.S., Ph.D.
Graduate Degree Institution: Rutger's University, University of Illinois
Undergraduate Institution: Rutger's University
Inchiosa MA Jr, Pothula S, Kubal K, Sanchala VT, Navarro I. Toward development of a point-of-care assay of enoxaparin anticoagulant activity in whole blood. (Submitted)
Inchiosa MA Jr. Experience (mostly negative) with the use of sympathomimetic agents for weight loss. J of Obesity; published online, August 12, 2010. http://www.hindawi.com/journals/jobes/2011/764584.html
Pothula S, Ediale KR, Kumar V, Sanchala VT, Inchiosa MA Jr. Oxygen delivery post-cardiopulmonary bypass may not be compromised by decreases in radial-aortic pressure gradients. Applied Cardiopulmonary Pathophysiology 14: 18-23, 2010.
Inchiosa MA Jr, Inchiosa ME. Toxicokinetics of xenobiotic and metabolite distribution and excretion. In: General and Applied Toxicology, B. Ballantyne, T. Marrs, T. Syversen (eds.), 3rd Ed., John Wiley & Sons, Ltd., Chichester, UK, 2009, pp 127-146.
Inchiosa MA Jr., Kizelshteyn G. Treatment of complex regional pain syndrome Type I with oral phenoxybenzamine: Rationale and case reports. Pain Practice 8:125-132, 2008.