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Stephen Adler, M.D.

Stephen Adler

Professor of Medicine and Physiology

Email: Stephen@nymc.edu

Phone: (914) 493-7701

Address:

Division of Nephrology
Westchester Medical Center
Macy Pavilion
Valhalla, NY 10595

Personal Profile:

Dr. Adler joined the Division of Nephrology of New York Medical College in 1986 as an Associate Professor after spending four years at the University of Washington in Seattle with the noted nephrologist Dr. William G. Couser. Dr. Adler has been active in basic research, clinical trials, division administration, teaching and patient care. Currently, Dr. Adler oversees the faculty practice and operations of the division and is the Chief of Nephrology for Children's and Women's Physicians of Westchester, a large faculty practice group on campus. He has a joint appointment in the Department of Physiology and has collaborated with Dr. T. Hintze, Chairman of Physiology, on studies of renal NO production in disease and aging.

Professional Interests:

Dr. Adler serves as a key clinical faculty in the nephrology fellowship program and participates in didactic teaching of fellows in addition to acting as a teaching attending on the inpatient consultative service 7-8 weeks every year. He has done investigative work in immunologic kidney disease, the role of oxidant stress in aging and hypertension and more recently clinical trials involving control of bone/mineral metabolism in dialysis patients and prevention of progression of Polycystic Kidney Disease. He also oversees the research program for the nephrology fellows.

Education Profile:

Post Graduate Studies: Mount Sinai Medical Center, New York, NY-Internal Medicine, Boston University Medical Center, Boston, MA-Nephrology
Graduate Degree: M.D.
Graduate Degree Institution: N.Y.U. School of Medicine
Undergraduate Institution: Cornell University

Selected Bibliography:

1. Adler S: Inhibition of rat glomerular visceral epithelial cell growth by heparin. Am J Physiol 255:F781 F786, 1988

2. Adler S, Eng, B: Reversal of inhibition of rat glomerular epithelial cell growth by growth factors. Am J Pathol 136:557 563, 1990

3. Adler S, Chen X, Eng B: Control of rat glomerular epithelial cell growth in vitro. Kidney Int 37:1048 54, 1990

4. Adler S: Heparin alters epidermal growth factor metabolism in cultured rat glomerular epithelial cells. Am J Pathol 139:169 175, 1991

5. Adler S: Integrin receptors in the glomerulus Potential role in glomerular injury. Am J Physiol 262:F697-F704, 1992

6. Adler S, Chen X: Anti Fx1A antibody recognizes a 1 integrin on glomerular epithelial cells and inhibits adhesion and growth. Am J Physiol 262:F770-F776, 1992

7. Adler S: Characterization of glomerular epithelial cell matrix receptors. Am J Pathol 141:571-578, 1992

8. Adler S, Eng B: Integrin receptors and function on cultured glomerular endothelial cells. Kidney Int 44: 278-284, 1993

9. Adler S, Sharma R, Savin VJ, Abbi R, Eng B: Alteration of glomerular permeability to macromolecules induced by cross-linking of 1 integrin receptors. Am J Pathol 149:987-996, 1996

10. Adler S, Bollu R: Glomerular endothelial cell injury mediated by Shiga-like toxin-1. Kidney and Blood Pressure Research 21:13-21, 1998

11. Adler S, Brady H: Cell Adhesion molecules and glomerulopathies. Am J Med 107:371-386, 1999

12. Adler S, Huang H, Loke K, Xu X, Laumas A, Hintze TH: Modulation of renal oxygen consumption by nitric oxide is impaired after development of congestive heart failure in dogs. J Cardiovasc Pharmacol 37:301-9, 2001

13. Adler S, Szczech L, Qureshi A, Bollu R, Thomas-John R: Anticardiolipin antibodies are associated with stenosis of vascular access in patients receiving hemodialysis. Clin Nephrol 56:428-434, 2001

14. Adler S, Huang H, Loke KE, Xu X, Tada H, Laumas A, Hintze TH: Endothelial nitric oxide synthase plays an essential role in regulation of renal oxygen consumption by nitric oxide. Am J Physiol Renal Physiol 280:F838-F843, 2001

15. Adler S, Huang H, Xu X, Gupta S, Trochu JN, Hintze TH: Simvastatin reverses impaired regulation of renal oxygen consumption in congestive heart failure. Am J Physiol Renal Physiol 281:F802-F809, 2001

16. Adler S, Huang H, Hintze TH: Impaired regulation of renal oxygen consumption in spontaneously hypertensive rats. J Am Soc Nephrol 13:1788-1794, 2002

17. Quarles LD, Sherrard DJ, Adler S, Rosansky SJ, McCary LC, Liu W, Turner SA, Bushinsky DA: The calcimimetic AMG073 as a potential treatment for secondary hyperparathyroidism of end-stage renal disease. J Am Soc Nephrol 14:575-583, 2003

18. Adler S, Huang H, Wolin MS, Kaminski PM: Oxidant stress leads to impaired regulation of renal cortical oxygen consumption by nitric oxide in the aging kidney. J Am Soc Nephrol, 15:52-60, 2004

19. Adler S, Huang H: Oxidant Stress in Kidneys of Spontaneously Hypertensive Rats Involves both Oxidase Overexpression and Loss of Extracellular Superoxide Dismutase. Am J Physiol Renal Physiol 287:F907-F913, 2004

20. Moe SM, Cunningham J, Bommer J, Adler S, Rosansky SJ, Urena-Torres P, Albizem MB, Guo MD, Zani VJ, Goodman WG, Sprague SM: Long-term Treatment of Secondary Hyperparathyroidism with the Calcimimetic Cinacalcet HCl. Nephrol Dial Transpl 20:2186-93 2005

21. Zeng L, Xu H, Chew TL, Eng E, Sadeghi MM, Adler S, Kanwar YS, Danesh F: HMG CoA reductase inhibition modulates VEGF-induced endothelial cell hyperpermeability by preventing RhoA activation and myosin light chain phosphorylation, FASEB J 19:1845-7, 2005

22. Tanaka T, Kojima I, Ohse T, Ingelfinger JR, Adler S, Fujita T Nangaku M: Cobalt promotes angiogenesis via hypoxia-inducible factor and protects tubulointerstitium in the rat remnant-kidney. Lab Invest 85:1292-307, 2005

23. Kruger A, Sahityani R, O'Riordan E, Stewart J, Thompson C, Adler S, Garrick R, Vallance P, Goligorsky MS: Laser doppler flowmetry detection of endothelial dysfunction in end-stage renal disease patients: correlation with cardiovascular risk. Kidney Int 70:157-164, 2006

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