Department of Pathology
Basic Sciences Building, Room 424
New York Medical College
Valhalla, NY 10595
Intern in Medicine, Department of Medicine, Barnes Hospital, St. Louis, MO. (Dr. E. Reinhard). 6/65-6/66
Staff Associate, Division of Biologics Standards, Laboratory of Bacterial Products, Section on Allergenic Extracts, National Institutes of Health, Bethesda, MD. (Dr. H. Baer). 6/66-6/70. Research on mechanisms of delayed hypersensitivity due to tuberculocarbohydrates and tuberculoproteins, pharmacokinetics of poison ivy urushiol in guinea pigs, mechanisms of contact dermatitis, standardization of ragweed and poison ivy allergenic extracts.
Moseley Travelling Fellow, Harvard Medical School, Boston, MA. 7/70-6/72. Ph.D. dissertation research with Professor P. G. H. Gell, Department of Experimental Pathology, University of Birmingham (UK) on mechanisms of delayed hypersensitivity.
Honorary Research Fellow, Department of Experimental Pathology, University of Birmingham Medical School, Birmingham, United Kingdom. 7/70-4/78.
Videnskæbelig Assistent (Assistant Professor) and Lektor (Associate Professor),Institute for Experimental Immunology, University of Copenhagen, Copenhagen, Denmark. 3/72-7/75.
Assistant Professor, Department of Pathology, State University of New York at Stony Brook, Stony Brook, NY. 7/75-6/82.
Associate Professor, Department of Pathology, New York Medical College, Valhalla, NY. 7/82-4/88.
Visiting Scientist, University Skin Clinic, Department of Experimental Dermatology, University of Münster, German Federal Republic. 2/84-3/84.
Professor, Department of Pathology, New York Medical College. Full-time. 4/88-6/91.
Visiting Scientist, Department of Pathology, University of Cambridge, Cambridge, UK. 6/88-8/88.
Professor, Department of Experimental Pathology, New York Medical College. 7/91-9/95.
Professor, Department of Pathology, New York Medical College. 9/95- .
Tuberculosis is a global public health problem, and the second most common cause of death of adults from infectious disease throughout the world (AIDS is number one). Roughly a third of the world's population is infected with Mycobacterium tuberculosis. The recent increase in the incidence of tuberculosis world-wide as a result of the HIV epidemic has led to increased interest in cellular immunity and pathogenesis in this disease. From my initial focus on biochemical mechanisms of delayed-type hypersensitivity in tuberculosis and the role of a specialized fibronectin, T cell fibronectin, in mediating this immune response, our emphasis has expanded over the years to include examination of the role of secreted mycobacterial proteins such as the fibronectin-binding antigen 85 proteins in the pathogenesis of tuberculosis, development of diagnostic reagents for active mycobacterial infection in human beings and domestic animals, as well as in captive and free-ranging wild animals that are not dependent on host immune response, delineation of a putative regulatory sequence in the mycobacterial genome and investigation of the role of interactions between mycobacterial DNA and eukaryotic transcription factors and nuclear proteins in the pathogenesis of tuberculosis.
In collaboration with Dr. Felipe Cabello of the Department of Microbiology and Immunology here at New York Medical College, we have been actively involved in analyzing the regulation of expression of a family of basic surface membrane proteins (BmpA, BmpB, BmpC, BmpD) of Borrelia burgdorferi, the spirochete that causes of Lyme disease. We have also collaborated with Dr. Cabello on developing new genetic and immunochemical tools for studying B. burgdorferi in order to analyze the genes and gene products involved in the pathogenesis of Lyme disease.
Despite our current interests in pathogenesis of infectious disease, we still retain a strong intellectual interest in the biochemical mechanisms underlying delayed hypersensitivity and contact dermatitis in human beings and animals. This has resulted in several on-going collaborative studies in this area with a number of scientists across the United States.
Post Graduate Studies: Department of Medicine, Barnes Hospital, St. Louis, MO; Division of Biologics Standards, NIH, Bethesda, MD; University of Birmingham, Birmingham, UK.
Graduate Degree: M.D., Ph.D.
Graduate Degree Institution: Harvard Medical School; University of Birmingham (UK)
Undergraduate Institution: Harvard College
C. P. Landowski, H. P. Godfrey, S. I. Bentley-Hibbert, X. Liu, Z. Huang, R. Sepulveda, K. Huygen, M. L. Gennaro, F. H. Moy, S. A. Lesley, M. Haak-Frendscho. Combinatorial use of antibodies to secreted mycobacterial proteins in a host immune system-independent test for tuberculosis. J. Clin. Microbiol. 39: 2418-2424, 2001.
X. Liu, R.K. Tiwari, J. Geliebter, J.M. Wu, H.P. Godfrey. Interaction of a Mycobacterium tuberculosis repetitive DNA sequence with eukaryotic proteins. Biochem. Biophys. Res. Comm. 320:966-972, 2004
R.C. Sizemore, M. Piva, L.T. Moore, N. Gordonov, E. Heilman, H.P. Godfrey. Modulation of delayed type hypersensitivity responses in hairless guinea pigs by peptides derived from enkephalin. Neuroimmunomodulation 11:141-148, 2004.
J.V. Bugrysheva, A.V. Bryksin, H.P. Godfrey, F.C. Cabello. 2005.Borrelia burgdorferi rel is responsible for generation of guanosine-3'-diphosphate-5'-triphosphate and growth control. Infect. Immun. 73:4972-4981.
F.C. Cabello, D. Hulinska, H.P. Godfrey, eds. Molecular Biology of Spirochetes. IOS Press, Amsterdam: 2006. i-x + 400 pp.