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Course
Descriptions
PATH 1010 Morphological and
Functional Basis of Pathobiology
(3 credits) Dr.
Moy (Summer)
Objective-oriented, problem-solving
review focused on basic aspects of normal human anatomy, histology
and physiology as they relate to cellular and tissue responses
occurring under pathobiological conditions. Lectures and
Conferences: 3 hrs/wk. Letter-graded.
PATH 1050 Conceptual Pathology
(1 credit) Dr. Godfrey
Intensive reading and discussion of
primary papers in the pathology literature with emphasis on basic
concepts of pathogenesis and disease processes to complement topics
covered in PATH–1080. This course is intended for PhD. students in
other disciplines who are taking PATH–1080 as an elective.
Conferences: 1 hr/wk. Letter-graded. Open to Ph.D. students
only. Co-requisite: PATH–1080.
PATH 1080 Introduction to
Pathology
(3 credits) Dr. Moy and
staff
An objective-oriented,
problem-solving introduction to general disease processes including:
cellular alterations and inflammation, genetic, immunological,
nutritional and circulatory disorders; effects of infection,
chemical and physical agents, blood and vascular diseases, neoplasia
and aging. Topics to be covered also include analytic tools and
techniques, diagnostic methodology and criteria, and recognition and
control of environmental diseases. Lectures: 3 hrs/wk.
Letter-graded. Prerequisite: a course in general biology.
PATH-1010 or its equivalent is recommended. Students may not
receive credit for PATH–1080 if they have previously received credit
for PATH–1410.
PATH 1090 Systemic Pathology
(3 credits) Dr. Moy
and staff
Problem-oriented study of diseases
specific for various tissues (bladder, bone marrow, brain, kidney,
liver, muscle, lung) and the role of environmental contamination
(arsenic, asbestos, lead, mercury, allergens) in disease
pathogenesis. Lectures: 3 hrs/wk. Letter-graded. Prerequisite:
PATH–1080 or PATH–1410. Students cannot receive credit for
PATH–1090 if they have previously received credit for PATH–1420.
PATH 1110 Fundamentals of
Animal Research
(3 credits) Dr. Levee
A comprehensive course studying
laboratory animals from standpoints of care, management, handling,
stress, spontaneous diseases, routine clinical pathology procedures
and techniques pertaining to anesthesia, injections, breeding,
euthanasia and necropsy. Lectures: 3 hrs/wk. Letter-graded.
PATH 1200 Introduction to
Epidemiology
(3 credits) Dr. Moy
Basic principles, methodologies and
sources of data available to conduct research and monitoring
activities in environmental and public health. Epidemiologic
research methods and study design issues focusing on disease
clusters, surveillance activity, characterization of human exposures
and risk and biomarkers will be explored. Lectures: 3 hrs/wk.
Letter-graded.
PATH 1410 General Pathology
(6 credits) Drs. Godfrey and Zachrau
Cellular and molecular pathology of
the basic mechanisms in the structural and functional manifestation
of disease are discussed in detail. The concepts of biochemistry,
physiology and cell biology are utilized in developing a dynamic
approach to the study of the abnormal cell and its constituents.
Lectures and Conferences: 6 hrs/wk. Letter-graded. Open to
Ph.D. students only.
PATH 1420 Systemic Pathology
(8 credits) Drs. Godfrey and
Zachrau
An intensive study of disease by
organ systems. The concepts of general pathology are applied to the
analysis of specific etiology and pathogenesis. Lectures and
conferences: 8 hrs/wk. Letter-graded. Prerequisite PATH–1410.
Open to Ph.D. students only.
PATH 2210 Applied
Environmental Science & Health
(3 credits) Dr. Moy
An overview and foundation in the
diverse areas where the environment and human health interact.
Ecosystem principles will be introduced as the context for
discussion of environmental toxicants and their hazards, water and
air systems, community noise, accident epidemiology, nutrition and
public health, radiation, population dynamics, solid and hazardous
waste problems, vectors, microbes and disease, environmental
management and bioethics. Lectures: 3 hrs/wk. Letter-graded.
PATH 2220 Environmental
Engineering and Health
(3
credits) Dr. Moy
The art and science of the
protection of good health, the promotion of sound ecological
thinking, the prevention of disease and injury through control of
positive environmental factors, and the reduction of potential
physical, biological, chemical, and radiological hazards.
Environmental sanitation and engineering problems will be explored,
including communicable and non-infectious diseases, water and
wastewater treatment, solid waste, food protection, vector control
and noise. Lectures: 3 hrs/wk. Letter-graded.
PATH 2230 Environmental Law,
Policy and Management
(3
credits) Dr. Moy
Case studies and current legislative
and regulatory proposals will be examined to equip students with the
knowledge needed to interact with regulatory agencies and to impact
the legislative process at the federal, state and local levels. The
final third of the course will present an integrated approach to
strategic management including total quality management. Lectures:
3 hrs/wk. Letter-graded.
PATH 2310 Environmental
Toxicology
(3 credits)
Dr. Moy
Pharmacological basis of toxicology,
toxicity testing in animals (acute, chronic, reproductive and
teratogenicity, carcinogenicity), alternative and in vitro toxicity
testing, role of epidemiology and risk assessment, regulatory and
legal influences, applications in areas of pesticides,
pharmaceuticals, and medical devices. Lectures: 3 hrs/wk.
Letter-graded. Prerequisite: PATH–1080 or PATH-1410.
PATH 2320 Nutritional
Toxicology
(3 credits)
Drs. Moy
Examination of selected biochemical
processes in a physiological framework that explain the mechanisms
of action of natural, artificial and incidental toxins in food.
Lectures: 3 hrs/wk. Letter graded.
PATH 2520 Air Pollution
(3 credits) Dr. Moy
An overview of atmospheric
components and contaminants, sources production, detection and
impact on the environment and human health. Lectures: 3 hrs/wk.
Letter-graded.
PATH 2920 Health Physics in
Research and Medicine
(2 credits) Dr. Moy
The first segment of the course,
which is presented concurrently with course PHYS–2920, introduces
general concepts of radiation physics, interaction of radiation with
matter, radiation biology, dosimetry and detection systems, and
regulation of radioisotope uses. The second segment explores
practical aspects of health physics in the laboratory, including
simple applications, instrumentation, radiation waste disposal and
clinical application of radioisotopes. Students may not receive
credit for both PATH–2920 and PHYS–2920. Lectures: 2 hrs/wk.
Letter-graded.
PATH 7010 Directed Readings In
Experimental Pathology
(1-2 credits) Dr. Moy
This course is intended for advanced students who wish to explore a
particular area of experimental pathology in depth through intensive
study of the relevant scientific literature. Course content will be
designed to match the student’s interest with the expertise of the
Experimental Pathology faculty. Topics include: biochemistry;
molecular pathobiology; immunology; toxicology; cardiac, pulmonary,
vascular neural or renal pathology; environmental health sciences;
environmental pathology; biostatistics or epidemiology; or
customized topics. Grades are based upon examinations and written
and oral reports by the student. May be taken for credit more than
once, with permission of the program director. Independent study.
Conferences: 1-2 hrs/wk. Letter-graded.
PATH 7610 Biological Safety
Evaluation of Chemical Products
(2
credits) Dr. Williams
An introduction to all aspects of
biological safety evaluation of chemicals prior to clinical trials
with emphasis on regulatory considerations including: acute,
subacute and chronic toxicity in small and large laboratory animals;
reproductive performance and teratology in rodents and lagomorphs;
in vitro and in vivo mutagenicity assays; special toxicities and
their mechanisms as they bear on regulatory decision-making;
comparative toxicokinetics. Lecture: 30 hrs. Pass/Fail
Prerequisite: M.D., Ph.D., D.V.M. or permission of instructor.
N.B. Courses PATH-7620 through
PATH-7720 are available only to students matriculated in the Plan E
Master’s track.
PATH 7620 Acute and Subchronic
Toxicity
(4 credits) Dr. Iatropoulos
Design of single and multiple dose
studies of up to 3 month duration as part of pre-clinical safety
assessment of chemical substances. This course also includes
laboratory hours. Lectures and Laboratory: 4 hrs/wk.
Letter-graded. Prerequisite: M.D., Ph.D., D.V.M. or permission of
instructor.
PATH 7630 Chronic Toxicity and
Carcinogenicity
(3 credits) Dr. Iatropoulos
Design of chronic studies for the
purpose of studying chronic effects of chemical substances including
carcinogenicity. This course also includes laboratory hours.
Lecture and Laboratory: 3 hrs/wk. Letter-graded. Prerequisite:
M.D., Ph.D., D.V.M. or permission of instructor.
PATH 7640 Mutagenic Effect of
Chemical Products
(4 credits) Dr. Iatropoulos
Design of in vitro and in
vivo assays for the purpose of studying DNA effects, mutations,
and elastogenicity elicited by chemical substances. This course
also includes laboratory hours. Lecture and Laboratory: 4 hrs/wk.
Letter-graded. Prerequisite: M.D., Ph.D., D.V.M. or permission of
instructor.
PATH 7660 Reproductive
Performance and Teratology
(3 credits) Dr. Iatropoulos
Design of assays and studies to
detect interference with reproductive performance and teratogenic
potential of chemical substances. This course also includes
laboratory hours. Lecture and Laboratory: 3 hrs/wk. Letter-graded.
Prerequisite: M.D., Ph.D., D.V.M. or permission of instructor.
PATH 7670 Mechanisms of
Chemical Toxicity
(3 credits) Dr. Iatropoulos
Pathogenesis of chemically induced
injury and limits of adaptation of various tissues in both man and
laboratory animals. This course also includes laboratory hours.
Lecture and Laboratory: 3 hrs/wk. Letter-graded. Prerequisite:
M.D., Ph.D., D.V.M. or permission of instructor.
PATH 7680 Advanced Comparative
Toxicokinetics
(3
credits) Dr. Iatropoulos
Adsorption, distribution,
metabolism, excretion and overall tissue response to toxic
substances on the comparative level of man versus laboratory
animals. This course also includes laboratory hours. Lectures and
Laboratory: 3 hrs/wk. Letter-graded. Prerequisite: M.D., Ph.D.,
D.V.M. or permission of the instructor.
PATH 7690 Diagnostic Problems
and Methods in Drug-Induced Diseases
(3 credits) Dr. Iatropoulos
A detailed presentation of advanced
topics in iatrogenic illness. This course also includes laboratory
hours. Lectures and Laboratory: 3 hrs/wk. Letter-graded.
Prerequisite: M.D., Ph.D., D.V.M. or permission of instructor.
PATH 7710 Introduction to
Toxicological Pathology
(3 credits) Dr. Iatropoulos
General principles of pathologic
changes elicited by chemical substances or physical
devices/processes to which man or other species are exposed by
design or adventitiously. This course also includes laboratory
hours. Lectures and Laboratory: 3 hrs/wk. Letter-graded.
Prerequisite: M.D., Ph.D., D.V.M. or permission of instructor.
PATH 7720 Regulatory
Experimental Pathology
(3 credits) Dr. Iatropoulos
Principles and considerations in
experimental pathology when safety assessment of chemical and
physical products has to be tested as part of their registration.
This course also includes laboratory hours. Lecture and Laboratory:
3 hrs/wk. Letter-graded. Prerequisite: M.D., Ph.D., D.V.M. or
permission of instructor, PATH–7710.
PATH 8010 Journal Club
(1
credit) Dr. Godfrey
Students present critical appraisals
of published research papers dealing with topics of current
importance in experimental pathology. Seminar: 1 hr/wk.
Pass/Fail. Must be taken each semester by Ph.D. students.
PATH 8400 Internship in
Environmental Sciences and Health
(2
credits) Dr. Moy
The internship is composed of
several components including workshops, an overview program in
environmental health practice, a “shadow” program at OSHA and an
environmental corporate law practice followed by an internship
project carried out in an acceptable professional environmental
context. Internship: hours to be arranged. Pass/Fail.
PATH 8600 Techniques in
Experimental Pathology
(1
credit) Dr. Godfrey
Through demonstrations and lectures,
students learn the theory and practice of laboratory techniques and
instrumentation used in experimental pathology, tissue and cell
culture, chromatography and electrophoresis, molecular genetics,
electron microscopy, immunochemistry, immunoassay, and
spectrophotometry. Lectures: 1 hr/wk. Pass/Fail. Prerequisite:
Permission of instructor.
PATH 9110 Research Rotation in
Experimental Pathology
(1 credit) Dr. Godfrey
Laboratory rotations in departmental
laboratories for first-year Ph.D. students. Guided involvement in
active laboratory research and directed readings in the relevant
scientific literature. Research: hours to be arranged. Graded on a
Satisfactory / Unsatisfactory basis. Open to Ph.D. students
only. Must be taken and completed twice.
PATH 9200 Research Techniques
in Experimental Pathology
(1 credit) Dr. Godfrey
Research training undertaken by
Ph.D. students after choosing a dissertation sponsor, but before
achieving candidacy. Research. Graded on a Satisfactory /
Unsatisfactory basis. May be taken multiple times. Open to
Ph.D. students only.
PATH 9700 Master’s Independent
Study
(1 credit) Dr. Moy
Candidates for the Master of Science
degree (Plan A, C, D and E) in the Experimental Pathology program
may use this course to receive credit for reading and analyzing the
scientific literature they will use in writing their mandatory
Master’s Literature Review (PATH-9750). Students enrolled in
PATH-9700 should provide their faculty advisor with frequent and
regular updates on their progress. Independent study. Graded on a
Satisfactory / Unsatisfactory basis. Open to Master’s students
only.
PATH 9750 Master’s Literature
Review
(1 credit) Dr.
Moy
This course is entered on the
student’s transcript when the Master’s Literature Review is approved
by the faculty review committee and submitted in final form to the
Graduate School. Required for Master’s degree under Plans A, C, D
and E. Independent study. Pass only.
PATH 9800 Master’s Thesis
Research
(1-5 credits) Dr.
Moy
Candidates for the Master of Science
degree (Plan B) in Experimental Pathology may elect to conduct a
research project under the supervision of a faculty member.
Submission of an acceptable final report summarizing results is
required (PATH–9850). Thesis Research. Pass/Fail. May be taken
multiple times, for one to five credits per term, but only five
credits can be applied towards program requirements. Open to
Master’s students only.
PATH 9850 Master’s Thesis
(0
credits) Dr. Moy
This course is entered on the
student’s transcript when the Master’s Thesis is approved by the
faculty review committee and submitted in final form to the Graduate
School. Required for “Plan B” Master’s degree. Independent study.
Pass only.
PATH 9900 Doctoral
Dissertation Research
(1 credit) Dr. Godfrey and staff
Laboratory research project to be
carried out under the guidance of a faculty advisor leading to
submission and defense of a doctoral dissertation. Thesis research:
hours to be arranged. Graded on a Satisfactory / Unsatisfactory
basis. May be taken multiple times. Open to Ph.D. students
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