This course provides the scientific rationale for predicting human response to exercise. The course focuses on the acute and chronic adaptations to exercise in the musculoskeletal, cardiopulmonary, and neuromuscular systems. Also covered are healing mechanisms in various tissues, and the response of injured tissue to biomechanical forces. In addition, exercise intervention in special populations such as pediatrics, geriatrics, and the pregnant female are discussed. Finally, the course introduces selected assessment and therapeutic exercise theories and techniques.