Jan Geliebter, Ph.D.
Professor - Department of Microbiology and Immunology and Otolaryngology
Resident Research Coordinator - Department of Otolaryngology
Course Director - Medical Microbiology
Regional Vice President - Executive Committee of Faculty Senate
Member - Executive Committee of Education and Curriculum
Dept. of Microbiology & Immunology
Basic Sciences Building Room 311
New York Medical College
Valhalla, NY 10595
The focus of our research is the molecular pathogenesis of papillary thyroid cancer (PTC). We are using RNASeq to interrogate the landscape of gene expression alteration in PTC in clinical samples. By comparing PTC and samples of normal tissues from the same patients we have gained insight into the molecular changes driving PTC, as well as potential therapeutic targets. As men have a lower incidence of PTC than women, we are concentrating on the role of androgens in the etiology and progression of PTC. Our results indicate that androgens exert an anti-proliferative effect and result in a G1-S block in the cancer cell cycle.
Graduate Degree Institution:
State University of New York Health Science Center at Brooklyn
Hebrew University of Jerusalem, Israel, BSc, Biology
Zeoli, C.D., Maitland, M., Rose, H., Bloom, B.R., Mittleman, A. and Geliebter, J. 2001. Expression of Prostate Specific Molecules in Bacille Calmette-Guerin (BCG): An Immunotherapeutic Approach to Prostate Cancer. Prostate J. 3:92-97.
Geliebter, J. Chemokines: small, but powerful regulators of the immune system – potential anti-tumor targets and reagents. 2002. Cancer Investigation. 20:857-858.
Reyes, N., Iatropoulos, M., Mittelman, A. and Geliebter, J. Microarray analysis of diet-induced alterations in gene expression in the ACI rat prostate. 2002. European J. Cancer Prev. 11: S37-S42.
Geliebter, J., Mittelman, A.and Tiwari, R.K. 2003. Molecular Phenotyping of the Immune System by Microarray Analysis. Cancer Investigation. 21, 289-299.
Kanduc D, Capuano F, Capurso SA, Geliebter J, Guercia D, Lucchese A, Mittelman A, Simone SM, Sinha AA, Tiwari R, Farber E.. 2003. Cancer prevention and therapy: strategies and problems. J Exp Ther Oncol. 3:108-14.
Reyes, N., Reyes, I. Tiwari, R.K., and Geliebter, J. 2004. Effect of linoleic acid on proliferation and gene expression in the breast cancer cell line T47D. 2004. Cancer Letters. 209:25-35.
Liu, X., Tiwari, R.K., Geliebter, J., Wu, JM and Godfrey, H.P. 2004. Interaction of a Mycobacterium tuberculosis repetitive DNA sequence with eukaryotic proteins. Biochem Biophys. Res. Comm. 320:966-972.
Tiwari, R., Geliebter, J., Lucchesea, A., Mittelman, A. and Kanduc, D. 2004. Computational peptide dissection of Melan-A/MART-1 oncoprotein antigenicity. Peptides 25:1865-71.
Reyes, I., Reyes, N., Iatropoulos, M., Mittelman, A. and J. Geliebter. 2005 Aging-associated changes in gene expression in the ACI rat prostate: implications for carcinogenesis. The Prostate. 63:169-86.
Tadi, K. Chang, C., Ashok, B.T., Chen, Y., Moscatello, A., Schaefer, S.D., Schantz, S.P., Policastro, A.J., Geliebter, J., Tiwari, R.K. 2005. 3,3’Diindolylmethane, a cruciferous vegetable derived synthetic anti-proliferative compound in thyroid disease. Biochem Biophys. Res. Comm. 337(3):1019-25.
Kanduc, D., Geliebter, J., Lucchese, J., Mazzanti, R., Mittelman, A., Polimeno, L., Ponzetto, A., Santacroce, R., Simone, S., Sinigaglia, E., Sinha, A., Tessitore, L., Tiwari, R.K., Farber, E. 2005. Gene therapy in cancer: the missing point. Journal of Experimental Therapeutics and Oncology 5: 151-158
Suriano R, Lin Y, Ashok BT, Schaefer SD, Schantz SP, Geliebter J, Tiwari RK. 2006. Pilot study using SELDI-TOF-MS based proteomic profile for the identification of diagnostic biomarkers of thyroid proliferative diseases J Proteome Res. 5: 856-61
Reyes, N. Reyes, I. Tiwari, R. and Geliebter, J. 2007. Microarray analysis reveals metastasis associated genes in prostate cancer cell lines. Biomedica, 27:190-203.
Rajoria, Shilpi, Suriano, Robert, Shanmugan, Aulkumaran, Wilson, Yushan, Schantz, Stimson, Geliebter, Jan and Tiwari, Raj. 2010 Metastatic phenotype is regulated by estrogen in thyroid cancer. Thyroid. 20(1):33-41.
Hofkamp, L., Bradley, S., Geliebter, J. and Timms, B. 2010. Atypical fetal prostate development is associated with ipsilateral hypoplasia of the Wolffian ducts in the ACI rat. The Anatomical Record. 293:747-53.
Theodore S. Nowicki, Nicolas T. Kummer, Codrin Iacob, Nina Suslina, Augustine Moscatello, Steven Schaefer, Stimson Schantz, Edward Shin, Raj K. Tiwari, and Jan Geliebter. 2010. uPA and uPAR Promote Invasion and Metastasis in Papillary Thyroid Carcinoma Cells. Laryngoscope. 120:1383-90.
Shilpi Rrajoria, Robert Suriano, Arulkumaran Shanmugam, Andrea George, Stimson Schantz, Jan Geliebter, and Raj Tiwari. 2011 3,3'-diindolylmethane inhibits estrogen mediated metastatic propensity of thyroid cancer. Thyroid. 20:33-41.
Theodore S. Nowicki, Hong Zhao, Zbigniew Darzynkiewicz,, Stimson Schantz, Edward Shin, Raj K. Tiwari, and Jan Geliebter. 2011 Down-regulation of uPAR inhibits migration, invasion, proliferation, and FAK/PI3K/Akt signaling in papillary thyroid carcinoma cells. Cell Cycle. 10:100–107.
Rajoria S, Suriano R, Wilson YL, Schantz SP, Moscatello A, Geliebter J, Tiwari RK. 2011. 3,3’-diindolylmethane inhibits migration and invasion of human cancer cells through combined suppression of ERK and AKT pathways. Oncology Reports. 25: 491-497.
Rajoria S, Suriano R, Wilson YL, Schantz SP, George A, Geliebter J, Schantz SP and Tiwari RK. 2011. Estradiol Mediated Tumor Neovascularization. Oncology Letters. In press.
Rajoria S, Suriano R, Wilson YL, Schantz SP, Moscatello A, Geliebter J, Tiwari RK. 2011. Metastatic modulators MMP2/MMP9 are targets of the antiestrogen DIM in thyroid cancer: Implication for cancer prevention and diagnosis. PLOS ONE. 6:1-11.
E.Ashlie Darr, Anand D. Patel, Zbigniew Komorowski, Steven McCormick Stimson P. Schantz, Raj Tiwari and Jan Geliebter. Reduced Cx43 Expression Differentiates Follicular Thyroid Carcinoma from Follicular Adenoma. Otolaryngology -- Head and Neck Surgery. In press