Joseph D. Etlinger, Ph.D.
Chair and Professor
Department of Cell Biology and Anatomy
With Alfred L. Goldberg, I discovered non-lysosomal ATP-dependent proteolytic activity, credited by awardees of the 2004 Nobel prize in chemistry, as the seminal observation revealing the proteasome/ubiquitin system. In subsequent studies, with my students and colleagues, we identified novel factors involved in the regulation of this pathway including a ubiquitin ligase critical to pulmonary arterial hypertension. We proposed how myofibrils turnover during muscle growth and atrophy and the roles of calcium, ATP, and beta -adrenergic receptors in these conditions. Finally, we have identified modalities to improve recovery from spinal cord injury including beta agonists, x-irradiation, and inhibitors of glucose toxicity.
Education:
Ph.D. in Biophysics, University of Chicago
B.S. in Physics, Rensselaer Polytechnic Institute
Postdoctoral Fellowship in Physiology and Biochemistry, Harvard Medical School
Courses Taught: Medical Cell Biology and Anatomy, Graduate Histology and Graduate Cell Biology, Dental Histology, Cell Biology Topics and Journal Club
Honors and Awards:
Established Investigator of the American Heart Association
Irma T. Hirschl Award, Principal Investigator on grants from NIH, NASA and MDA
Selected Bibliography:
Joseph D Etlinger - Google Scholar
