NYMC > Faculty > Directory > By Name > Jiang, Houli

Houli Jiang, M.D., Ph.D.

Houli Jiang, M.D., Ph.D.‌Assistant Professor

E-mail:  houli_jiang@nymc.edu

Address:

Department of Pharmacology
Basic Science Building, Rm. 533
15 Dana Road
Valhalla, NY  10595

tel: (914) 594-4127/3117

Education:

1986      M.D.      Shanghai 2nd Mil Medical University

1992      Ph.D.     Beijing Institute of Basic Medical Sciences

Organic Analysis

Research Interests:

Our current focus is on the mechanism of vitamin C in protecting the heart from heart failure. Our findings revealed that vitamin C stimulated the production of epoxyeicosatrienoic acids (EETs) and reduced levels of 20-hydroxyeicosatetraenoic acid (20-HETE) in Sprague-Dawley rats. Moreover, vitamin C can inhibit the expression of soluble epoxide hydrolase (sEH), the main enzyme responsible for EET metabolism. Thus, our results pointed out a unique mechanism of vitamin C in protecting the heart from heart failure through regulation of vasoactive lipid mediators, i.e. by preserving EETs and reducing 20-HETE. EETs are vasodilator, anti-inflammatory and antihypertensive lipid mediators, while 20-HETE is a vasoconstrictor, pro-inflammatory and pro-hypertensive lipid mediator produced by cytochrome P450 from arachidonic acid. The novel mechanism is consistent with reduced levels of EETs in cardiovascular diseases, the cardio-protective effects of EETs and a significant correlation of increased vitamin C with reduced incidences of heart failure. Our study suggested a prospect of combining vitamin C analogs with sEH inhibition for the prevention and treatment of heart failure.

Selected Publications:

  1. Kandhi S, Qin J, Froogh G, Jiang H, Luo M, Wolin MS, Huang A, Sun D. EET-dependent potentiation of pulmonary arterial pressure: Sex different regulation of soluble epoxide hydrolase. Am J Physiol Lung Cell Mol Physiol. 309(12):L1478-86, 2015.
  2. Qin J, Kandhi S, Froogh G, Jiang H, Luo M, Sun D, Huang A. Sexually dimorphic phenotype of arteriolar responsiveness to shear stress in soluble epoxide hydrolase-knockout mice. Am J Physiol Heart Circ Physiol. 309(11):H1860-6, 2015.
  3. Jiang H, McGiff JC, Fava C, Amen G, Nesta E, Zanconato G, Quilley J, Minuz P. Maternal and fetal epoxyeicosatrienoic acids in normotensive and preeclamptic pregnancies. Am J Hypertens. 26:271-278, 2013.
  4. Jiang H, Harrison FE, Jain K, Benjamin S, May JM, Graves JP, Zeldin DC, Falck J, Hammock BD, McGiff JC. Vitamin C activation of the biosynthesis of epoxyeicosatrienoic acids. Adv Bioscience Biotechnology. 3:204-218, 2012.

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