Department of Cell Biology & Anatomy
Basic Sciences Building, Room 221
Valhalla, NY 10595
The Translational Stem Cell Neurobiology Laboratory studies brain disorders in which inhibitory interneuron function is compromised, such as schizophrenia, epilepsy and autism, with the aim of developing novel therapeutics for these debilitating disorders.
Inhibitory interneurons are abnormal in schizophrenic brains. To find a better way to treat schizophrenia, we need to understand what goes wrong in diseased neurons. Now we can make schizophrenia inhibitory interneurons from stem cells that are made from patient skin cells. We are studying these patient neurons to find out what is causing their abnormalities. This study could lead to novel and more effective therapies for schizophrenia.
One in 25 people experience a seizure at some point in their life and 30% of them have seizures that cannot be treated with anti-seizure medication, presenting desperate need for the development of novel and more effective treatments. We have shown that transplantation of stem cell-derived human interneurons effectively reduce seizures and other brain abnormalities in animal models of epilepsy. We are further developing this novel therapeutics for the purpose of clinical translation.
Post Graduate Studies: McLean Hospital/Harvard Medical School
Graduate Degree: Ph.D. in Neuroscience
Graduate Degree Institution: Weill Cornell Graduate School of Medical Sciences
Undergraduate Institution: Seoul National University
Chung, S., Moon, J., Leung, A. Aldrich, D., Lukianov, S., Kitayama, Y., Park, S., Li, Y., Bolshakov, V., Lamonerie, T. and Kim, K.-S. Embryonic stem cell-derived renewable and functional midbrain dopaminergic progenitors. PNAS. 2011. 108:9703.
Chung, S., Leung, A., Han, B., Chang, M., Moon, J., Kim, C., Hong, S., Pruszak, J., Isacson, O. and Kim, K.-S. Wnt1-lmx1a forms a novel autoregulatory loop and controls midbrain dopaminergic differentiation synergistically with the SHH-FoxA2 pathway. Cell Stem Cell. 2009. 5:646-58.
Kim T-G, Yao R, Cho J-H, Vasudevan A, Koh A, Moon M, Datta D, Bolshakov V, Kim K-S, Chung S. Efficient specification of interneurons from human Pluripotent stem cells by dorsoventral and rostrocaudal modulation. Stem Cells. 2014;32(7):1789-180.
Cunningham,M, Cho J-H, Leung A, Savvidis G. Ahn S, Moon M, Lee K-J, Han J, Azimi N, Kim K-S, Bolshakov V, Chung S. Human PSC-derived maturing GABAergic interneurons ameliorate seizures and abnormal behavior in epileptic mice. Cell Stem Cell. 2014;15:559-573.
Leung A, Ahn S, Savvidis G, Kim Y, Iskandar D, Luna M, Kim K-S, Cunningham M, Chung S. Optimization of pilocarpine-mediated seizure induction in immunodeficient Nod-Scid mice. Epilepsy Research. 2015;109:114-118.