15 Dana Road
Basic Science Building
Rooms 205, 206, AO4
Valhalla, NY 10595
The Ballabh lab studies the pathogenesis of intraventricular hemorrhage (IVH) and evaluates neuro-protective strategies to prevent brain damage after IVH in premature infants. We have developed a model of IVH in premature rabbit pups (E29, Term=32 days), in which hemorrhage results in periventricular white matter injury and post-hemorrhagic hydrocephalus similar to that seen in human preterm survivors with IVH. We have been successful in making important breakthroughs in understanding the pathogenesis of IVH in preterm infants and in testing neuro-protective strategies to prevent brain damage after IVH in premature infants. Specifically, we have shown that celecoxib, thyroxine, or Bone morphogenetic protein inhibition restores neurologic recovery in preterm rabbits with brain hemorrhage. In addition, we are studying neurogenesis in human brain from fetuses and preterm infants in late pregnancy.
Post Graduate Studies: Neonatal Perinatal Medicine Fellowship: New York Presbyterian Hospital of Cornell University, New York, NY. Pediatric Residency: Christ Hospital Medical Center, University of Illinois, Chicago, IL
Graduate Degree: MBBS, MD (Pediatrics) from Banaras Hindu University, Varanasi, India
Board Certification: Pediatrics (1997), Neonatal-Perinatal Medicine (2001), recertification in 2009)
1. Vose LR, Vinukonda G, Jo S, Miry O, Diamond D, Korumilli R, Arshad A, Zia MT, Hu F, Kayton RJ, La Gamma EF, Bansal R, Bianco AC, Ballabh, P. Treatment with thyroxine restores myelination and clinical recovery after intraventricular hemorrhage. J Neurosci. 2013 Oct 30;33(44):17232-46
2. Malik S, Vinukonda G, Vose LR, Diamond D, Bhimavarapu BB, Hu F, Zia MT, Hevner R, Zecevic N, Ballabh P. Neurogenesis continues in the third trimester of pregnancy and is suppressed by premature birth. J Neurosci. 2013 Jan 9;33(2):411-23. PMID: 23303921
3. Dummula K, Vinukonda G, Chu P, Xing Y, Hu F, Mailk S, Csiszar A, Chua C, Mouton P, Kayton RJ, Brumberg JC, Bansal R, Ballabh P. Bone morphogenetic protein inhibition promotes Neurological recovery after intraventricular hemorrhage. J Neurosci. 2011 Aug 24;31(34):12068-82. PubMed. PMID:21865450; PubMed Central PMCID: PMC3167068.
4. Vinukonda G., Csiszar, A., Hu F, Dummula K, Pandey NK, Zia MT, Ferreri, NR, Ungvari, Z, LaGamma EF Ballabh, P. Neuroprotection in intraventricular hemorrhage by cox-2 inhibition: EP1 receptor and TNF-α are downstream mediators of brain injury. Brain 2010 Aug;133(Pt 8):2264-802.
5. Chua C, Chahboune H, Braun A, Dummula K., Chua CE, Yu J, Ungvari Z, Sherbany A, Hyder F, Ballabh P. Consequences of intraventricular hemorrhage in a rabbit pup model. Stroke 2009 Oct;40(10):3369-77.
6. Georgiadis P, Xu H, Chua C, Hu F, Collins L, Huynh C, Lagamma EF, Ballabh P. Characterization of acute brain injuries and neurobehavioral profiles in a rabbit model of germinal matrix hemorrhage. Stroke
7. Vinukonda G. Csiszar, A. Hu F, Dummula K, Pandey NK, Zia MT, Ferreri, NR, Ungvari, Z, LaGamma EF Ballabh, P. Effect of prenatal glucocorticoid on the vasculature of the developing brain. Stroke. 2010 Aug;41(8):1766-73. PubMed PMID:20616316; PubMed Central PMCID: PMC2920046.
8. Zia MT, Csiszar A, Labinskyy N, Hu F,Vinukonda G, Lagamma EF, Ungvari Z, Ballabh P. Oxidative-Nitrosative Stress in a Rabbit Pup Model of Germinal Matrix hemorrhage: Role of NAD(P)H Oxidase. Stroke 2009 Jun;40(6):2191-8. PubMed PMID:19372442; PubMed Central PMCID: PMC2726799.
9. Ballabh P, Xu H, Hu F, Xu H, Braun A, Ungvari Z. Csiszar A, Goldman S, Nedergaard M. Angiogenic inhibition reduced germinal matrix hemorrhage. Nature Medicine 2007 Apr;13(4):477-85. (Cover page article).
10. Braun A, Xu H, Kocherlakota P, Siegel D, Ungvari Z. Csiszar A , Nedergaard M, Ballabh P. Paucity of pericytes in germinal matrix vasculature. J Neurosci 2007 Oct 31; 27(44):12012-12024
Funding: RO1 and R21 grants from NINDS/NIH.