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Dynamics of intracellular sodium ions are revealed
by high speed imaging of cerebellar Purkinje cell injected with a Na-indicator
dye. See references from Drs. Ross and Lasser-Ross lab.
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Blood vessel diameter is controlled by numerous mechanisms and is studied both in vivo (image to the left) and in vitro. See references from Dr. Koller's lab. |
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Considerable evidence indicates that a select group of brainstem cholinergic neurons (Green) play a pivotal role in controlling the behavioral states of Waking and Rapid Eye Movement sleep. Research in Dr. Leonard's lab is aimed at identifying the chemical signals that modulate the activity of these cells. Reconstructing the shapes of these cells after the intracellular injection of a marker revealed that they have recurrent axon collaterals (Red) This suggests these cells can modulate their own activity. See Surkis et al, 1996. |
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Direct application of the neurotransmitter Serotonin (yellow traces) and Carbachol, an Acetylecholine analogue (Red traces) strongly inhibits identified brainstem cholinergic neurons. AMong other things these findings suggest that recurrent axon collaterals control the activity of this population of neurons by feedback inhibition. See Leonard and Llinas, 1994 |
