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| Admissions - Programs - Registration - Events - Staff - NYMC Home |
EXPERIMENTAL PATHOLOGY PROGRAM
Program Director: Dr. Henry Godfrey, (PhD program); Dr. Fred Moy, (Master's programs)
The Department of Pathology offers programs of study and research training leading to the Master of Science and Doctor of Philosophy degrees. These programs focus on the comprehensive study of pathogenic mechanisms of disease. This knowledge, and the ability to apply it, is absolutely essential for the ultimate prevention and cure of all diseases, whatever their cause. The educational program for both the M.S. and Ph.D. degrees is designed to foster analytical problem-solving within the wide range of the basic medical sciences, with particular emphasis on the fundamental disciplines of cellular and molecular biology, biochemistry, and immunology. Research programs within the graduate programs provide a vigorous multidisciplinary milieu in which to receive laboratory training for a career in the biomedical sciences.
In addition to an M.S. track in general experimental pathology, there are three more specialized M.S. tracks. Increasing awareness of environmental degradation has led to an increased need for persons with training in environmental pathology in industry and government. A series of departmental courses examines the biological effects of environmental pollutants and their role in the pathogenesis of environmentally caused disease. These courses permit students to emphasize environmental pathology in their graduate training and form the core of the program leading to an M.S. in Experimental Pathology with emphasis on environmental pathology. A second Master’s track adds courses and practical experience related to evaluation and management of environmental pathogenic factors and leads to an M.S. in Experimental Pathology with emphasis on applied environmental science. The Department also offers a program leading to an M.S. in Experimental Pathology with an emphasis on toxicological pathology for those already holding an advanced degree (M.D., Ph.D., D.V.M., or equivalent) who require specialized training in this area. Admission to this latter program is strictly limited and highly competitive.
The doctoral program leading to the Ph.D. in Experimental Pathology allows for great flexibility in course work to suit the student’s particular interest. The hallmark of the Ph.D. is, however, laboratory training and the development of research skills to prepare the student for a career as a research scientist in the broad area of pathogenesis of human disease. A wide range of research laboratories within the Department of Pathology, the College’s Cancer Research Institute and the adjacent American Health Foundation are available for the student’s dissertation research project.
Master of Science Program
Specific Program Requirements (Hegis Code 0408)
Admission to the M.S. program with emphasis on Toxicologic Pathology is limited to applicants who already have a doctoral degree (M.D., Ph.D., D.V.M.). Submission of the Graduate Record Examination (GRE) General Test scores is required for admission to all degree programs in experimental pathology.
Elective courses are chosen in consultation with the graduate program director and faculty sponsor. PATH–8600 may be counted toward elective credit requirements in all Experimental Pathology programs. Research credits may be substituted for didactic credits in the general experimental pathology M.S. track (Plan B), but not in any of the three specialized M.S. tracks.
Master of Science with emphasis on Experimental Pathology
A minimum of 31 credits is required including either the one-credit Master’s Literature Review (Plan A) or the one credit Master’s Thesis (Plan B).
| Required Core Courses | |
| Introduction to Pathology (PATH–1080) | 3 credits |
| Systemic Pathology (PATH–1090) | 3 credits |
| Introduction to Epidemiology (PATH–1200) | 3 credits |
| Environmental Toxicology (PATH–2310) OR Toxicology (PHARM–2510) | 2 or 3 credits |
| General Biochemistry I & II (BIOC–1010, 1020) | 8 credits |
| Cell Biology (CELL–1360) | 3 credit |
| Introduction to Biostatistics (BMS–1100) OR Statistics for Basic Medical Sciences (BMS–1200) | 2 or 3 credits |
| Plan A: | |
| Electives | 4 - 6 credits |
| Master’s Literature Review (PATH–9750) | 1 credit |
TOTAL - Plan A |
31 credits |
| Plan B: | |
| Electives | 0 to 6 credits |
| Master’s Thesis Research (PATH–9800) | up to 5 credits |
| Master’s Thesis (PATH–9850) | 1 credit |
TOTAL - Plan B |
31 credits |
Master of Science with emphasis on Environmental Pathology
A minimum of 31 course credits, including a one-credit Master’s Literature Review, is required. The topic chosen for PATH–7010 may be tailored to the student’s individual needs and interests, but should be in the area of environmental pathology or environmental health science.
| Required Core Courses | |
| Introduction to Pathology (PATH–1080) | 3 credits |
| Systemic Environmental Pathology (PATH–1090) | 3 credits |
| Lectures in Histology (CELL–1320) | 3 credits |
| Laboratory in Histology (CELL–1330) | 2 credits |
| Fundamentals of Animal Research (PATH–1110) | 3 credits |
| Directed Readings in Experimental Pathology (PATH–7010) | 2 credits |
| Introduction to Biostatistics (BMS–1100) OR Statistics for Basic Medical Sciences (BMS–1200) | 2 or 3 credits |
| Introduction to Epidemiology (PATH–1200) | 3 credits |
| Environmental Toxicology (PATH–2310) OR Toxicology (PHARM–2510) | 2 or 3 credits |
| Master’s Literature Review (PATH–9750) | 1 credit |
| Electives | 5 - 7 credits |
TOTAL |
31 credits |
Master of Science with emphasis on Applied Environmental Science.
A minimum of 31 course credits, including a one-credit Master’s Literature review, is required.
| Required Core Courses | |
| Introduction to Pathology (PATH–1080) | 3 credits |
| Introduction to Epidemiology (PATH–1200) | 3 credits |
| Applied Environmental Science & Health (PATH–2210) | 3 credits |
| Environmental Engineering and Health (PATH–2220) | 3 credits |
| Environmental Law, Policy & Management (PATH–2230) | 3 credits |
| Environmental Toxicology (PATH–2310) OR Toxicology (PHARM–2510) | 2-3 credits |
| Introduction to Biostatistics (BMS–1100) OR Statistics for Basic Medical Sciences (BMS–1200) | 2 or 3 credits |
| Internship in Environmental Science (PATH–8400) | 2 credits |
| Master’s Literature Review (PATH–9750) | 1 credit |
| Electives | 7-9 credits |
TOTAL |
31 credits |
Master of Science with emphasis on Toxicologic Pathology.
A minimum of 30 course credits, including a one-credit Master’s Literature Review, is required.
| Required Core Courses | |
| Introduction to Toxicological Pathology (PATH–7710) | 3 credits |
| Regulatory Experimental Pathology (PATH–7720) | 3 credits |
| Biological Safety Evaluation of Chemical Products (PATH–7610) | 2 credits |
| Acute and Subchronic Toxicity (PATH–7620) | 4 credits |
| Chronic Toxicity and Carcinogenicity (PATH–7630) | 3 credits |
| Mutagenic Effects of Chemical Products (PATH–7640) | 4 credits |
| Reproductive Performance & Teratology (PATH–7660) | 3 credits |
| Mechanisms of Chemical Toxicity (PATH–7670) | 3 credits |
| Advanced Comparative Toxicokinetics (PATH–7680) | 3 credits |
| Journal Club (PATH–8010) | 1 credit |
| Master’s Literature Review (PATH–9750) | 1 credit |
TOTAL |
30 credits |
Doctor of Philosophy
Specific Program Requirements (Hegis Code 0408)
A minimum of 45 course credits plus 15 dissertation research credits is required. Students participate in laboratory research each semester, acquiring skills and experience for developing a program of supervised independent research for the doctoral dissertation. Journal Club (PATH–8010) is taken in each semester of residence, but is not counted toward the 45-credit degree requirement.
| Required Core Courses | |
| Cell Biology (CELL–1360) | 3 credits |
| General Biochemistry I & II (BIOC–1010, 1020) | 8 credits |
| Fundamentals of Animal Research (PATH–1110) | 3 credits |
| Experimental Pathology Laboratory (PATH–9110) | 6 credits |
| General Pathology (PATH–1410) | 6 credits |
| Systemic Pathology (PATH–1090 or PATH–1420) | 3 - 8 credits |
| Cell Physiology (PHYS–2310) OR Cell Signaling (BIOC–2630) | 2 credits |
| Introduction to Biostatistics (BMS–1100) OR Statistics for Basic Medical Sciences (BMS–1200) | 2 - 3 credits |
| Journal Club (CELL 8010) | 0 credits |
| Bioethics (BMS–2010) | 2 credits |
Electives |
0 - 6 credits |
Subtotal, course credits |
45 credits |
| Doctoral Dissertation Research (PATH-9900) | 15 credits |
TOTAL |
60 credits |
M.D./Ph.D. Candidates
Students in the M.D./Ph.D. program seeking their Ph.D. in Experimental Pathology must earn 10 credits in didactic graduate courses, including Biochemistry of Gene Expression (BIOC–1250) and Cell Biology (CELL–1360). Additional courses are chosen after consultation with the student’s faculty sponsor and graduate program director. Other requirements (qualifying examination, journal club, computer literacy) will be the same as those expected of Ph.D. students.
Qualifying Examination
Candidates for the Ph.D. degree are also required to pass both the written and oral components of a comprehensive Ph.D. qualifying examination administered by the program faculty near the end of the second year of study.
Candidacy
The student is eligible to enter doctoral candidacy after successful completion of the Qualifying Examination, the accumulation of at least 30 didactic credits including all required courses, and the recommendation of the program faculty.
Course Descriptions
| BIOC 1250 Biochemistry of Gene Expression | (4 credits) | Drs. Wu and M. Lee |
| (Previously offered as 246.4) | ||
| In vitro and in vivo aspects of DNA, RNA and
protein synthesis are covered in depth by instructors actively doing
research in each of these areas. Special emphasis is placed on methods and
techniques used to address key questions in the macromolecular processes of
DNA replication and repair, RNA transcription and processing, protein
synthesis, and post-translational modifications. Students are introduced to
principles and applications of molecular techniques and new discoveries in
the molecular biology of eukaryotes. Students are provided with a
comprehensive reading list. Lectures: 4 hrs/wk. Letter-graded.
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| PATH 1010 Morphological and Functional Basis of Pathobiology | (3 credits) | Dr. Moy (Summer) |
| (Previously offered as 401.3) | ||
| Objective-oriented, problem-solving review focused on basic
aspects of normal human anatomy, histology and physiology as they relate to
cellular and tissue responses occurring under pathobiological conditions.
Lectures and Conferences: 3 hrs/wk. Letter-graded.
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| PATH 1050 Conceptual Pathology | (1 credit) | Dr. Godfrey |
| (Previously offered as 405.1) | ||
| Intensive reading and discussion of primary papers in the
pathology literature with emphasis on basic concepts of pathogenesis and
disease processes to complement topics covered in PATH–1080. This course is
intended for Ph.D. students in other disciplines who are taking PATH–1080 as
an elective. Conferences: 1 hr/wk. Letter-graded. Open to Ph.D. students
only. Co-requisite: PATH–1080.
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| PATH 1080 Introduction to Pathology | (3 credits) | Dr. Moy and Staff |
| (Previously offered as 408.3) | ||
| An objective-oriented, problem-solving introduction to
general disease processes including: cellular alterations and inflammation,
genetic, immunological, nutritional and circulatory disorders; effects of
infection, chemical and physical agents, blood and vascular diseases,
neoplasia and aging. Topics to be covered also include analytic tools and
techniques, diagnostic methodology and criteria, and recognition and control
of environmental diseases. Lectures: 3 hrs/wk. Letter-graded. Prerequisite:
a course in general biology. Strongly recommended: PATH–1010 or equivalent.
Students may not receive credit for PATH–1080 if they have previously
received credit for PATH–1410.
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| PATH 1090 Systemic Pathology | (3 credits) | Dr. Moy and Staff |
| (Previously offered as 409.3) | ||
| Problem-oriented study of diseases specific for various
tissues (bladder, bone marrow, brain, kidney, liver, muscle, lung) and the
role of environmental contamination (arsenic, asbestos, lead, mercury,
allergens) in disease pathogenesis. Lectures: 3 hrs/wk. Letter-graded.
Prerequisite: PATH–1080 or PATH–1410. Students cannot receive credit for
PATH–1090 if they have previously received credit for PATH–1420.
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| PATH 1110 Fundamentals of Animal Research | (3 credits) | Dr. Levee |
| (Previously offered as 445.3) | ||
| A comprehensive course studying laboratory animals from
standpoints of care, management, handling, stress, spontaneous diseases,
routine clinical pathology procedures and techniques pertaining to
anesthesia, injections, breeding, euthanasia and necropsy. Lectures: 3
hrs/wk. Letter-graded.
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| PATH 1200 Introduction to Epidemiology | (3 credits) | Dr. Moy |
| (Previously offered as 420.3) | ||
| Basic principles, methodologies and sources of data
available to conduct research and monitoring activities in environmental and
public health. Epidemiologic research methods and study design issues
focusing on disease clusters, surveillance activity, characterization of
human exposures and risk and biomarkers will be explored. Lectures: 3
hrs/wk. Letter-graded.
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| PATH 1410 General Pathology | (6 credits) | Drs. Godfrey and Zachrau |
| (Previously offered as 441.6) | ||
| Cellular and molecular pathology of the basic mechanisms in
the structural and functional manifestation of disease are discussed in
detail. The concepts of biochemistry, physiology and cell biology are
utilized in developing a dynamic approach to the study of the abnormal cell
and its constituents. Lectures and Conferences: 6 hrs/wk. Letter-graded.
Open to Ph.D. students only.
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| PATH 1420 Systemic Pathology | (8 credits) | Drs. Godfrey and Zachrau |
| (Previously offered as 442.8) | ||
| An intensive study of disease by organ systems. The concepts
of general pathology are applied to the analysis of specific etiology and
pathogenesis. Lectures and conferences: 8 hrs/wk. Letter-graded.
Prerequisite PATH–1410. Open to Ph.D. students only.
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| PATH 2110 Introduction to Electron Microscopy | (2 credits) | Dr. Chander |
| (Previously offered as 455.2) | ||
| Theory and practice of transmission electron microscopy
applied to biological specimens. Laboratory exercises include specimen
preparation, operation of a research electron microscopy and associated
procedures. Lectures: 1 hr/wk. Laboratory: 2 hrs/wk. Letter-graded.
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| PATH 2210 Applied Environmental Science & Health | (3 credits) | Dr. Moy |
| (Previously offered as 421.3) | ||
| An overview and foundation in the diverse areas where the
environment and human health interact. Ecosystem principles will be
introduced as the context for discussion of environmental toxicants and
their hazards, water and air systems, community noise, accident
epidemiology, nutrition and public health, radiation, population dynamics,
solid and hazardous waste problems, vectors, microbes and disease,
environmental management and bioethics. Lectures: 3 hrs/wk. Letter-graded.
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| PATH 2220 Environmental Engineering and Health | (3 credits) | Dr. Moy |
| (Previously offered as 422.3) | ||
| The art and science of the protection of good health, the
promotion of sound ecological thinking, the prevention of disease and injury
through control of positive environmental factors, and the reduction of
potential physical, biological, chemical, and radiological hazards.
Environmental sanitation and engineering problems will be explored,
including communicable and non-infectious diseases, water and wastewater
treatment, solid waste, food protection, vector control and noise. Lectures:
3 hrs/wk. Letter-graded.
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| PATH 2230 Environmental Law, Policy and Management | (3 credits) | Dr. Moy |
| (Previously offered as 423.3) | ||
| Case studies and current legislative and regulatory
proposals will be examined to equip students with the knowledge needed to
interact with regulatory agencies and to impact the legislative process at
the federal, state and local levels. The final third of the course will
present an integrated approach to strategic management including total
quality management. Lectures: 3 hrs/wk. Letter-graded.
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| PATH 2310 Environmental Toxicology | (3 credits) | Dr. Moy |
| (Previously offered as 471.3) | ||
| Pharmacological basis of toxicology, toxicity testing in
animals (acute, chronic, reproductive and teratogemnicity, carcinogenicity),
alternative and in vitro toxicity testing, role of epidemiology and risk
assessment, regulatory and legal influences, applications in areas of
pesticides, pharmaceuticals, and medical devices. Lectures: 3 hrs/wk.
Letter-graded. Prerequisite: PATH–1080.
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| PATH 2320 Nutritional Toxicology | (3 credits) | Drs. Moy and Hoegler |
| (Previously offered as 473.3) | ||
| Examination of selected biochemical processes in a
physiological framework that explain the mechanisms of action of natural,
artificial and incidental toxins in food. Lectures: 3 hrs/wk. Letter graded.
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| PATH 2520 Air Pollution | (3 credits) | Dr. Moy |
| (Previously offered as 458.3) | ||
| An overview of atmospheric components and contaminants,
sources production, detection and impact on the environment and human
health. Lectures: 3 hrs/wk. Letter-graded.
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| PATH 2920 Health Physics in Research and Medicine | (2 credits) | Dr. Moy |
| (Previously offered as 952.2) | ||
| The first segment of the course, which is presented
concurrently with course PHYS–2920, introduces general concepts of radiation
physics, interaction of radiation with matter, radiation biology, dosimetry
and detection systems, and regulation of radioisotope uses. The second
segment explores practical aspects of health physics in the laboratory,
including simple applications, instrumentation, radiation waste disposal and
clinical application of radioisotopes. Students may not receive credit for
both PATH–2920 and PHYS–2920. Lectures: 2 hrs/wk. Letter-graded.
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| PATH 7010 Directed Readings In Experimental Pathology | (1-2 credits) | Dr. Moy |
| (Previously offered as 475.x.1-2) | ||
| This course is intended for advanced students who wish to
explore a particular area of experimental pathology in depth through
intensive study of the relevant scientific literature. Course content will
be designed to match the student’s interest with the expertise of the
Experimental Pathology faculty. Topics include: biochemistry; molecular
pathobiology; immunology; toxicology; cardiac, pulmonary, vascular neural or
renal pathology; environmental health sciences; environmental pathology;
biostatistics or epidemiology; or customized topics. Grades are based upon
examinations and written and oral reports by the student. May be taken for
credit more than once, with permission of the program director. Independent
study. Conferences: 1-2 hrs/wk. Letter-graded.
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| PATH 7610 Biological Safety Evaluation of Chemical Products | (2 credits) | Dr. Williams and Staff |
| (Previously offered as 461.2) | ||
| An introduction to all aspects of biological safety
evaluation of chemicals prior to clinical trials with emphasis on regulatory
considerations including: acute, subacute and chronic toxicity in small and
large laboratory animals; reproductive performance and teratology in rodents
and lagomorphs; in vitro and in vivo mutagenicity assays; special toxicities
and their mechanisms as they bear on regulatory decision-making; comparative
toxicokinetics. Lecture: 30 hrs. Pass/Fail Prerequisite: M.D., Ph.D., D.V.M.
or permission of instructor.
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| PATH 7620 Acute and Subchronic Toxicity | (4 credits) | Dr. Iatropoulos and Staff |
| (Previously offered as 462.4) | ||
| Design of single and multiple dose studies of up to 3 month
duration as part of pre-clinical safety assessment of chemical substances.
This course also includes laboratory hours. Lectures and Laboratory: 4
hrs/wk. Letter-graded. Prerequisite: M.D., Ph.D., D.V.M. or permission of
instructor.
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| PATH 7630 Chronic Toxicity and Carcinogenicity | (3 credits) | Dr. Iatropoulos and Staff |
| (Previously offered as 463.3) | ||
| Design of chronic studies for the purpose of studying
chronic effects of chemical substances including carcinogenicity. This
course also includes laboratory hours. Lecture and Laboratory: 3 hrs/wk.
Letter-graded. Prerequisite: M.D., Ph.D., D.V.M. or permission of
instructor.
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| PATH 7640 Mutagenic Effect of Chemical Products | (4 credits) | Dr. Iatropoulos and Staff |
| (Previously offered as 464.4) | ||
| Design of in vitro and in vivo assays for the purpose of
studying DNA effects, mutations, and elastogenicity elicited by chemical
substances. This course also includes laboratory hours. Lecture and
Laboratory: 4 hrs/wk. Letter-graded. Prerequisite: M.D., Ph.D., D.V.M. or
permission of instructor.
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| PATH 7660 Reproductive Performance and Teratology | (3 credits) | Dr. Iatropoulos and Staff |
| (Previously offered as 466.3) | ||
| Design of assays and studies to detect interference with
reproductive performance and teratogenic potential of chemical substances.
This course also includes laboratory hours. Lecture and Laboratory: 3
hrs/wk. Letter-graded. Prerequisite: M.D., Ph.D., D.V.M. or permission of
instructor.
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| PATH 7670 Mechanisms of Chemical Toxicity | (3 credits) | Dr. Iatropoulos and Staff |
| (Previously offered as 467.3) | ||
| Pathogenesis of chemically induced injury and limits of
adaptation of various tissues in both man and laboratory animals. This
course also includes laboratory hours. Lecture and Laboratory: 3 hrs/wk.
Letter-graded. Prerequisite: M.D., Ph.D., D.V.M. or permission of
instructor.
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| PATH 7680 Advanced Comparative Toxicokinetics | (3 credits) | Dr. Iatropoulos and Staff |
| (Previously offered as 468.3) | ||
| Adsorption, distribution, metabolism, excretion and overall
tissue response to toxic substances on the comparative level of man versus
laboratory animals. This course also includes laboratory hours. Lectures and
Laboratory: 3 hrs/wk. Letter-graded. Prerequisite: M.D., Ph.D., D.V.M. or
permission of the instructor.
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| PATH 7690 Diagnostic Problems and Methods in Drug-Induced Diseases | (3 credits) | Dr. Iatropoulos and Staff |
| (Previously offered as 469.3) | ||
| A detailed presentation of advanced topics in iatrogenic
illness. This course also includes laboratory hours. Lectures and
Laboratory: 3 hrs/wk. Letter-graded. Prerequisite: M.D., Ph.D., D.V.M. or
permission of instructor.
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| PATH 7710 Introduction to Toxicological Pathology | (3 credits) | Dr. Iatropoulos and Staff |
| (Previously offered as 413.3) | ||
| General principles of pathologic changes elicited by
chemical substances or physical devices/processes to which man or other
species are exposed by design or adventitiously. This course also includes
laboratory hours. Lectures and Laboratory: 3 hrs/wk. Letter-graded.
Prerequisite: M.D., Ph.D., D.V.M. or permission of instructor.
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| PATH 7720 Regulatory Experimental Pathology | (3 credits) | Dr. Iatropoulos and Staff |
| (Previously offered as 414.3) | ||
| Principles and considerations in experimental pathology when
safety assessment of chemical and physical products has to be tested as part
of their registration. This course also includes laboratory hours. Lecture
and Laboratory: 3 hrs/wk. Letter-graded. Prerequisite: M.D., Ph.D., D.V.M.
or permission of instructor, PATH–7710.
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| PATH 8010 Journal Club | (1 credits) | Dr. Godfrey |
| (Previously offered as 490.1) | ||
| Students present critical appraisals of published research
papers dealing with topics of current importance in experimental pathology.
Seminar: 1 hr/wk. Pass/Fail. Must be taken each semester by Ph.D. students.
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| PATH 8400 Internship in Environmental Sciences and Health | (2 credits) | Dr. Moy |
| (Previously offered as 425.2) | ||
| The internship is composed of several components including
workshops, an overview program in environmental health practice, a “shadow”
program at OSHA and an environmental corporate law practice followed by an
internship project carried out in an acceptable professional environmental
context. Internship: hours to be arranged. Pass/Fail.
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| PATH 8600 Techniques in Experimental Pathology | (1 credit) | Dr. Godfrey |
| (Previously offered as 460.1) | ||
| Through demonstrations and lectures, students learn the
theory and practice of laboratory techniques and instrumentation used in
experimental pathology, tissue and cell culture, chromatography and
electrophoresis, molecular genetics, electron microscopy, immunochemistry,
immunoassay, and spectrophotometry. Lectures: 1 hr/wk. Pass/Fail.
Prerequisite: Permission of instructor.
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| PATH 9110 Experimental Pathology Laboratory | (1 credit) | Dr. Godfrey |
| (Previously offered as 452.3) | ||
| Laboratory rotations in departmental laboratories for
first-year Ph.D. students. Guided involvement in active laboratory research
and directed readings in the relevant scientific literature. Research: hours
to be arranged. Pass/Fail. Open to Ph.D. students only. Must be taken and
completed twice.
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| PATH 9750 Master’s Literature Review | (1 credit) | Dr. Moy |
| (Previously offered as 497.1) | ||
| Library literature review paper summarizing the concepts and
research in the field of experimental pathology. Selection of topic and
preparation of paper is carried out under the guidance of a faculty advisor.
Independent study. Pass/Fail. Required for Master’s degree, Plan A.
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| PATH 9800 Master’s Thesis Research | (1-5 credits) | Dr. Moy |
| (Previously offered as 498.1-5) | ||
| Laboratory research project carried out under the guidance
of a faculty advisor and leading to submission and defense of a thesis.
Thesis research: hours to be arranged. Pass/Fail. May be taken multiple
times, but only five credits may be counted against Plan B Master’s degree
requirements.
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| PATH 9850 Master’s Thesis | (1 credit) | Dr. Moy |
| (Previously offered as 495.1) | ||
| Thesis describing background, rationale and investigation of
an original research project. Independent study. Pass/Fail. Required for
Master’s degree, Plan B.
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| PATH 9900 Doctoral Dissertation Research | Dr. Godfrey | |
| (Previously offered as 499.1-15) | ||
| Laboratory research project to be carried out under the
guidance of a faculty advisor leading to submission and defense of a
doctoral dissertation. Thesis research: hours to be arranged. Pass/Fail. May
be taken multiple times for a total of 15 credits. Open to Ph.D. students
only.
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Graduate Faculty and Research Interests
Praveen M. Chander, M.B.B.S.
Professor of Pathology
M.B.B.S. 1970, All-India Institute of Medical Sciences
Pathogenesis of renal and vascular damage in stroke-prone spontaneously hypertensive rats; pathogenesis of HIV-associated nephropathy.
Fung-Lung Chung, Ph.D.
Research Associate Professor of Pathology; Division Chief, American
Health Foundation
Ph..D. 1978, University of Utah
Enals, nitrosamines and isothiocyanates in carcinogenesis; chemoprevention of cancer by organoselenium, tea and tobacco in carcinogenesis.
Wei Dai,
Ph.D.
Professor of Medicine; Professor of Biochemistry and Molecular Biology
B.S. 1982, Nanjing Agricultural University; M.S. 1986, Ph.D. 1988, Purdue University
Research/Interests - Cell cycle regulation.
Zbigniew Darzynkiewicz, M.D., Ph.D.
Professor of Medicine; Professor of Pathology; Professor of Microbiology
and Immunology; Director, Cancer Research Institute
M.D. 1960, Ph.D. 1966, Medical School of Warsaw (Poland)
Development of new methods of cell analysis applicable to flow cytometry; analysis of cell cycle specificity of anti-tumor drugs.
Karam El-Bayoumy, Ph.D.
Research Associate Professor of Pathology; Division Chief, American
Health Foundation
Ph.D. 1978, New York University
Identification and mechanisms of action of environmental carcinogens.
Henry P. Godfrey, M.D., Ph.D
Professor of Pathology; Graduate Program Director, (Ph.D. program)
M.D. 1965, Harvard Medical School; Ph.D.1980, University of Birmingham (England)
Biochemical mechanisms of delayed hypersensitivity; lymphokines, cytokines and microbial antigens in chronic inflammation and infectious disease.
Michael Iatropoulos, M.D.
Research Professor of Pathology
M.D 1964, Ph.D. 1965, University of Tuebingen (Germany)
Comparative mechanisms of toxicity and carcinogenesis.
Alan M. Jeffrey, Ph.D.
Research Professor of Pathology
Ph.D. 1970, University College of North Wales, Bangor (U.K.)
Toxicology and chronic carcinogenesis.
Meena Jhanwar-Uniyal, Ph.D.
Clinical Associate Professor of Pathology; Research Scientist American
Health Foundation
Ph.D. 1979, Academy of Science (Moscow, Russia)
Signal transduction, BRCAI gene p53 cancer, central nervous system in obesity.
Ashok Kumar, Ph.D.
Professor of Pathology
M.Sc. 1960, Agra University (India); Ph.D. 1963 Allahabad University (India)
Role and molecular analysis of renin-angiotensin system in hypertension and atherosclerosis.
Jane H.-C. Lin, Ph.D.
Research Assistant Professor of Pathology
Ph.D. 1987, University of Illinois
Molecular mechanisms governing endothelial cell dysfunctions during atherogenesis.
Myron R. Melamed, M.D.
Professor and Chairman of Pathology
M.D. 1950, University of Cincinnati
Flow and static cytometry of human cancer cells in conjunction with cytochemical, immunochemical, and in situ nucleic acid reactions for diagnostic and prognostic purposes.
Fred H. Moy, Ph.D.
Associate Professor of Clinical Pathology; Graduate Program Director
(M.S. Programs)
Ph.D. 1986, Sussex (UK), MBA 1991, University of California at Los Angeles
Biostatistics and epidemiology, methodology and applications in environmetrics, lead exposure, risk assessment, reproductive epidemiology, biomarkers and molecular epidemiology, evaluation and assessment in health sciences.
John P. Richie, Ph.D.
Research Associate Professor of Pathology; Scientist, American Health
Foundation
Ph.D. 1986, University of Louisville
Biochemical mechanisms of disease susceptibility in relation to aging and nutrition.
Frank Traganos, Ph.D.
Professor of Medicine; Professor of Pathology; Professor of Microbiology
and Immunology; Associate Director, Cancer Research Institute
Ph.D. 1979, Cornell University
Cell biology-study of mechanisms involved in control of cell cycle progression (check points) and cell death (apoptosis) in model systems (cell cultures) and clinical material.
John H. Weisburger, Ph.D., M.D. (hon.)
Research Professor of Pathology; Director Emeritus, American Health
Foundation
Ph.D. 1949, University of Cincinnati; M.D. 1980, Umea (Sweden)
Mechanisms of toxicity, carcinogenicity; mechanisms and role of promoters in major human cancers; role of nutrition in human carcinogenesis; rational means of prevention of cancer, coronary heart disease, and stroke.
Gary M. Williams, M.D.
Professor of Pathology
M.D. 1967, University of Pittsburgh School of Medicine.
Mechanisms of carcinogenesis; metabolic and genetic effects of chemical carcinogens.
Reinhard E. Zachrau, M.D.
Professor of Pathology
M.D. 1964, University of Heidelberg (Germany).
Spontaneous and induced tumor-specific cell-mediated immunity in human breast cancer and its role in development of systemic metastasis and second primary cancers of breast and non-breast origin.