Dr. Haque is interested in understanding how the chemokine system promotes inflammatory responses that may promote wound repair and healing or lead to chronic disorders such as atherosclerosis. As drivers of the inflammatory response, chemokine(s) and chemokine receptors mediate this process by regulating the migration of the various leukocyte subsets through diverse G protein coupled receptors [GPCRs].
Dept. of Pathology
Basic Sciences Building Room 455
New York Medical College
Valhalla, NY 10595
How is the spatiotemporal organization of the chemokine system networked with inflammatory responses to operate together and perform diverse functions that leads to chronic disorders such as atherosclerosis? While the interplay between diverse cell types and mediators shape the atherosclerotic process, the origin of the cell(s) at the site of injury is an important determinant of the response and subsequent remodeling after an injury. This may lead to alterations in vascular smooth muscle cell (VSMC) plasticity which plays a critical role in vascular pathogenesis. As drivers of the inflammatory response, chemokine(s) and chemokine receptors mediate this process by regulating the migration of the various leukocyte subsets through diverse G protein coupled receptors [GPCRs]. Our overall aim is to identify the players involved in this process and selectively alter chemokine extracellular microenvironment and/or intracellular signaling to achieve stage-specific modulation of vascular smooth muscle cell (VSMC) phenotypes during vascular injury, remodeling and wound healing.
Graduate Degree: Ph.D.
Graduate Degree Institution: Aligarh Muslim University, Aligarh, India
Undergraduate Institution: Aligarh Muslim University, Aligarh, India
Scher, B.M., Mistry S.J., Haque N.S., Scher, W. 2010 Isolation and characterization of a large soluble form of fibronectin that stimulates adhesion, spreading, and alignment of mouse erythroleukemia cells. Exp. Cell. Res.
Qu,C., Emmerson W.E., Sanchez-Schmitz,G., Llodra, J., Sano,G, Haque N.S., Lira, S.A. and Randolph,G,R. Absence of CCR8 alters the profile of blood monocyte subsets and impairs monocyte conversion to dendritic cells. 2005. J Experimental Medicine.
Haque N.S., Fallon,J.T, Pan,J.,Taubman,M.B. and Harpel P.C. Chemokine receptor (CCR8) mediates human vascular smooth muscle cell chemotaxis and metalloproteinase-2 secretion. 2004 Blood 103 (4):1296-1304
Harpel, P.C. and Haque, N.S. Review: Chemokine Receptor-8 (CCR8): Potential Role In Atherogenesis. 2002. 4:1-3 Israel Medical Association Journal.
Haque, N.S., Fallon, J.T.,Taubman, M. and Harpel P.C. The chemokine receptor CCR8 is expressed on human endothelial cells and mediates endothelial cell chemotaxis in response to the cc chemokines I-309 and Kaposi Sarcoma Human Herpes virus encoded v-MIP-1 and to Lipoprotein(a) stimulated endothelial cell conditioned medium. 2001. Blood. 97(1):39-45
Haque, N.S, Zhang, X., Poon, M., French, D.,Taubman, M. and Harpel P.C. The CC chemokine I-309 is the principal monocyte chemoattractant induced by apolipoprotein(a) in human vascular endothelial cells. 2000 Circulation 102(7) 786-92
Haque, N.S., Buchberg, A.M. and Khalili. K. 1994. Isolation and characterization of MRF - 1, a brain derived DNA binding protein with a capacity to regulate expression of myelin basic protein gene. 1994. Journal of Biological Chemistry. 269 : 31149 – 31156
Haas, S., Haque, N.S., Khalili. K. Knobler, R.L. and Small, J. 1994 Expression of the myelin basic protein gene in transgenic mice expressing human neutrotropic virus, JCV, early protein. Virology. 202; 89 – 96
Haque, N.S., Haas, S., Knobler, R.L. and Khalili. K. Identification of a distal cis-acting regulatory element in the myelin basic protein gene. 1995. Journal of Cellular Physiology. 163: 321 – 327