(Previously offered as 562.2)
Immunopharmacology is an area of research that continues to evolve as our understanding of human disease reveals roles for the immune system in, not only classical inflammatory diseases such as rheumatoid arthritis, asthma, allergies, and autoimmune diseases but also, hypertension, atherosclerosis, ischemic-reperfusion injury, and neurodegenerative disorders. Topics related to pharmacology as well as pharmacy and pharmaceutical sciences will provide the background for understanding the rationale for the development of novel therapeutic approaches for the treatment of human disease. This course will provide state-of-the-art information regarding the mechanisms that underlie the cellular and molecular basis of these interactions and will emphasize how uncovering mechanisms of the immune response may reveal potential targets for the treatment of diseases by novel antibody-, gene-based, or traditional pharmacological approaches. Lectures will include an overview of the cell types and key mediators involved in the innate and adaptive immune responses, the use of antibody preparations and small molecules to target chronic inflammation, cancer, influenza, and autoimmunity in selected diseases, and how diseases that are not traditionally thought of as inflammatory disorders exhibit features that include activation and infiltration of immune effector cells.
Prerequisites: Permission from the student’s graduate advisor and/or course director
Lectures: 2 hrs/wk. Letter-graded.