Molecular Neurobiology

Molecular Neurobiology (BMS 3010)
Faculty	Date		Topic	Reading	Instructor
Dr. Leonard 594-4107 (Dept. of Physiology, BSB 626)	23-Jan	The course, basic bioelectricity, passive properties and action potential 1		K,S&J p125-158; Hille ch1&2*; Hodgkin & Katz, '49	Dr. Ross
Dr. Ross 594-4100 (Dept. of Physiology, BSB 607)	30-Jan	Action potential 2 and intro to ion channels		K,S&J p125-158; Hille ch1&2*; Hodgkin & Huxley '52c	Dr. Ross
Dr. Sabban 594-4068 (Dept. of Biochemistry, BSB 113)	06-Feb	Voltage-gated ion channels		K,S&J Ch6, 158-169; Hille ch3; Aldrich et al. 82	Dr. Leonard
	13-Feb	Channel diversity and intrinsic properties of neurons			Dr. Leonard
Text: Principles of Neural Science Kandel, Schwartz & Jessel 2000, 4th Edition Mcgraw-Hill.	20-Feb	Excitation release coupling and short-term synaptic plasticity			Dr. Ross
	27-Feb	Neurosecretion and the molecular basis for transmitter release			Dr. Sabban
• Additional reading from Ion Channels of Excitable Membranes 2001, 3rd Edition Hille
	06-Mar	Biosynthesis of transmitters and their molecular regulation			Dr. Sabban
• Journal articles to be assigned	13-Mar	Fast synaptic potentials+Ligand gated Ion channels			Dr. Leonard
	20-Mar	EXAM

Time and place: All classes meet Wed. afternoons at 4-6pm in room BSB 609	27-Mar	*No Class*
	03-Apr	Neuromodulation and dendritic integration			Dr. Ross
	10-Apr	Intracellular signaling pathways from receptors to effectors (short-term signals)			Dr. Sabban
Grades: The grade will be determined by the equal weighting of an in-class Exam, a 30 min. oral presentation and a paper. The exam will be held on 3/20/02 and the paper is due 5/8/02. The paper and presentation must be written on a topic chosen by consultation with an instructor.
	17-Apr	Intracellular pathways from receptors to effectors (long-term signals)			Dr. Sabban
	24-Apr	Plasiticity in the nervous system- LTP, Growth factors			Drs. Leonard / Sabban
	01-May	Student Presentations			Faculty
	08-May	Student Presentations (NB: Papers Due)			Faculty
Note:	* = Optional
Upcoming Reading:	Hodgkin AL and Katz B (1949) The effect of sodium ions on the electrical activity of the giant axon of the squid. J Physiol (Lond) 108: 37-77.
	Hodgkin A and Huxley A (1952) A quantitative description of membrane current and its application to conduction and excitation in nerve. J Physiol (Lond) 117: 500-544.
	Aldrich RW, Corey DP and Stevens CF (1983) A reinterpretation of mammalian sodium channel gating based on single channel recording. Nature 306(5942): 436-441.