This is the second of three problem-based learning (PBL) courses that are designed to foster critical thinking, clinical reasoning, and evidenced-based practice for comprehensive and effective patient/client management. Students are assigned to small tutorial groups with a faculty tutor. Laboratories that take place four days each week provide the means for students to learn the psychomotor skills, associated with specific types of patient/client problems, and to raise additional cases for students to consider. One of the weekly labs is dedicated to the use of modalities. The first half of the course focuses on the individuals with neurologic pathologies. The second half addresses advanced orthopedic skills of patient/client management, with emphasis on conditions of the spine. In addition, the complexity of the cases in this course is intentionally greater than that of the cases in the first PBL course. This helps students to elaborate and build on the patient/client management skills learned in the first course.