In my laboratory, over the past 10 years, research has primarily been focused on two areas. The first has been to characterize the relevance of the stringent response and the (p)ppGpp alarmon to the physiology and metabolism of Borrelia burgdorferi during its passage and persistence between ticks and mice in the enzootic cycle. We are particularly interested on the potential of the stringent response to mediate resistance of this spirochete to host immune responses and other antimicrobial activities. The second area of our research has dealt with the impact of antimicrobial use in aquaculture on antimicrobial resistance in the marine environment. This work has involved characterization of antimicrobial resistance genes and mobile genetic elements of the marine resistome as a first step towards elucidating the mechanisms linking the aquatic resistome to those of human and terrestrial animal pathogens.
Dept. of Microbiology & Immunology
Basic Sciences Building, New York Medical College
Valhalla, NY 10595
Graduate Degree: M.D.
Graduate Degree Institution: University of Chile
Undergraduate Institution: University of Chile