New York Medical College

Thomas H. Hintze, Ph.D.

Professor and Chairman of Physiology

Email:

thomas_hintze@nymc.edu

Address:

Department of Physiology
Basic Sciences Building, Room 613
New York Medical College
Valhalla, NY 10595

 

Professional Interests:

Cardiovascular disease is the leading cause of mortality in noninsulin-dependent diabetes mellitus patients. Diabetic cardiomyopathy is associated with abnormal cardiac function, increased apoptosis and loss of cardiac mass. Mitochondrial dysfunction has a significant role in the development and complications of diabetic cardiomyopathy. Diabetes elevates oxidative stress, which contributes to mitochondrial dysfunction. Mitochondrial DNA (mtDNA) is particularly susceptible to damage, and the laboratory group has demonstrated that increased mtDNA mutations are concomitant with the oxidative stress associated with hyperglycemia. The group is examining whether diabetic-induced alterations in mitochondrial topoisomerase activity are the underlying mechanism for mtDNA damage and mitochondrial dysfunction that is antecedent to heart failure. A second project will establish whether cardiac progenitor cells are more sensitive to chronic elevations in oxidative stress than cardiomyocytes. Taking a longer view, identifying the pathology of cardiac stem cells as a consequence of diabetes will alter the clinical paradigm for the management of diabetes. It will provide a basis for development of new studies that focus on the protection of stem cells as a real target for clinical management.

Education Profile:

Post Graduate Studies  

Graduate Degree:   Ph.D.

Graduate Degree Institution:  

Undergraduate Institution:  

Selected Bibliography: