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Marta Christov, M.D., Ph.D.

Marta Christov

Assistant Professor of Medicine

Address:

Division of Nephrology
Westchester Medical Center
Macy Pavilion
Valhalla, NY 10595 

914-493-7701 (clinical)
914-594-3989 (research) 

Personal Profile:

Marta Christov, M.D., Ph.D., completed her PhD in biology at Dartmouth College in 2001 and her medical degree at Dartmouth Medical School in 2004.  After an internal medicine residency at Evanston Hospital in Evanston, IL, she completed her nephrology fellowship training at the Beth Israel Deaconess Medical Center in Boston, MA in 2010, where she stayed on as a researcher and instructor for 5 years. Dr. Christov came to Westchester Medical Center in 2015 and is an Assistant Professor of Medicine at New York Medical College/ Westchester Medical Center. She has been involved in basic and translational research for over 10 years, and is the author of over 15 peer-reviewed publications, as well as book chapters and reviews in the area of phosphate metabolism and FGF23 biology. She is a member of the American Society of Nephrology.  Dr. Christov's major areas of interest are regulation of mineral metabolism in acute kidney injury, including FGF23, the role of anemia in disturbances in mineral metabolism, and understanding the pathophysiology of vascular calcifications.

Selected Publications:

(2013-present)

* Christov, M, Waikar, SS, Pereira, RC, Havasi, A, Leaf DE, Goltzman, D, Pajevic, PD, Wolf, M, Jüppner, H. “Plasma FGF23 levels increase rapidly after acute kidney injury.” Kidney Int. 2013. Oct;84(4):776-85.

* Leaf, D, Christov, M, Jüppner, H, Siew, E Ikizler, TA, Bian, A, Chen, G, Sabbisett, V, Bonventre, J, Cai, X, Wolf, M, Waikar, SS.  “Fibroblast growth factor 23 levels are elevated and associated with severe acute kidney injury and death following cardiac surgery.”  Kidney Int. 2016 Apr;89(4):939-48

* Leaf, DE, Jacob, KA, Srivastava, A, Chen, ME, Christov, M, Jueppner, H, Sabbisetti, VS, Martin, A, Wolf, M, Waikar, SS.  “Fibroblast Growth Factor 23 Levels Associate with AKI and Death in Critical Illness.”  J Am Soc Nephrol. 2017 Jun;28(6):1877-1885.

* Knab, VM, Corbin, B, Andrukhova, O, Hum, JM, Ni, P, Rabadi, S, Maeda, A, White, KE, Erben, RG, Jueppner, H, Christov, M. “Acute parathyroid hormone injection increases c-terminal, but not intact fibroblast growth factor 23 levels.”  Endocrinology. 2017 May 1;158(5):1130-1139.

* Rabadi, S, Udo I, Leaf DE, Waikar S, Christov M. “Acute blood loss stimulates fibroblast growth factor 23 production.”  Am J Physiol Renal Physiol. 2018 Jan 1;314(1):F132-F139.

* Christov, M, Clark, AR, Corbin, B, Hakroush, S, Rhee, EP, Saito, H, Brooks, D, Hesse, E, Bouxsein, M, Galjart, N, Jung, JY, Mundel, P, Jüppner, H, Weins, A, Greka, A. “Inducible podocyte-specific deletion of CTCF drives progressive kidney disease and bone abnormalities.”  JCI Insight 2018 in press.

Invited Reviews

* Christov, M, Jüppner H. “Insights from genetic disorders of phosphate homeostasis.” Semin Nephrol. 2013 Mar;33(2):143-57.

* Christov, M, Jüppner H. “Dietary phosphate: the challenges of exploring its role in FGF23 regulation.” Kidney Int. 2013 Oct;84(4):639-41.

* Christov, M, Pereira R, Wesseling-Perry K. “Bone biopsy in renal osteodystrophy: continued insights into a complex disease.” Curr Opin Nephrol Hypertens. 2013 Mar;22(2):210-5.

* Christov, M. “FGF23 in acute kidney injury” Curr Opin Nephrol Hypertens. 2014 Jul;23(4):340-5.

Book Chapters

Christov, M. and R. Thadhani, Vitamin D in Kidney disease, chapter in “Nutritional Management of Renal Disease,” Third Ed, edited by Joel D. Kopple, Shaul G. Massry, and Kamyar Kalantar-Zadeh, 2012

Christov, M. and S. Sprague, Chronic Kidney Disease – Mineral Bone Disorder, chapter in Yu/ Brenner and Rector’s The Kidney, 11th edition, 2017

Current academic projects:

Basic science:

* Role of acute blood loss and inflammation on FGF23 production.

* Contribution of bone to FGF23 elevation in kidney disease.

Clinical research:

* Hospital-acquired anemia in dialysis patients.