PUBLICATIONS

PUBLICATIONS IN PEER REVIEWED JOURNALS

PUBLISHED BOOK CHAPTERS

BOOKS (EDITED AND CO-AUTHORED)

PUBLICATIONS IN PEER REVIEWED JOURNALS

1990

  1. Kunicka, J.E., Myc, A., Melamed, M.R., and Darzynkiewicz, Z.: Caffeine affects the cell cycle progression and decreases stability of DNA helix in situ in L1210 cells. Cell Tissue Kinet. 23:31-39, 1990.
  2. Kapuscinski, J., and Darzynkiewicz, Z.: Structure destabilization and condensation of nucleic acids by intercalators. Structure & Methods, Vol. 3: DNA & RNA. In: Proceedings of the 6th Conversation in the Discipline Biomolecular Stereodynamics. R.H Sarma, and M.H.Sarma, (Eds.), Adenine Press, Schenectady, N.Y., 1990, pp. 267-281.
  3. Evenson, D., and Darzynkiewicz, Z.: Acridine orange induced precipitation of mouse testicular sperm cell DNA reveals new patterns of chromatin structure. Exp. Cell Res. 187:328-334, 1990.
  4. Del Bino, G., Skierski, J.S., and Darzynkiewicz, Z.: Diverse effects of camptothecin, an inhibitor of topoisomerase I on the cell cycle of lymphocytic (L1210, MOLT-4) and myelogenous (HL-60, KG1) leukemic cells. Cancer Res. 50:5746-5750, 1990.
  5. Myc, A., DeAngelis, P., Melamed, M.R., and Darzynkiewicz, Z.: Retention of the mitochondrial probe rhodamine 123 in normal lymphocytes and leukemic cells in relation to the cell cycle. Exp. Cell Res. 192:198-202, 1990.

1991

  1. Del Bino, G., Lassota, P., and Darzynkiewicz, Z.: The S-phase cytotoxicity of camptothecin. Exp. Cell Res. 294:27-35, 1991.
  2. Lassota, P., Melamed, M.R., and Darzynkiewicz, Z.: Release of specific proteins from nuclei of HL-60 and MOLT-4 cells by antitumor drugs having affinity to nucleic acids. Biochem. Pharmacol. 41:1055-1065, 1991.
  3. Bretton P.R., Darzynkiewicz, Z., Henry, E., Kimmel, M., Fair, W.R., and Melamed, M.R.: DNA in situ sensitivity to denaturation in bladder cancer and its correlation with tumor stage. Cancer Res. 50:7912-7914, 1991.
  4. Del Bino, G., and Darzynkiewicz, Z.: Camptothecin, teniposide or m-AMSA but not mitoxantrone or doxorubicin induce degradation of nuclear DNA in S-phase of HL-60 cells. Cancer Res. 51:1165-1169, 1991.
  5. Myc, A., DeAngelis, P., Melamed, M.R., and Darzynkiewicz, Z.: Effect of Swainsonine on Il-2 receptor expression and proliferation of human lymphocytes. Clin. Exp. Immunopath. 4:406-410, 1991.
  6. Traganos, F., Kapuscinski, J., and Darzynkiewicz, Z.: Caffeine modulates the effects of DNA intercalating drugs in vitro: A flow cytometric and spectrophotometric analysis of caffeine interaction with Novantrone, doxorubicin, ellipticine and the doxorubicin analog, AD198. Cancer Res. 51:3682-3689, 1991.
  7. Traganos, F., Kaminska-Eddy, B., and Darzynkiewicz, Z.: Caffeine reverses the cytotoxic and cell kinetic effects of Novantrone (Mitoxantrone). Cell Prolif. 24:305-319, 1991.
  8. Bruno, S., Bauer, K., Crissman, H.A., and Darzynkiewicz, Z.: Changes in cell nuclei during S phase: Progressive chromatin condensation and altered expression of the proliferation-associated nuclear proteins Ki-67, p-105, cyclin/PCNA and p34. Exp. Cell Res. 196:99-106, 1991.
  9. Jakóbisiak, M., Bruno, S., Skierski, J., and Darzynkiewicz, Z.: The cell cycle specific effects of lovastatin. Proc. Natl. Acad. Sci. USA 88:3628-3632, 1991.
  10. Strife, A., Lambek, C., Perez, A., Darzynkiewicz, Z., Skierski, J., Gulati, S., Haley, J.D., Iwata, K.K., and Clarkson, B.D.: The effects of TGF-ß3 on the growth of highly enriched hematopoietic progenitor cells derived from normal human bone marrow and peripheral blood. Cancer Res. 51:4828-4836, 1991.
  11. Del Bino, G., Skierski, J., and Darzynkiewicz, Z.: The concentration-dependent diversity of effects of DNA topoisomerase I and II inhibitors on the cell cycle of HL-60 cells. Exp. Cell Res. 195:485-491, 1991.

1992

  1. Bruno, S., Ardelt, B., Skierski, J.S., Traganos, F., and Darzynkiewicz, Z.: Different effects of staurosporine, an inhibitor of protein kinases, on the cell cycle and chromatin structure of normal and leukemic lymphocytes. Cancer Res. 52:470-473, 1992.
  2. Bruno, S., and Darzynkiewicz, Z.: Cell cycle dependent expression and stability of the nuclear protein detected by Ki-67 antibody in HL-60 cells. Cell Prolif. 25:31-40, 1992.
  3. Rivas, C.I., Wisniewski, D., Strife, A., Perez, A., Lambek, C., Bruno, S., Darzynkiewicz, Z., and Clarkson, B.: Constitutive expression of p53 protein in enriched normal human marrow blast cell populations. Blood 79:1982-1986, 1992.
  4. Hotz, M.A., Del Bino, G., Lassota, P., Traganos, F., and Darzynkiewicz, Z.: Cytostatic and cytotoxic effects of the DNA topoisomerase II inhibitor, fostriecin, on human promyelocytic HL-60 and lymphocytic MOLT-4 leukemic cells. Cancer Res. 52:1530-1535, 1992.
  5. Myc, A., Traganos, F., Lara, J., Melamed, M.R., Darzynkiewicz, Z.: DNA stainability in aneuploid breast tumors: comparison of four DNA fluorochromes differing in binding properties. Cytometry 13:389-394, 1992.
  6. Bruno, S., Giaretti, W., Darzynkiewicz, Z.: Effect of camptothecin on mitogenic stimulation of human lymphocytes: Involvement of DNA topoisomerase I in cell transition from G0 to G1 phase of the cell cycle and in DNA replication. J. Cell Physiol. 151:478-486, 1992.
  7. Bruno, S., Gorczyca, W., and Darzynkiewicz, Z.: The effect of ionic strength in immunocytochemical detection of the proliferation associated nuclear antigens p120, PCNA and the protein reacting with Ki-67 antibody. Cytometry 12:496-501, 1992.
  8. Hotz, M.A., Traganos, F., and Darzynkiewicz, Z.: Changes in nuclear chromatin related to apoptosis or necrosis induced by the DNA topoisomerase II inhibitor fostriecin in MOLT-4 and HL-60 cells are revealed by altered DNA sensitivity to denaturation. Exp. Cell Res. 201:184-191, 1992.
  9. Mikulski, S.M., Viera, A., and Darzynkiewicz, Z.: Synergism between a novel amphibian oocyte ribonuclease and lovastatin in inducing cytostatic and cytotoxic effects in human lung and pancreatic carcinoma cell lines. Br. J. Cancer 66:304-310, 1992.
  10. Bruno, S., Lassota, P., Giaretti, W., Darzynkiewicz, Z.: Apoptosis of rat thymocytes triggered by prednisolone, camptothecin, or teniposide is selective to G0 cells and is prevented by inhibitors of proteases. Onc. Res. 4:29-35, 1992.
  11. §Gorczyca, W., Bruno, S., Darzynkiewicz, R.J., Gong, J., and Darzynkiewicz, Z.: DNA strand breaks occurring during apoptosis: Their early in situ detection by the terminal deoxynucleotidyl transferase and nick translation assays and prevention by serine protease inhibitors. Intl. J. Onc. 1:639-648, 1992.
  12. §Darzynkiewicz, Z., Bruno, S., Del Bino, G., Gorczyca, W., Hotz, M.A., Lassota, P., and Traganos, F.: Features of apoptotic cells measured by flow cytometry. Cytometry 13:795-808, 1992.
  13. Bruno, S., Del Bino, G., Lassota, P., Giaretti, W., and Darzynkiewicz, Z.: Inhibitors of proteases prevent endonucleolysis accompanying apoptotic cell death. Leukemia, 6:1113-1120, 1992.
  14. Del Bino, G., Bruno, S., Yi, P.N., Darzynkiewicz, Z.: Apoptotic cell death triggered by camptothecin or teniposide: The cell cycle specificity and effects of ionizing radiation. Cell Prolif. 25:537-548, 1992.
  15. Black, R.R., Bouvier, M.M., Sheu,K-F.R., Darzynkiewicz, Z. and Blass, J.P.: Presence of typical neuronal markers in serially cultured cells from adult human brain. J. Neurol. Sci., 111:104-112, 1992.
  16. Traganos, F., Ardelt, B., Halko, N.M., Bruno, S., and Darzynkiewicz, Z.: Effect of Genistein, a tyrosine kinase inhibitor, on the growth and cell cycle progression of normal human lymphocytes and human leukemic MOLT-4 and HL-60 cells. Cancer Res., 52: 6200-6208, 1992.

1993

  1. Traganos, F., Knutti-Hotz, J., Hotz, M., Gorczyca, W., Ardelt, B., and Darzynkiewicz, Z.: The protein kinase C inhibitor H7 blocks normal human lymphocyte stimulation and induces apoptosis of both normal lymphocytes and leukemic MOLT-4 cells. Intl. J. Onc. 2:47-59, 1993.
  2. Strife, A., Perez, A., Lambek, C., Wisniewski, D., Bruno, S., Darzynkiewicz, Z., and Clarkson, B. Characterization of lineage-negative blast subpopulations derived from normal and chronic myelogenous leukemia bone marrows and determination of their responsiveness to human c-kit ligand. Cancer. Res. 53:401-409, 1993.
  3. Capasso, J.M., Bruno, S., Zhang, X., Darzynkiewicz, Z. and Anversa, P.: Myocyte DNA synthesis with aging: correlation with ventricular loading in rats. J. Cell Phys. 155:635-648, 1993.
  4. Capasso, J.M., Bruno, S., Cheng, W., Li, P., Rodgers, R., Darzynkiewicz, Z., and Anversa, P.: Ventricular loading is coupled with DNA synthesis in adult cardiac myocytes after acute and chronic myocardial infarction in rats. Circulation, 71: 1379-1389, 1993.
  5. Darzynkiewicz, Z., Gorczyca, W., Lassota, P., and Traganos, F.: Altered sensitivity of DNA in situ to denaturation in apoptotic cells. Annal. N.Y. Acad. Sci. 677:334-339, 1993.
  6. Gorczyca, W., Melamed, M.R., Darzynkiewicz, Z.: Apoptosis of S phase HL-60 cells induced by DNA topoisomerase inhibitors: Detection of DNA strand breaks by flow cytometry using the in situ nick translation assay. Toxic. Lett. 67:249-258, 1993.
  7. §Gorczyca, W., Gong, J., and Darzynkiewicz, Z.: Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays. Cancer Res. 53:1945-1951, 1993. PATENT
  8. Darzynkiewicz, Z., and Melamed, M.R.: Flow cytometry and sorting: An historical perspective. Cytometry Res. 3:1-9, 1993.
  9. Gorczyca, W., Gong, J., Ardelt, B., Traganos, F., and Darzynkiewicz, Z.: The cell cycle related differences in susceptibility of HL-60 cells to apoptosis induced by various antitumor agents. Cancer Res. 53:3186-3192, 1993.
  10. Gorczyca, W., Bigman, K., Mittelman, A., Ahmed T., Gong J., Melamed, M.R., and Darzynkiewicz, Z.: Induction of DNA strand breaks associated with apoptosis during treatment of leukemias. Leukemia (Baltimore) 7: 659-670, 1993.
  11. Gorczyca, W., Traganos, F., Jesionowska, H., and Darzynkiewicz, Z.: Presence of DNA strand breaks and increased sensitivity of DNA in situ to denaturation in abnormal human sperm cells. Analogy to apoptosis of somatic cells. Exp. Cell Res. 207:202-205, 1993.
  12. Gorczyca, W., Ardelt, B., and Darzynkiewicz, Z.: Different rates of degradation of the proliferationo-associated nuclear and nucleolar antigens during apoptosis of HL-60 cells induced by DNA topoisomerase inhibitors. Int. J. Onc. 3: 627-634, 1993.
  13. Gong, J., Traganos, F., and Darzynkiewicz, Z.: Simultaneous analysis of cell cycle kinetics at two different DNA ploidy levels based on DNA content and cyclin B measurements. Cancer Res. 53:5096-5099, 1993.
  14. Traganos, F., Kapuscinski, J., Gong, J., Ardelt, B., Darzynkiewicz, R.J., and Darzynkiewicz, Z.: Caffeine prevents apoptosis and cell cycle effects induced by camptothecin or topotecan in HL-60 cells. Cancer Res. 53: 4613-4618, 1993.
  15. Strife, A., Perez, A., Lambek, C., Wisniewski, D., Bruno, S., Darzynkiewicz, Z., and Clarkson B.: Differences in the composition and in the efficiency of red cell production of normal and CML erythroid progenitor populations are highlighted by response to human c-kit ligand. Leukemia Res., 17:799-807, 1993.
  16. Gong, J., Li. X. and Darzynkiewicz Z: Different patterns of apoptosis of HL-60 cells induced by cycloheximide and camptothecin. J. Cell Physiol., 157: 263-270, 1993.
  17. Gorczyca, W., Melamed, M.R. and Darzynkiewicz, Z.: Programmed cell death (apoptosis). Patol. Pol. 44: 113-119, 1993.
  18. Gorczyca, W., Kram, A., Tuziak, T., Darzynkiewicz, Z., Melamed, M.R.:Proliferation Cell Nuclear Antigen in archival surgical specimens of malignant lymphoma and metastatic carcinoma: Immunohistochemical and flow cytometric analysis. Pat. Pol. 44:121-128, 1993.
  19. Gong, J., Traganos, F., and Darzynkiewicz, Z.: Expression of cyclins B and E in individual MOLT-4 cells and in stimulated human lymphocytes during their progression through the cell cycle. Int. J. Onc. 3:1037-1042,1993.
  20. Kapuscinski, J., Kimmel, M.: Thermodynamical model of mixed aggregation of intercalators with caffeine in aqueous solution. Biophysical Chemistry. 46:153-163, 1993

1994

  1. Blass, J.P., Markersbury, W.R., Ko, L.W., De Giorgio, L., Sheu, K.F. and Darzynkiewicz, Z.: Presence of neuronal proteins in serially cultured cells from autopsy human brain. J. Neurol. Sci., 121: 132-138, 1994.
  2. Del Bino, G., Li, X., Traganos, F., Darzynkiewicz, Z.: Altered susceptibility of differentiating HL-60 cells to apoptosis induced by antitumor drugs. Leukemia, 6: 281-288, 1994.
  3. Gorczyca, W., Tuziak, T., Kram, A., Melamed, M.R., and Darzynkiewicz, Z.: Detection of apoptosis in fine-needle aspiration biopsies by in situ end-labeling of fragmented DNA. Cytometry, 15: 169-175,1994.
  4. Gong, J., Traganos, F. and Darzynkiewicz, Z.: Use of cyclin E restriction point to map cell arrest in G1 induced by n-butyrate, cycloheximide, staurosporine, lovastatin, mimosine and quercetin. Int. J. Oncol., 4: 803-808, 1994.
  5. Garcia-Valenzuela, E., Gorczyca, W., Darzynkiewicz, Z., and Sharma, S.C.: Apoptosis in adult retinal ganglion cells after axotomy. J. Neurobiol. 25: 431-438, 1994.
  6. Hotz, M.A., Gong, J., Traganos, F., and Darzynkiewicz, Z.: Flow cytometric detection of apoptosis. Comparison of the assays of in situ DNA degradation and chromatin changes. Cytometry, 15:237-244, 1994.
  7. Gong, J., Traganos, F. and Darzynkiewicz, Z.: A selective procedure for DNA extraction from apoptotic cells applicable for gel electrophoresis and flow cytometry. Anal. Biochem., 218:314-319, 1994.
  8. Li, X., Gong, J., Feldman, E., Seiter, K., Traganos, F. and Darzynkiewicz, Z.: Apoptotic cell death during treatment of leukemias. Leukemia and Lymphoma, 13: Suppl. 1, 65-70, 1994.
  9. Lassota, P., Kazimierczuk, Z.,and Darzynkiewicz, Z.: Apoptotic death of lymphocytes upon treatment with 2-chloro-2'-deoxyadenosine (2-CdA). Arch. Immunol. & Exp. Ther. 42: 17-23, 1994.
  10. Traganos, F., Gong, J., Ardelt, B., and Darzynkiewicz, Z.: Effect of staurosporine on MOLT-4 cell progression through G2 and on cytokinesis. J. Cell Phys., 158: 535-544, 1994.
  11. Gong, J., Traganos, F. and Darzynkiewicz, Z.: Staurosporine blocks cell progression through G1 between cyclin D and cyclin E restriction points. Cancer Res., 54: 3136-3139,1994.
  12. §Li, X., Traganos, F., Melamed, M.R. and Darzynkiewicz, Z.: Detection of 5-bromo-2-deoxyuridine incorporated into DNA by labeling strand breaks induced by photolysis (SBIP). Int. J. Oncol., 4:1157-1161, 1994. PATENT
  13. Gong,., Ardelt, B., Traganos, F. and Darzynkiewicz, Z.:Unscheduled expression of cyclin B1 and cyclin E in several leukemic and solid tumor cell lines. Cancer Res., 54: 4285-4288, 1994.
  14. Li, X., Traganos, F. and Darzynkiewicz, Z.: Simultaneous analysis of DNA replication and apoptosis during treatment of HL-60 cells with camptothecin and hyperthermia and mitogen stimulation of human lymphocytes. Cancer Res., 54: 4289-4293, 1994.
  15. Li, X., Patel, B., Melamed, M.R., Darzynkiewicz, Z.: The cell cycle effects and induction of apoptosis by 5-bromouridine in cultures of human leukemic MOLT-4 and HL-60 cell lines and mitogen stimulated normal lymphocytes, Cell Prolif., 27: 307-319, 1994.
  16. Kajstura, J., Zhang, X., Reiss, K., Szoke, E., Li, P., Lagrasta, C., Cheng, W., Darzynkiewicz, Z., Olivetti, G., Anversa, P.: Myocyte cellular hyperplasia and myocyte cellular hypertrophy contribute to chronic ventricular remodeling in coronary artery narrowing induced cardiomyopathy in rats. Circulation, 74: 383-400, 1994.
  17. Black, R.S., DeGiorgio, L.A., Sheu, K-F.R., Darzynkiewicz, Z., Duffy, J.T. and Blass, J.P.: Expression of neuronal proteins in cells from normal adult brain propagated in serial culture. J. Neurochemistry. 62: 2132-2140, 1994.
  18. Gong, J., Li, X., Traganos, F. and Darzynkiewicz, Z.: Expression of G1 and G2 cyclins measured in individual cells by multiparameter flow cytometry; a new tool in the analysis of the cell cycle. Cell Prolif. 27: 357-371, 1994.
  19. Wang, Z., Dudhane, A., Orlikowsky, T., Clarke, K., Li, X., Darzynkiewicz, Z. and Hoffman, M.K.: CD4 engagement in vivo induces apoptosis in T cells. Eur. J. Immunol. 24: 1549-1552, 1994.

1995

  1. Halicka, D.H., Ardelt, B., Li, X., Melamed, M.R, and Darzynkiewicz, Z.:2-deoxy-glucose enhances sensitivity of human histiocytic U 935 cells to apoptosis induced by Tumor Necrosis Factor. Cancer Res. 55: 444-449, 1995.
  2. Gong, J., Traganos, F. and Darzynkiewicz, Z.: Expression of cyclins A, D2 and D3 in individual normal mitogen stimulated lymphocytes and in MOLT-4 leukemic cells analyzed by multiparameter flow cytometry. Leukemia, 9: 893-899, 1995.
  3. Li, X., Traganos, F., Melamed M.R. and Darzynkiewicz, Z.: Single step procedure for DNA strand break labeling. Detection of apoptosis and DNA replication. Cytometry, 20: 172-180, 1995.
  4. Bhatia, U., Danishefsky, K.,Traganos, F. and Darzynkiewicz, Z.: Induction of apoptosis and cell cycle specific change in expression of p53 in normal lymphocytes and MOLT-4 leukemic cells by nitrogen mustard. Clinical Cancer Res., 1: 873-880, 1995.
  5. Li, X., James, W.M., Traganos, F., and Darzynkiewicz, Z.: Application of biotin, digoxygenin or fluorescein conjugated deoxynucleotides to label DNA strand breaks in analysis of cell proliferation and apoptosis by flow cytometry. Biotech. Histochem. 70: 235-242, 1995.
  6. Qiao, L., Gorczyca, W., Pizzolo, J.G., Melamed, M.R. and Darzynkiewicz, Z.: Flow cytometric characterization of proliferation-associated nuclear antigen (p105) during the cell cycle in normal lymphocytes and promyelocytic leukemia cells. Anal. Quant. Cytol. Histol..,17: 183-188, 1995.
  7. Darzynkiewicz, Z.: Apoptosis in antitumor strategies: Modulation of cell cycle or differentiation. J. Cell Biochem., 58: 151-159, 1995.
  8. Murakami, T., Li, X., Gong, J., Bhatia U., Traganos, F. and Darzynkiewicz, Z.: Induction of apoptosis by 5-azacytidine. Drug concentration depenent differences in cell cycle specificity. Cancer Res., 55: 3093-3098, 1995.
  9. Gong, J., Traganos, F. and Darzynkiewicz, Z.: Threshold expression of cyclin E but not D type cyclins characterizes normal and tumor cells entering S phase. Cell Proliferation, 28: 337-346, 1995.
  10. Bhatia, U., Traganos, F., and Darzynkiewicz, Z.: Induction of cell differentiation potentiates apoptosis triggered by prior exposure to DNA damaging drugs. Cell Growth & Differentiation , 6: 937-944, 1995.
  11. Gong, J., Traganos, F. and Darzynkiewicz, Z.: Discrimination of G2 and mitotic cells by flow cytometry based on different expression of cyclins B1 and A. Exp. Cell Res., 220: 226-231, 1995.
  12. Venturelli, D., Martinez, R., Melotti, P., Casella, I., Peschle, C., Cucco C., Spaminato G., Darzynkiewicz, Z., and Calabretta B.: Overexpression of DR-nm23, a protein encoded by a member of nm23 family, inhibits granulocyte differentiation and induces apoptosis in 32Dc13 myeloid cells. Proc. Natl. Acad. Sci. USA, 92: 7435-7439, 1995.
  13. Gong, J., Traganos, F. and Darzynkiewicz, Z.: Growth imbalance and altered expression of cyclins B1, A. E and D3 in MOLT-4 cells synchronized in the cell cycle by inhibitors of DNA replication. Cell Growth & Differentiation, 6: 1485-1493, 1995.
  14. Ronai, Z., Tillotson, J.K., Traganos, F., Darzynkiewicz, Z., Conaway, C., Upadhyaya,P., and El-Bayoumy, K.: Effects of organic and inorganic selenium compounds on rat mammary tumor cells. Int. J. Cancer., 63: 428-434, 1995.
  15. Li, X. and Darzynkiewicz, Z.: Labeling DNA strand breaks with BrdUTP. Detection of apoptosis and cell proliferation. Cell Proliferation, 28: 571-579, 1995.
  16. Hara S., Tomita M. and Darzynkiewicz, Z.: A flow cytometric study of correlation between heat induced apoptosis and heat shock protein 70 in HL-60 cells. Cytometry Res., 5: 83-88, 1995.
  17. Seiter, K., Feldman, E.J., Traganos, F., Li, X., Halicka, H.D., Darzynkiewicz, Z., Lederman, C.A., Romero, M.-B. and Ahmed, T.: Phase I study on Taxol in acute leukemis: Evaluation of in vivo induction of apoptosis by Taxol. Leukemia, 9: 1961-1963, 1995.
  18. Skorski, T., Nieborowska-Skorska, M., Campbell, K., Iozzo, R.V., Zon, G., Darzynkiewicz, Z. and Calabretta, B.: Leukemia treatment in severe combined immunodeficiency mice by antisense oligonucleotides targeting cooperating oncogenes. J. Exp. Med. 182: 1645-1653, 1995
  19. Darzynkiewicz, Z., Hara, S., Murakami, T., Numa, Y. and Li, X.: Flow cytometric analysis of cell death: A critical review. Cytometry Research., 5: 1-8, 1995.

1996

  1. Li, X., Melamed, M.R. and Darzynkiewicz, Z.: Detection of apoptosis and DNA replication by differential labeling of DNA strand breaks with fluorochromes of different color. Exp. Cell Res., 222: 28-37, 1996.
  2. Hara,S., Halicka, H.D., Bruno, S., Gong, J., Traganos, F. and Darzynkiewicz, Z.: Effect of protease inhibitors on early events of apoptosis. Exp.Cell Res. 223: 372-384, 1996.
  3. §Juan, G., Gong, J., Traganos, F., and Darzynkiewicz, Z.: Unscheduled expression of cyclins D1 and D3 in human tumor cell lines. Cell Proliferation , 29, 259-266, 1996.
  4. Juan, G., Pan, W., and Darzynkiewicz, Z.:DNA segments sensitive to single strand specific nucleases are present in chromatin of mitotic cells. Exp.Cell Res.,227: 197-202, 1996.
  5. §Bruno, S., Traganos, F. and Darzynkiewicz, Z.: Cell cycle synchronizing properties of staurosporine. Meth. Cell Sci., 18: 99-107, 1996
  6. Darzynkiewicz, Z., Gong, J., Juan, G., Ardelt, B and Traganos, F.: Cytometry of cyclin proteins. Cytometry, 25: 1-13, 1996.
  7. Darzynkiewicz, Z., Bruno, S., Del Bino, G., and Traganos, F.: The cell cycle effects of camptothecin. In: The Camptothecins. From Discovery to the Patient. P. Pantazis, B.C.Giovanella, M.L.Rothenberg, Eds. Ann. N.Y. Acad. Sci. 803: 93-100, 1996.
  8. Traganos, F., Seiter, K., Halicka, H.D., and Darzynkiewicz, Z.: Induction of apoptosis by camptothecin and topotecan.In: The Camptothecins. From Discovery to the Patient. P. Pantazis, B.C.Giovanella, M.L.Rothenberg, Eds. Ann. N.Y. Acad. Sci. 803: 101-110, 1996.
  9. Gorczyca, W., Melamed, M.R.and Darzynkiewicz, Z.: Laser scanning cytometer analysis of fraction of labeled mitoses. Cell Proliferation 29: 539-548, 1996.
  10. Numa, Y., Matsudaira T., Kawamoto, K and Darzynkiewicz, Z. Induction of apoptosis in HL-60 (Human Leukemia-60) cells by MX-2 (new morpholino anthracyclin). Cytometry Res.,(Japan) 6: 65-70, 1996.
  11. Darzynkiewicz, Z.: Flow cytometric detection of apoptosis and necrosis. In: Proceedings of the Xth International Congress of Histochemistry and Cytochemistry. Kyoto, Japan. Acta Histochemica Cytochemica. Vol 29. Supplement. pp. 46-47. 1996.
  12. Murakami, T., Sasaki, K., Traganos, F. and Darzynkiewicz, Z.: Flow cytometric and laser scanning cytometric analysis of apoptosis induced by 5'azacytidine. In: Proceedings of the Xth International Congress of Histochemistry and Cytochemistry. Kyoto, Japan. Acta Histochemica Cytochemica. Vol 29. Supplement. pp. 48-49. 1996.

1997

  1. Seiter K., Feldman, E. J., Halicka, D., Traganos, F., Darzynkiewicz, Z., Lake, D., and Ahmed, T.: Phase I clinical and laboratory evaluation of topotecan and cytoarabine in patients with acute leukemia. J. Clin. Oncol., 15: 44-55, 1997.
  2. Vibhakar, R., Juan, G., Traganos, F., Darzynkiewicz, Z., and Finger, L.: Activation induced expression of human programmed death-1 gene in T-lymphocytes. Exp. Cell Res., 232: 25-28, 1997.
  3. Darzynkiewicz, Z., Juan, G., Li, X., Gorczyca, W., Murakami, T and Traganos, F.: Cytometry in cell necrobiology. Analysis of apoptosis and accidental cell death (necrosis). Cytometry 27: 1-20, 1997.

Oresteia Images (click on the picture to see inspiration of cell necrobiology in art)

  1. Gorczyca, W., Darzynkiewicz, Z. and Melamed MR: Laser scanning cytometry in pathology of solid tumors. Acta Cytologica, 41: 98-108, 1997.
  2. Halicka H.D., Seiter, K., Feldman, E.J., Traganos, F., Mittelman, A., Ahmed, T., and Darzynkiewicz, Z.: Cell cycle specificity of apoptosis during treatment of leukemias. Apoptosis, 2: 25-39, 1997.
  3. Juan, G., Li, X., and Darzynkiewicz, Z.: Correlation between DNA replication and expression of cyclins A and B1 in individual MOLT-4 cells. Cancer Res., 57: 803-807, 1997.
  4. §Haider, S. R., Juan, G., Traganos, F., and Darzynkiewicz, Z.: Immuno-separation and immuno-detection of nucleic acids with halogenated nucleotides. Exp. Cell Res., 234: 498-506, 1997. PATENT
  5. Halicka, H.D., Ardelt, B., Juan, G., Mittelman, A., Chen, S., Traganos, F., and Darzynkiewicz, Z. Apoptosis and cell cycle effects induced by extracts of the Chinese herbal preparation PC SPES. Int. J. Oncol. 11: 437-448, 1997.
  6. Gorczyca, W., Sorano, V., Juan, G., Melamed, M.R., and Darzynkiewicz, Z.: Laser scanning analysis of cyclin B1 in primary human malignancies. Modern Pathol. 10: 457-462, 1997
  7. Darzynkiewicz, Z.: Induction of apoptosis during treatment of leukemias. Relationship to the cell cycle. Acta Haematol. Pol., 28, Suppl. 2, 9-21. 1997
  8. Bedner, E., Burfeind, P., Gorczyca, W., Melamed, M.R., and Darzynkiewicz, Z.: Laser scanning cytometry distinguishes lymphocytes, monocytes and granulocytes by differences in their chromatin structure. Cytometry, 29: 191-196. 1997.
  9. Sailer, B.L., Valdez, J.G., Steinkamp, J.A., Darzynkiewicz, Z., and Crissman,. H.A.: Monitoring uptake of ellipticin and its fluorescence lifetime in relation to the cell cycle phase by flow cytometry. Exp. Cell Res., 236: 259-267, 1997.
  10. Finger LR, Pu J, Wasserman R, Vibhakar R, Louie E, Hardy RR, Burrows PD, Billips LG: The human PD-1 gene: complete cDNA, genomic organization, and developmentally regulated expression in B cell progenitors. Gene 12;203(2):253,1997

1998

  1. Deptala, A.,Halicka, H.D. Ardelt, B., Ardelt, W., Mikulski, S.M., Shogen, K., and Darzynkiewicz, Z.: Potentiation of tumor necrosis factor induced apoptosis by onconase. Int. J. Oncol., 13: 11-16, 1998
  2. §Juan, G., Traganos, F., James, W.M., Ray, J.M., Roberge, M., Sauve, D.M., Anderson, H, and Darzynkiewicz, Z.: Histone H3 phosphorylation and expression of cyclins A and B1 measured in individual cells during their progression through G2 and mitosis. Cytometry, 32: 71-77, 1998.
  3. §Juan, G., Gruenwald, S., and Darzynkiewicz, Z.: Phosphorylation of retinoblastoma susceptibility gene protein assayed in individual lymphocytes during their mitogenic stimulation. Exp. Cell Res., 239: 104-110, 1998 PATENT
  4. Hara, S., Tagawa, Y., Ayabe, H., and Darzynkiewicz, Z.: Analysis of of drug-induced apoptosis in human leukemic cell line HL-60. Gan. To. Kagaku Ryoho. (Jap) Suppl. 3: 393-399, 1998.
  5. Bedner, E., Burfeind, Hsieh,T-C, Wu, J.M, Aguero-Rosenfeld, M.A., Melamed, M.R., Horowitz, H.W., Wormser, G.P., and Darzynkiewicz, Z.: Cell cycle effects and induction of apoptosis caused by infection of HL-60 cells with human granulocytic ehrlichiosis (HGE) pathogen measured by flow and laser scanning cytometry (LSC). Cytometry, 33: 47-55, 1998.
  6. Bedner, E., Melamed, M.R., and Darzynkiewicz, Z: Time resolved kinetic reactions measured in individual cells by laser scanning cytometry (LSC) Cytometry, 33: 1-9, 1998.
  7. Juan, G., Ardelt, B., Mikulski, S.M., Shogen, K,M Ardelt, W., Mittelman, A., and Darzynkiewicz, Z.: G1 arrest of U-937 cells by onconase is associated with suppression of cyclin D3 expression, induction of p16INK4A, p21WAF1/CIP1 and p27KIP and decreased pRb phosphorylation. Leukemia, 12:1241-1248, 1998.
  8. Darzynkiewicz, Z., Bedner, E., Traganos, F.,and Murakami T.: Critical aspects in analysis of apoptosis and necrosis. Human Cell , 11: 3-12, 1998.
  9. Juan, G., and Darzynkiewicz, Z.: Phosphorylation of pRb in individual HL-60 cells during their proliferation and differentiation. Exp. Cell Res., 244: 83-92, 1998.
  10. Deptala, A., Bedner,E., Gorczyca, W., and Darzynkiewicz, Z.: Simple assay of activation of nuclear factor kappa B (NF-?B) by laser scanning cytometry (LSC). Cytometry, 33: 376-382, 1998.
  11. Mikulski, S., Viera, A., Deptala, A., Shogen, K., and Darzynkiewicz, Z.: Anti-tumor activity synergism between onconase and proteasome inhibitors. Int. J. Oncol., 13: 633-644, 1998.
  12. Feldman, E., Seiter, K., Chiao, J.W., Halicka, H.D., Traganos, F., Fatora, S.R., McMichael J., Baskind, P., Goff, H., Beer, M, Ahmed, T., and Darzynkiewicz, Z.: In vitro and clinical evaluation of a human chorionic gonadotrophin praparation in acute leukemia. Leukemia, 12, 1749-755, 1998.
  13. Juan, G., and  Darzynkiewicz, Z.: Phosphorylation of retinoblastoma protein (pRb) assayed in individual cells by multilaser flow cytometry. Clinical Immunol. Newsletter, 18: 89-94, 1998.
  14. Gorczyca W., Bedner, E., Burfeind, P., Darzynkiewicz, Z., and Melamed, M.R.: Analysis is apoptosis in solid tumors by laser scanning cytometry. Mod. Pathol., 11: 1-7, 1998.
  15. Gorczyca, W., Melamed, M.R., and Darzynkiewicz, Z.: Analysis of apoptosis by flow cytometry. Methods Mol. Biol., 91: 217-38, 1998.
  16. Gorczyca, W., Davidian M., Gherson, J., Ashikari R., Darzynkiewicz, Z., and Melamed, M.R.: Laser scanning cytometry quantification of estrogen receptors in breast cancer. Anal. Quant. Cytol. Histol., 20: 470-476, 1998.

1999

  1. Del Bino, G., Darzynkiewicz, Z., Degraef, C., Mosselmans, R., and Galand, P.: Comparison of methods based on annexin V binding, DNA content or TUNEL for evaluating cell death in HL-60 and adherent MCF-7 cells. Cell Prolif. 32: 25-37, 1999.
  2. §Bedner E., Li, X., Gorczyca W., Melamed, M.R., and Darzynkiewicz, Z.: Analysis of apoptosis by laser scanning cytometry. Cytometry, 35: 181-195, 1999.
  3. Tan, L., Kowalska, M.A., Romo, G., Lopez, G., Darzynkiewicz, Z., and Niewiarowski, S.: Identification and characterization of endothelial glycoprotein Ib using Viper venom proteins. Blood: 93: 2605-2616, 1999
  4. Juan, G.,Chang, W., Traganos, F and Darzynkiewicz, Z.: Histone H3 phosphorylation in human monocytes and during HL-60 cell differentiation. Exp. Cell Res., 246: 212-229, 1999.
  5. Darzynkiewicz, Z.: EDITORIAL: The butler did it: Search for killer(s) of Kaposi's sarcoma cells in preparations of human chorionic gonadotropin. JNCI, 91: 104-106, 1999
  6. §Bedner E., Halicka, H. D., Cheng, W., Salomon, T., Deptala, A., Gorczyca, W., Melamed, M.R. and Darzynkiewicz, Z.: High affinity binding of fluorescein isothiocyanate to eosinophils detected by laser scanning cytometry. A potential source of error in analysis of blood samples utilizing fluorescein-conjugated reagents in flow cytometry. Cytometry, 36: 77-82, 1999.
  7. §Darzynkiewicz, Z., Bedner, E., Gorczyca, W., and Melamed, M.R.: Laser scanning cytometry. A new instrumentation with many applications. Mini-Review. Exp. Cell Res., 249: 1-12, 1999.
  8. Hsieh, T.-C., Juan, G., Darzynkiewicz, Z and Wu, J.M.: Resveratrol increases nitric oxide synthase induces accumulation of p53 and p21WAF1/CIP1 and suppresses cultured bovine pulmonary artery endothelial cell proliferation by perturbing progression through S and G2. Cancer Res., 59: 2596-2601, 1999.
  9. 137.Li, X., and Darzynkiewicz, Z.:The Schrödinger's cat quandary in cell biology: Integration of live cell functional assays with measurements of fixed cells in analysis of apoptosis. Exp. Cell Res., 249: 404-412, 1999.  

 franks_cat.jpg (13637 bytes)  (click on the picture for full text .PDF)

  1. Hsieh, T-C., Burfeind, P., Laud, K., Backer, J.M., Traganos, F., Darzynkiewicz, Z. and Wu, J.M: Cell cycle and control of gene expression by resveratrol in breast carcinoma cell lines with different metastatic potential. Int. J. Oncol., 15: 245-252, 1999.
  2. Deptala, A., Li,X., Bedner, E., Cheng, W., Traganos, F., and Darzynkiewicz, Z.: Differences in induction of p53, p21WAF1/CIP1 and apoptosis in relation to cell cycle phase of MCF-7 cells treated with camptothecin. Int. J. Oncol., 15: 861-871, 1999.
  3. Deptala, A., Halicka, H.D., Salomon, T., Gorczyca, W., Seiter, K., Feldman, E.J., Traganos, F. and Darzynkiewicz, Z: Malignancy: a new approach to the analysis of apoptosis in the leukemic subpopulations by flow cytometry using a CD45 gating strategy. Hematol. 4: 113-121, 1999.

2000

  1. Seiter K, Feldman EJ, Halicka DH, Deptala A, Traganos F, Burke HB, Hoand A, Goff H, Pozzuoli M, Kancherla R, Darzynkiewicz Z, Ahmaed T: Clinical and laboratory evaluation of all-trans retinoic acid modulation of chemotherapy in patients with acute myelogenous leukaemia. Br J Haematol.,: 108: 40-47, 2000.
  2. Li X, Darzynkiewicz: Cleavage of Poly(ADP-Ribose) Polymerase measured in situ in individual cells: Relationship to DNA fragmentation and cell cycle position during apoptosis. Exp Cell Res., 255:125-132, 2000.
  3. Kajstura, J., Pertoldi, B., Leri, A., Beltrami, C-A., Deptala, A., Darzynkiewicz, Z. and Anversa, P.: Telomere shortening: an in vivo marker of myocyte replication and aging. Am. J. Pathol.,  156: 813-819, 2000.
  4. Lin, C-W., Darzynkiewicz, Z., Li, X., Traganos, F., Bedner, E. and Tse-Dinh, Y-C., Differential expression of human topoisomerase III alpha during the cell cycle progression in HL-60 leukemia cells and human peripheral blood lymphocytes. Exp Cell Res.,  256:225-236, 2000.
  5. Albino, A.P., Juan, G., Traganos, F., Reinart, L., Connolly, J., Rose, D.P., and Darzynkiewicz, Z.: G1 arrest of melanoma cells by docosahexaenoic acid (omaga-3 fatty acid) is associated with decreased pRB phosphorylation. Cancer Res., (60: 4139-4145, 2000.
  6. Halicka, H. D., Murakami, T., Papageorgio,C.N., Mittelman, A., Mikulski, S.M., Shogen, K., and Darzynkiewicz, Z.: Induction of differentiation of leukemic (HL-60) or prostate cancer (LNCaP, JCA-1) cells potentiates frequency of apoptosis triggered by onconase Cell Prolif., 33: 407-417, 2000.
  7. Chen, S., Deptala, A., Hsieh, T.-C., Wang, X., Ruan, Q., Traganos, F., and Darzynkiewicz, Z.,: Effects of herbal preparation PC-SPES and its active flavonoid component baicalin on androgen receptor, cell cycle and apoptosis of prostate cancer lines. Cell Prolif. (submitted)
  8. Darzynkiewicz, Z. Preclinical and clinical development of cyclin-dependent kinase modulators. Correspondence letter. JNCI, 92: 1184-1185, 2000. 
  9. Bedner, E., Ruan,Q. Chen, S., Kamentsky, L.A., and Darzynkiewicz, Z. Multiparameter analysis of progeny of individual cells in clonogenicity assays by laser scanning cytometry (LSC). Cytometry, 40: 271-279, 2000.
  10. Li, X., Du, L., and Darzynkiewicz, Z.: During apoptosis of HL-60 and U-937 cells caspases are activated independently of dissipation of mitochondrial electrochemical potential. Exp Cell Res., 257:290-297, 2000.
  11. Bedner, E., Li, X., Kunicki, J., and Darzynkiewicz, Z. Translocation of Bax to mitochondria during apoptosis measured by laser scanning cytometry. Cytometry, 41: 83-88, 2000.
  12. Bedner, E., Smolewski, P., Amstad, P., and Darzynkiewicz, Z. Activation of caspases measured in situ by binding of fluorochrome labeled inhibitors of caspases (FLICA): Correlation with DNA fragmentation. Exp. Cell Res., 259: 308-313, 2000. 
  13. Darzynkiewicz, Z., Traganos, F., Wu, J.M., and Chen, S. Chinese herbal mixture PC SPES in treatment of prostate cancer. A review. Int. J. Oncol. 17: 729-736, 2000.
  14. DiPietrantonio, A.M., Hsieh, T.-C., Juan, G., Traganos, F., Darzynkiewicz, Z., and Wu, J., Fenretinide-induced caspase-3 activity involves increased protein stability in mechanism distinct from reactive oxygen elevation. Cancer Res., 60:4331-4335, 2000.
  15. Zhang, J-C., Claffey, K., Sakthivel, R., Darzynkiewicz, Z., Shaw, D.E., Leal, J., Wang, Y-C., Lu, F-M., and McCrae, K.R. Two-chain high molecular weight kininogen induces epithelial cell apoptosis and inhibits angiogenesis: partial activity within domain 5. FASEB J., 14: 2589-2600, 2000.
  16. Bedner, E., Du, L., Traganos, F., and Darzynkiewicz, Z. Caffeine dissociates complexes between DNA and intercalating dyes. Application for bleaching fluorochrome-stained cells for their subsequent re-staining and analysis by laser scanning cytometry. Cytometry, 42:38-45, 2001.
  17. Abdel-Moneim, I., Melamed, M.R., Darzynkiewicz, Z., and Gorczyca, W.: Proliferation and apoptosis in solid tumors. Analysis by laser scanning cytometry. Anal. Quant. Cytol. Histol., 22: 393-397, 2000.
  18. Dobrucki, J., and Darzynkiewicz, Z. Chromatin condensation and sensitivity of DNA in situ to denaturation during cell cycle and apoptosis. A confocal microscopy study. Micron, 32:645-652, 2001. 
  19. Halicka, H.D., Bedner, E., and Darzynkiewicz, Z. Segregation of RNA and separate packaging of DNA and RNA in apoptotic bodies during apoptosis. Exp. Cell Res., 260: 248-256, 2000.
  20. Weisberger, J., Wu, C., Liu, M.D., Wong, J.Y.L., Melamed, M., R., Darzynkiewicz, Z., and Gorczyca, W. Differential diagnosis of malignant lymphomas and related disorder by specific pattern of expression of immunophenotype markers revealed by multiparameter flow cytometry. A review. Int. J. Oncol. 17: 1165-1177, 2000.
  21. Darzynkiewicz, Z., Bedner, E., and Smolewski, P.: Applications of cytometry in analysis of cell cycle and apoptosis. Seminars in Hematology, 38: 179-193, 2001.
  22. Smolewski, P., Bedner, E., Du, L., Hsieh, T.-T., Wu, J.M. and Darzynkiewicz, Z. Detection of caspases activation by fluorochrome labeled inhibitors (FLICA). Multiparameter analysis by laser scanning cytometry. Cytometry , 44:73-82, 2001.
  23. Nair, J., Traganos, F., and Tse-Dingh, Y.-K.: Differential effect of camptothecin treatment on topoisomerase II alpha expression in ML-1 and HL-60 leukemia cell lines. Anticancer Res., 20: 4183-4188, 2000.
  24. Ardelt, B., Kunicki, J., Traganos, F. and Darzynkiewicz, Z.: Chlorophyllin protects cells from the cytostatic and cytotoxic effects of quinacrine mustard but not of nitrogen mustard. Int. J. Oncol., 18: 845-853,2001.
  25. Darzynkiewicz, Z., Smolewski, P., and Bedner, E.: Use of flow- and laser scanning- cytometry to study mechanisms regulating cell cycle and controlling cell death. Clin. Lab. Medicine [in press]
  26. Darzynkiewicz, Z., Bedner, E., and Smolewski, P.: In situ detection of DNA strand breaks in analysis of apoptosis by flow- and laser scanning- cytometry. Meth. Molec. Biology. [in press]
  27. Blagosklonny, M.V., Darzynkiewicz, Z., Swain, S., and Figg, W.D. Effects of flavopiridol on p53, p21, and paclitaxel-induced cell death: comparison with DNA damage-mediated effects. Exp. Cell Res. (submitted)
  28. Smolewski, P., Ruan, Q., Vellon, L., and Darzynkiewicz, Z., The micronuclei assay by laser scanning cytometry. Cytometry, (in press)
  29. Deptala, A., Bedner, E., and Darzynkiewicz, Z. Unique analytical capabilities of laser scanning cytometer (LSC) that complement flow cytometry. Folia Histochem. Cytobiol., 39: 87-98, 2001.
  30. Williams, J.L., Borgo, S., Hasan, I., Castillo, E., Traganos, F., and Rigas, B. Nitric oxide-releasing non-steroidal anti-inflamatory drugs (NSAIDs) alter the kinetics of human colon cancer cell lines more effectively than traditional NSAIDs: implications for colon cancer prevention. Cancer Res., 61:3285-3267, 2001. 
  31. Deptala, A,., Bedner, E., and Darzynkiewicz, Z. Unique analytical capabilities of laser scanning cytometry (LSC) that complement flow cytometry. Folia Histochem. Cytobiol., 39: 87-89, 2001. 
  32. Darzynkiewicz, Z., Bedner, E., and Smolewski, P., New approaches in analysis of apoptosis by cytometry. Acta Haematol. Polon. 32 (Suppl 1), 77-79, 2001.
  33. Smolewski, P., Bedner, E., Gorczyca, W., and Darzynkiewicz, Z.: "Liquidless" cell staining by dye diffusion from gels and analysis by laser scanning cytometry. Potential application at micro-gravity conditions in space. Cytometry, 44: (in press)
  34. Moog-Lutz, C., Guibal, F.C., Cave-Riant, F., Smolewski, P., Di Gioia, Y., Darzynkiewicz, Z., Lutz, P.G., and Cayre, Y.E. ASB-2 induces commitment and promotes retinoic acid-induced differentiation in myeloid leukemia cells. J. Exp. Med. (submitted)
  35. Darzynkiewicz, Z., Bedner, E., and Smolewski, P. Analysis of apoptosis by laser scanning cytometry. Meth. Pharmacol. Toxicol., (in press)
  36. Hsieh, T.-C., Kunicki, J., Darzynkiewicz, Z. and Wu, J.M. Effects of extracts of Trametes Versicolor (I'm YunityTM) on cell cycle progression and expression of interleukins 1beta, -6 and -8 in promyelocytic HL-60 leukemic cells and mitogenically stimulated and nonstimulated human lymphocytes. J. Alternat. Med., (in press).
  37. Smolewski, P., Grabarek, J., Kamentsky, L.A., and Darzynkiewicz, Z., Bivariate analysis of cellular DNA vs RNA content by laser scanning cytometry using the product of signal subtraction (Differential Fluorescence; DF) as a separate parameter. Cytometry. (in press)
  38. Darzynkiewicz, Z., Bedner, E., Smolewski, P., B..W. Lee and Johnson, G.L. Detection of caspases activation in situ by fluorochrome-labeled inhibitors of caspases.(FLICA). Meth. Molec. Biol., (in press).
  39. Gorczyca, W., Smolewski, P., Ardelt, B., Ita, M., Melamed, M.R., and Darzynkiewicz, Z. Morphometry of nucleoli and expression of nucleolin analyzed by laser scanning cytometry in mitogenically stimulated lymphocytes. Cytometry (submitted)
  40. Du, L., Smolewski, P., Bedner, E., Traganos, F., and Darzynkiewicz.: Selective protection of mitogenically stimulated human lymphocytes but not leukemic cells from cytosine arabinoside-induced apoptosis by LY294002, a phosphoinositol- kinase inhibitor. Int. J. Oncol., (in press) 
  41. Smolewski, P., Grabarek, J., Halicka, H.D., and Darzynkiewicz, Z.: Assay of caspases activation in situ combined with probing plasma membrane integrity detects three distinct stages of apoptosis. J. Immunol. Meth. (submitted)
  42. Smolewski, P., Grabarek, J., Phelps D., Darzynkiewicz Z: Stathmo-apoptosis: arresting apoptosis by fluorochrome-labeled inhibitor of caspases. Int J Oncol (in press)