Prominent Yale Scientist Will Address the 28th Annual Graduate Student Research Forum
Annual Graduate Student Research Forum, sponsored by the Graduate Student Association, will take place on Tuesday, March 15. The daylong event will feature poster and oral presentations by graduate students and a keynote address by Patrick Sung, Ph.D.,
professor of molecular biophysics and biochemistry and of therapeutic radiology at Yale University School of Medicine. Dr. Sung will present "The Role of the BRCA2-DSS1 Complex in DNA Break Repair."
Monica K. Cheng, Ph.D. '03, deputy head of business development and licensing, cardiometabolic diseases at Boehringer Ingelheim Pharmaceuticals, Inc., will serve as the alumna moderator of the day's events.
Dr. Sung's research focus es on mechanisms associated with homology-directed repair of DNA double-strand breaks in Saccharomyces cerevisiae and in mammalian cells. The double - stranded DNA repair pathway uses a process of homologous recombination to promote error-free repair. Central to this process is the group of RAD52 genes that are essential for DNA damage repair induced by ionizing radiation. In mammals, the efficiency of recombinational DNA repair is modulated by tumor suppressor proteins, BRCA1 and BRCA2. Dr. Sung has identified that these nuclear proteins have a critical role in response to DNA damage and exhibit a binding domain that interacts with human RAD proteins. His studies provide a rationale of how losses of BRCA function may compromise RAD-mediated DNA repair systems ultimately destabilizing the genome and contributing to cancerous growth.
Dr. Sung served as chairman of the Department of Molecular Biophysics and Biochemistry at Yale and chaired the Cancer Etiology Study Section at the National Institutes of Health. He received his B.S. degree from the University of Liverpool and his Ph.D. degree from Oxford University. He serves on the editorial boards of Genes and Development and DNA Repair and is an associate editor of the Journal of Biological Chemistry.