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Course Descriptions

PATH  1010      Morphological and Functional Basis of Pathobiology   (3 credits)                      Dr. Moy                   (Summer)

Objective-oriented, problem-solving review focused on basic aspects of normal human anatomy, histology and physiology as they relate to cellular and tissue responses occurring under pathobiological conditions.   Lectures and Conferences: 3 hrs/wk.  Letter-graded.

PATH  1050      Conceptual Pathology                                 (1 credit)                      Dr. Godfrey

Intensive reading and discussion of primary papers in the pathology literature with emphasis on basic concepts of pathogenesis and disease processes to complement topics covered in PATH–1080.  This course is intended for PhD. students in other disciplines who are taking PATH–1080 as an elective.  Conferences: 1 hr/wk.  Letter-graded.  Open to Ph.D. students only.  Co-requisite: PATH–1080.

PATH  1080      Introduction to Pathology                                (3 credits)          Dr. Moy and staff

An objective-oriented, problem-solving introduction to general disease processes including: cellular alterations and inflammation, genetic, immunological, nutritional and circulatory disorders; effects of infection, chemical and physical agents, blood and vascular diseases, neoplasia and aging.  Topics to be covered also include analytic tools and techniques, diagnostic methodology and criteria, and recognition and control of environmental diseases.  Lectures: 3 hrs/wk.  Letter-graded.  Prerequisite: a course in general biology.  PATH-1010 or its equivalent is recommended.  Students may not receive credit for PATH–1080 if they have previously received credit for PATH–1410.

PATH  1090      Systemic Pathology                             (3 credits)                      Dr. Moy and staff

Problem-oriented study of diseases specific for various tissues (bladder, bone marrow, brain, kidney, liver, muscle, lung) and the role of environmental contamination (arsenic, asbestos, lead, mercury, allergens) in disease pathogenesis.  Lectures: 3 hrs/wk.  Letter-graded.  Prerequisite: PATH–1080 or PATH–1410.  Students cannot receive credit for PATH–1090 if they have previously received credit for PATH–1420. 

PATH  1110      Fundamentals of Animal Research                        (3 credits)                Dr. Levee

A comprehensive course studying laboratory animals from standpoints of care, management, handling, stress, spontaneous diseases, routine clinical pathology procedures and techniques pertaining to anesthesia, injections, breeding, euthanasia and necropsy.  Lectures: 3 hrs/wk.  Letter-graded.

PATH  1200      Introduction to Epidemiology                          (3 credits)                      Dr. Moy

Basic principles, methodologies and sources of data available to conduct research and monitoring activities in environmental and public health.  Epidemiologic research methods and study design issues focusing on disease clusters, surveillance activity, characterization of human exposures and risk and biomarkers will be explored.  Lectures: 3 hrs/wk.  Letter-graded.

PATH  1410      General  Pathology                          (6 credits)                Drs. Godfrey and Zachrau

Cellular and molecular pathology of the basic mechanisms in the structural and functional manifestation of disease are discussed in detail.  The concepts of biochemistry, physiology and cell biology are utilized in developing a dynamic approach to the study of the abnormal cell and its constituents.   Lectures and Conferences:  6 hrs/wk. Letter-graded.  Open to Ph.D. students only. 

PATH  1420      Systemic Pathology                          (8 credits)                Drs. Godfrey and Zachrau

An intensive study of disease by organ systems.  The concepts of general pathology are applied to the analysis of specific etiology and pathogenesis.  Lectures and conferences: 8 hrs/wk.  Letter-graded.  Prerequisite PATH–1410.  Open to Ph.D. students only.    

PATH  2210      Applied Environmental Science & Health                    (3 credits)          Dr. Moy

An overview and foundation in the diverse areas where the environment and human health interact.  Ecosystem principles will be introduced as the context for discussion of environmental toxicants and their hazards, water and air systems, community noise, accident epidemiology, nutrition and public health, radiation, population dynamics, solid and hazardous waste problems, vectors, microbes and disease, environmental management and bioethics.  Lectures: 3 hrs/wk.  Letter-graded.

PATH  2220      Environmental Engineering and Health                       (3 credits)          Dr. Moy

The art and science of the protection of good health, the promotion of sound ecological thinking, the prevention of disease and injury through control of positive environmental factors, and the reduction of potential physical, biological, chemical, and radiological hazards.  Environmental sanitation and engineering problems will be explored, including communicable and non-infectious diseases, water and wastewater treatment, solid waste, food protection, vector control and noise.  Lectures: 3 hrs/wk.  Letter-graded.

PATH  2230      Environmental Law, Policy and Management                   (3 credits)          Dr. Moy

Case studies and current legislative and regulatory proposals will be examined to equip students with the knowledge needed to interact with regulatory agencies and to impact the legislative process at the federal, state and local levels.  The final third of the course will present an integrated approach to strategic management including total quality management.  Lectures: 3 hrs/wk.  Letter-graded.

PATH  2310      Environmental Toxicology                               (3 credits)                Dr. Moy

Pharmacological basis of toxicology, toxicity testing in animals (acute, chronic, reproductive and teratogenicity, carcinogenicity), alternative and in vitro toxicity testing, role of epidemiology and risk assessment, regulatory and legal influences, applications in areas of pesticides, pharmaceuticals, and medical devices.  Lectures: 3 hrs/wk.  Letter-graded.  Prerequisite: PATH–1080 or PATH-1410.

PATH  2320      Nutritional Toxicology                               (3 credits)                      Drs. Moy

Examination of selected biochemical processes in a physiological framework that explain the mechanisms of action of natural, artificial and incidental toxins in food.  Lectures: 3 hrs/wk.  Letter graded. 

PATH 2520       Air Pollution                                              (3 credits)                      Dr. Moy

An overview of atmospheric components and contaminants, sources production, detection and impact on the environment and human health.  Lectures:  3 hrs/wk.  Letter-graded.

PATH  2920      Health Physics in Research and Medicine                      (2 credits)             Dr. Moy

The first segment of the course, which is presented concurrently with course PHYS–2920, introduces general concepts of radiation physics, interaction of radiation with matter, radiation biology, dosimetry and detection systems, and regulation of radioisotope uses.  The second segment explores practical aspects of health physics in the laboratory, including simple applications, instrumentation, radiation waste disposal and clinical application of radioisotopes.  Students may not receive credit for both PATH–2920 and PHYS–2920.  Lectures: 2 hrs/wk.  Letter-graded.

PATH  7010      Directed Readings In Experimental Pathology                   (1-2 credits)        Dr. Moy

This course is intended for advanced students who wish to explore a particular area of experimental pathology in depth through intensive study of the relevant scientific literature.  Course content will be designed to match the student’s interest with the expertise of the Experimental Pathology faculty.  Topics include:  biochemistry; molecular pathobiology; immunology; toxicology; cardiac, pulmonary, vascular neural or renal pathology; environmental health sciences; environmental pathology; biostatistics or epidemiology; or customized topics. Grades are based upon examinations and written and oral reports by the student.  May be taken for credit more than once, with permission of the program director.  Independent study.  Conferences: 1-2 hrs/wk.  Letter-graded.

PATH  7610      Biological Safety Evaluation of Chemical Products           (2 credits)       Dr. Williams

An introduction to all aspects of biological safety evaluation of chemicals prior to clinical trials with emphasis on regulatory considerations including: acute, subacute and chronic toxicity in small and large laboratory animals; reproductive performance and teratology in rodents and lagomorphs; in vitro and in vivo mutagenicity assays; special toxicities and their mechanisms as they bear on regulatory decision-making; comparative toxicokinetics.  Lecture: 30 hrs.  Pass/Fail Prerequisite: M.D., Ph.D., D.V.M. or permission of instructor.

N.B.  Courses PATH-7620 through PATH-7720 are available only to students matriculated in the Plan E Master’s track. 

PATH 7620       Acute and Subchronic Toxicity                        (4 credits)          Dr. Iatropoulos

Design of single and multiple dose studies of up to 3 month duration as part of pre-clinical safety assessment of chemical substances.  This course also includes laboratory hours.  Lectures and Laboratory: 4 hrs/wk.  Letter-graded. Prerequisite: M.D., Ph.D., D.V.M. or permission of instructor.

PATH  7630      Chronic Toxicity and Carcinogenicity                       (3 credits)          Dr. Iatropoulos

Design of chronic studies for the purpose of studying chronic effects of chemical substances including carcinogenicity.  This course also includes laboratory hours.  Lecture and Laboratory:  3 hrs/wk.  Letter-graded.  Prerequisite: M.D., Ph.D., D.V.M. or permission of instructor.

PATH  7640      Mutagenic Effect of Chemical Products                    (4 credits)          Dr. Iatropoulos

Design of in vitro and in vivo assays for the purpose of studying DNA effects, mutations, and elastogenicity elicited by chemical substances.  This course also includes laboratory hours.  Lecture and Laboratory: 4 hrs/wk.  Letter-graded.  Prerequisite: M.D., Ph.D., D.V.M. or permission of instructor.

PATH  7660      Reproductive Performance and Teratology                 (3 credits)       Dr. Iatropoulos

Design of assays and studies to detect interference with reproductive performance and teratogenic potential of chemical substances.  This course also includes laboratory hours.  Lecture and Laboratory: 3 hrs/wk. Letter-graded.  Prerequisite: M.D., Ph.D., D.V.M. or permission of instructor.

PATH  7670      Mechanisms of Chemical Toxicity                               (3 credits)       Dr. Iatropoulos

Pathogenesis of chemically induced injury and limits of adaptation of various tissues in both man and laboratory animals.  This course also includes laboratory hours.  Lecture and Laboratory: 3 hrs/wk.  Letter-graded.  Prerequisite: M.D., Ph.D., D.V.M. or permission of instructor.

PATH  7680      Advanced Comparative Toxicokinetics                       (3 credits)       Dr. Iatropoulos

Adsorption, distribution, metabolism, excretion and overall tissue response to toxic substances on the comparative level of man versus laboratory animals.  This course also includes laboratory hours.  Lectures and Laboratory: 3 hrs/wk.  Letter-graded.  Prerequisite: M.D., Ph.D., D.V.M. or permission of the instructor.

PATH  7690      Diagnostic Problems and Methods in Drug-Induced Diseases            

                                                                                                            (3 credits)       Dr. Iatropoulos

A detailed presentation of advanced topics in iatrogenic illness.  This course also includes laboratory hours.  Lectures and Laboratory: 3 hrs/wk.  Letter-graded.  Prerequisite: M.D., Ph.D., D.V.M. or permission of instructor.

PATH  7710      Introduction to Toxicological Pathology                      (3 credits)       Dr. Iatropoulos

General principles of pathologic changes elicited by chemical substances or physical devices/processes to which man or other species are exposed by design or adventitiously.  This course also includes laboratory hours.   Lectures and Laboratory: 3 hrs/wk.  Letter-graded.  Prerequisite: M.D., Ph.D., D.V.M. or permission of instructor.

PATH  7720      Regulatory Experimental Pathology                            (3 credits)       Dr. Iatropoulos

Principles and considerations in experimental pathology when safety assessment of chemical and physical products has to be tested as part of their registration.  This course also includes laboratory hours.  Lecture and Laboratory: 3 hrs/wk.  Letter-graded.  Prerequisite: M.D., Ph.D., D.V.M. or permission of instructor, PATH–7710.

PATH  8010      Journal Club                                                    (1 credit)                 Dr. Godfrey

Students present critical appraisals of published research papers dealing with topics of current importance in experimental pathology.  Seminar: 1 hr/wk.  Pass/Fail.  Must be taken each semester by Ph.D. students.

PATH  8400      Internship in Environmental Sciences and Health             (2 credits)          Dr. Moy

The internship is composed of several components including workshops, an overview program in environmental health practice, a “shadow” program at OSHA and an environmental corporate law practice followed by an internship project carried out in an acceptable professional environmental context.  Internship: hours to be arranged.  Pass/Fail.

PATH 8600       Techniques in Experimental Pathology                       (1 credit)           Dr. Godfrey

Through demonstrations and lectures, students learn the theory and practice of laboratory techniques and instrumentation used in experimental pathology, tissue and cell culture, chromatography and electrophoresis, molecular genetics, electron microscopy, immunochemistry, immunoassay, and spectrophotometry.  Lectures: 1 hr/wk.  Pass/Fail.  Prerequisite: Permission of instructor. 

PATH  9110      Research Rotation in Experimental Pathology            (1 credit)           Dr. Godfrey

Laboratory rotations in departmental laboratories for first-year Ph.D. students.  Guided involvement in active laboratory research and directed readings in the relevant scientific literature.  Research: hours to be arranged.  Graded on a Satisfactory / Unsatisfactory basis.    Open to Ph.D. students only.  Must be taken and completed twice.

PATH 9200       Research Techniques in Experimental Pathology             (1 credit)          Dr. Godfrey

Research training undertaken by Ph.D. students after choosing a dissertation sponsor, but before achieving candidacy.  Research.  Graded on a Satisfactory / Unsatisfactory basis.  May be taken multiple times.  Open to Ph.D. students only.

PATH 9700       Master’s Independent Study                            (1 credit)                       Dr. Moy

Candidates for the Master of Science degree (Plan A, C, D and E) in the Experimental Pathology program may use this course to receive credit for reading and analyzing the scientific literature they will use in writing their mandatory Master’s Literature Review (PATH-9750).  Students enrolled in PATH-9700 should provide their faculty advisor with frequent and regular updates on their progress.  Independent study.  Graded on a Satisfactory / Unsatisfactory basis.  Open to Master’s students only.

PATH  9750      Master’s Literature Review                              (1 credit)                       Dr. Moy

This course is entered on the student’s transcript when the Master’s Literature Review is approved by the faculty review committee and submitted in final form to the Graduate School.  Required for Master’s degree under Plans A, C, D and E.  Independent study.  Pass only.

PATH  9800      Master’s Thesis Research                                (1-5 credits)                   Dr. Moy

Candidates for the Master of Science degree (Plan B) in Experimental Pathology may elect to conduct a research project under the supervision of a faculty member.  Submission of an acceptable final report summarizing results is required (PATH–9850).  Thesis Research.  Pass/Fail.  May  be taken multiple times, for one to five credits per term, but only five credits can be applied towards program requirements.  Open to Master’s students only.

PATH  9850      Master’s Thesis                                                (0 credits)                      Dr. Moy

This course is entered on the student’s transcript when the Master’s Thesis is approved by the faculty review committee and submitted in final form to the Graduate School.  Required for “Plan B” Master’s degree.  Independent study.  Pass only.

PATH  9900      Doctoral Dissertation Research                         (1 credit)          Dr. Godfrey and staff

Laboratory research project to be carried out under the guidance of a faculty advisor leading to submission and defense of a doctoral dissertation.  Thesis research: hours to be arranged.  Graded on a Satisfactory / Unsatisfactory basis.  May be taken multiple times.  Open to Ph.D. students only.

   

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