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Thambi Dorai, Ph.D.

Associate Research Professor of Urology

My research interests include the molecular mechanisms of urological malignancies, such as the cancers of the prostate, kidney and bladder with a strong emphasis on cancer prevention as well as treatment strategies using naturally occurring plant based non-toxic compounds. With respect to prostate cancer, I specialize on the molecular cross talk that takes place between the prostate cancer cell and the bone cells before setting up a metastatic lesion. Interfering with this cross talk will help minimize the most devastating complication of prostate cancer, namely the establishment of osseous metastases. With respect to kidney cancer, I am interested in the strategies of altering the tumor microenvironment by modulating enzymes like Carbonic Anhydrase IX to interfere with cancer progression. With respect to bladder cancer, I collaborate within the Biochemistry and Molecular Biology Department on the clinical benefits of modulation of heat shock protein-90 (HSP-90) by histone deacetylases (HDACs).

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