Department of Environmental Health Science
School of Health Sciences and Practice
Vosburgh Pavilion, Rm 104
Valhalla, NY 10595
Dr. Shakarjian is Assistant Professor and Program Director for the Environmental Health Science Programs at New York Medical College’s School of Health Sciences and Practice. He is instructor and course director for the M.P.H. Core Course, “Environmental Influences on Human Health.” and also is instructor for the Environmental Health Capstone Course.
Dr. Shakarjian’s research activities include investigating countermeasures against dermatological and neurological poisons. In particular, he is investigating the effects of a seizure-inducing rodenticide that has been responsible for thousands of accidental and intentional poisonings. With his collaborators, Libor Velisek, Jana Veliskova, and Patric Stanton, he is searching for the most effective treatments for the convulsant syndrome produced by this poison. His support for this project comes from the NIH CounterACT (Countermeasures Against Chemical Threats) program and the NYMC Intramural Research Support Program.
Prior to his academic career, Dr. Shakarjian spent 10 years in the pharmaceutical and small biotechnology industries where he was involved in several areas of small molecule and protein-based therapeutics R&D, including target identification and validation, assay development, candidate screening, and GLP/GCP bioanalytical studies.
Dr. Shakarjian holds a secondary appointment in the Department of Cell Biology and Anatomy. He also has an Adjunct appointment at the Rutgers/Robert Wood Johnson Medical School Department of Medicine where he maintains a collaborative relationship with that institution’s CounterACT Center of Excellence.
In the community, Dr. Shakarjian chairs the Environmental Commission in his home Borough of Milltown, NJ. Additionally, he is president of the Lawrence Brook Watershed Partnership, in a watershed that is part of the NJ DEP Watershed Management Area 9. Dr. Shakarjian has also been a long-standing affiliate of the Central Jersey Chapter of the Association for Women in Science where he coordinates their STEM scholarship program for high school senior women.
Postdoctural Fellowship: Walter Reed Army Institute of Research and the Squibb Institute of Medical Research.
Graduate Degree: Ph.D., M.A.
Graduate Degree Institution: Ph.D. Pharmacology and Toxicology
Medical College of Virginia/Virginia Commonwealth University, M.A. Pharmacology & Therapeutics SUNY at Buffalo
Undergraduate Degree: B.S. in Biochemical Pharmacology
Areas of Expertise:
Shakarjian, M.P., Ali, M. Velíšková, J., Stanton, P.K., Heck, D.E. and Velíšek, L. Combined Treatment with Diazepam and Mk-801 Provide Enhanced Protection from Tetramethylenedisulfotetramine-Induced Seizures and Lethality. FASEB J 28(1) Supplement 1143.14, 2014.
Zheng R., Heck D.E., Mishin V., Black A.T., Shakarjian M.P., Kong A.N., Laskin D.L., Laskin J.D. Modulation of keratinocyte expression of antioxidants by 4-hydroxynonenal, a lipid peroxidation end product. Toxicol Appl Pharmacol. 275(2):113-121, 2014.
Esposito D., Rathinasabapathy T., Schmidt B., Shakarjian MP.,Komarnytsky S., and Raskin I. Acceleration of cutaneous wound healing by brassinosteroids. Wound Repair Regen. 21(5):688-696, 2013.
Shakarjian, M.P., Velíšková, J., Stanton, P.K. and Velíšek, L. Differential antagonism of tetramethylenedisulfotetramine-induced seizures by agents acting at NMDA and GABAA receptors. Toxicol. Appl. Pharmacol., 265:113-121, 2012.
Heck D.E., Shakarjian M.P., Kim H.D., Laskin J.D., and Vetrano AM. Mechanisms of oxidant generation by catalase. Ann N Y Acad Sci. 1203:120-5, 2010.
Shakarjian M.P., Heck D.E., Gray J.P., Sinko, P.J., Gordon, M.K., Casillas, R.P., Heindel, N.D., Gerecke, D.R., Laskin D.L., Laskin J.D: Mechanisms Mediating the Vesicant Actions of Sulfur Mustard after Cutaneous Exposure. Toxicol Sci. 114:5-19, 2010.
Gray J.P., Gerecke D.R, Shakarjian M.P., and Casillas R.P.: Dermal Toxicity of Sulfur Mustard, in Handbook of Toxicology of Chemical Warfare Agents, Ed. by Ramesh Gupta, Elsevier: New York, 2009, pp 611-632.
Black A.T., Gray J.P., Shakarjian M.P., Laskin D.L., Heck D.E., Laskin J.D.: Distinct effects of ultraviolet B light on antioxidant expression in undifferentiated and differentiated mouse keratinocytes. Carcinogenesis 29:219-25, 2008.
Shakarjian, M.P., Bhatt, P., Gordon, M.K., Chang, Y-C., Sabourin, C.L., Casillas, R.P., Ohman-Strickland, P., Riley, D.J. and Gerecke, D.R.: Differential Expression of Matrix Metalloproteinases-2 and –9 in a Mouse Model of Sulfur Mustard Exposure. J. Appl. Tox. 26:239-246, 2006.
Keum Y.S., Han Y.H., Liew C., Kim J.H., Xu C., Yuan X., Shakarjian M.P., Chong S., and Kong A.N.: Induction of Heme Oxygenase-1 (HO-1) and NAD[P]H: Quinone Oxidoreductase 1 (NQO1) by a Phenolic Antioxidant, Butylated Hydroxyanisole (BHA) and Its Metabolite, tert-Butylhydroquinone (tBHQ) in Primary-Cultured Human and Rat Hepatocytes. Pharm Res. 23:2586-94, 2006.