Diseases and maladies result from complex interactions between an individual’s genetic make-up and the environmental agents and microbes that he or she is exposed to. In our daily environment mold, air pollution, cleaning solutions and pesticides and dust mites can pose a recurrent health challenge. Heritable genetic factors cause some people to respond distinctly when exposed to the same environmental agent. As a result, some individuals are unlikely to develop a disease through an environmental insult, while others are much more vulnerable. Recently scientists have gained insights into the molecular mechanisms underlying these individually unique responses connection between genetics and environmental factors, and how that connection may influence human disease. This course explores these emerging determinants of environmental disease.