Telephone: (914) 594-4259
Department of Environmental Health Science
School of Health Sciences and Practice
New York Medical College
30 Plaza West, Vosburgh Rm 110,
Valhalla, NY 10595
Dr. Kim received his PhD on 1996 from the Department of Pharmaceutical Sciences, University of Tokyo, and Tokyo, Japan. He completed his postdoctoral fellowship training in both academic and biotechnology & pharmaceutical companies in Japan, South Korea and USA. He has experience in several scientific backgrounds in the fields of molecular, neurobiology, cancer pharmacology such as multidrug resistance in solid cancers, vaccine development for AD and infectious disease, and innate immunity in AD. He has been widely respected for his discovery with regard to the development of antibody against beta amyloid in Alzheimer disease (AD) which develops novel antibody as counteract neurotoxicity due to misfolding of beta amyloid protein and demeliolate of Abeta to neuronal cells which results in memory loss. Alzheimer's disease (AD) is a growing social concern and the most common type of dementia in the elderly along with genetic and environmental risk variations which accelerates oxidative stress mediated production of toxic and misfolding protein such as beta amyloid which slowly causes progressive neurodegenerative disease. Even though there is a growing life expectancy (demographic transition) with better medicine, prognostic, diagnostic tool and advocacy of public health prevention, there are currently 4 million Americans diagnosed with AD and approximately more than 500,000 new cases per year. Dr. Kim’s research interest will serve as a proof of principle to demonstrate whether our novel immune gene therapy modality with good epitope is effective in treating an animal model of AD. Since 2008, Dr. Kim has also participates in the Rutgers CounterACT Center of excellence (PI. Dr. Heck) contributing his expertise in molecular biology and pharmaceutical biologics to the group. Dr. Kim believes that his insights into the complexity of commercial development and production of biologics has been helpful in speeding approaches to product selection and may have assisted the Center in avoiding costly mistakes. He has also developed and conducted mechanism-based screening assay to evaluate drug candidates, assisted in the development of animal models and adapted techniques for the evaluation of potential drug product efficacy. Currently he is refining animal models for mustard toxicity and adapting the technology for exploring microRNA as regulators, and then developed for vaccine production toward enhance wound healing and limit toxicity resulting from exposure to mustard vesicants as counteract measures. He is gratified that many of the students under his mentorship have moved on to join emerging biotechnology entities and important biologics such as single chain antibody or explore biomarker to detection early or therapy in diseases such as Skin cancer, neurodegenerative disorders including heavy metal toxicity.
Dr. Kim’s aspiration is to teach health care leaders (M.P.H., M.D., and M.P.H./M.D.) who are able to provide resolution from insightful approaches from observing environmental issues globally and learning to dissect disease molecular level bridged with evaluation and monitoring technology include molecular communication and interaction biology by defining environmental risk factors to health and interpreting big data how to molecular change be affected through build-up practicum research to accomplish academic strengths overarching Environmental and Occupational issues which could be resolved after applied with OMICS concept (i.e., Genomics, epigenomes, Proteomics, metabolomics, pharmacogenomics, and Glycomics) which would necessary to cope with unknown pathogen, environmental stressor, hazardous chemical exposure by improve measurement, validation on safety issue and prediction risk as molecular assessment tool in the field of occupational, industrial hygiene, and environmental Health Science.
Project highlighted during Post-doctoral Research Training
Hong-Duck Kim, Akihiro Tomida, Takashi Tsuruo: Glucose-regulated stresses cause degradation of DNA topoisomerase II alpha by inducing nuclear proteasome during G1 cell cycle arrest in cancer cells. J Cell Physiol July;180 (1):97-104, 1999.
Okabe S., Kim H.D., Miwa A., Kuriu T. and Okado H. Continual remodeling of postsynaptic density and its resulation by synaptic activity. Nat Neurosci Sep; 2(9):804-811, 1999.
Lalonde, R., Kim, H.D., Fukuchi, K., Exploratory activity, anxiety, and motor coordination in bigenic APPswe+PS1/deltaE9 mice. Neurosci Lett 369:156-161, 2004.
Kim H.D., Kong, F.K., Cao Y., Lewis T., Kim H., Tang D.C., and Fukuchi, K. Immunization of Alzheimer model mice with adenovirus vectors encoding amyloid -protein and GM-CSF reduces amyloid load in the brain. Neurosci Lett 370:218-223, 2004.
Kim H.D., Cao Y., Kong, F.K., Lewis, T., Van Kampen, K.R., Lewis, T.L., Ma, Z., Tang D.C., and Fukuchi, K. Induction of a Th2 immune response by co-administration of recombinant adenovirus vectors encoding amyloid -protein and GM-CSF. Vaccine 23:2977-2986, 2005.
Kim, HD, Maxwell JA, Kong FK, Tang DC, Fukuchi, K., Induction of anti-inflammatory immune response by an adenovirus vector encoding 11 tandem repeats of Abeta1-6; toward safer and effective vaccines against Alzheimer’s Disease Biochem Biophys Res Commum 336(1):84-92, 2005.
Fukuchi K, Accavitti-Loper MA, Kim HD, Tahara K, Cao Y, Lewis TL, Caughey RC, Kim H, Lalonde R. Amelioration of amyloid load by anti-Abeta single-chain antibody in Alzheimer mouse model. Biochem Biophys Res Commun. 2006 May 26; 344(1):79-86.
Fukuchi KI, Tahara K, Kim HD, Maxwell JA, Lewis TL, Accavitti-Loper MA, Kim H, Ponnazhagan S and Robert Lalonde R Anti-Aβ single-chain antibody delivery via adeno-associated virus for treatment of Alzheimer's Disease Neurobiology of Disease 2006 Jun 9;25(3):502-511
Tahara K, Kim HD, Jin JJ, Maxwell JA, LI L, Fukuchi K. Role of toll-like receptor signaling in Aß uptake and clearance. Brain 2006 Nov; 129 (Pt 11):3006-19. Epub 2006 Sep 19.
Kim HD, Tahara K, Maxwell JA, Lalonde R, Fukuiwa T, Fujihashi K, Van Kampen KR, Kong FK, Tang DC, Fukuchi KI. Nasal inoculation of an adenovirus vector encoding 11 tandem repeats of Abeta1-6 upregulates IL-10 expression and reduces amyloid load in a Mo/Hu APPswe PS1dE9 mouse model of Alzheimer's Disease. J Gene Med. 2007 Feb 9(2); 88-98
Kim HD, Jin JJ, Maxwell JA, Fukuchi KI. Enhancing Th2 immune responses against amyloid protein by a DNA prime-adenovirus boost regimen for Alzheimer’s disease. Immunology Letters 112(2007), 30-38.
Jin JJ, Kim HD, Maxwell JA, Li L, Fukuchi K. Toll-like receptor 4-dependent upregulation of cytokines in a Transgenic mouse model of Alzheimer Disease. Journal of Neuroinflammation 2008 May 5(23); 1-10
Heck DE, Sharkarjian MP, Kim HD, Laskin JD, and Vetrano AM. Mechanisms of Oxidants generation by catalase. Ann. N.Y. Acad.Sci. 2010 1203; 120-125
Kou JH, Kim HD, Jin JG, Cao DF, Li L, Lalonde R., and Fukuchi K. Simvastatin enhances immune responses to Aβ vaccination and attenuates vaccination-induced behavioral alterations. Brain Res. 2010 Oct 14; 1356:102-11
Jinghong Kou, HongDuck Kim, Abhinandan Pattanayak, Min Song, Jeong-Eun Lim, Hiroaki Taguchi, Sudhir Paul, John R. Cirrito, Selvarangan Ponnazhagan and Ken-ichiro Fukuchi.. Anti-Amyloid-β Single –Chain Antibody Brain Delivery Via AAV Reduces Amyloid Load But May Increase Cerebral Hemorrhage in an Alzheimer’s disease Mouse Model. Journal of Alzheimer’s Disease 1 (2011) 1-16
Song M, Jin J, Lim JE, Kou J, Pattanayak A, Rehman JA, Kim HD, Tahara K, Lalonde R, Fukuchi KI. TLR4 mutation reduces microglial activation, increases Abeta deposits and exacerbates cognitive deficits in a mouse model of Alzheimer's disease. J Neuroinflammation. 2011 Aug 9; 8(1):92
Heck, DE, Joseph LB, Kim H-D, Biomarkers of Dermal Toxicity in Biomarkers in Toxicology, edited by Ramesh Gupta, Oct. 2013, p 310-315, Elsevier, NY.
Park HJ, Yun J, Jang SH, Kang SN, Jeon BS, Ko YG, Kim HD, Won CK, Kim GS, Cho JH. Coprinus comatus Cap Inhibits Adipocyte Differentiation via Regulation of PPARγ and Akt Signaling Pathway. PLoS One. 2014 Sep 2;9(9):e105809.
Song Y, Kim HD, Lee MK, Kim MK, Kang SN, Ko YG, Won CK, Kim GS, Lee SS, Bai HW, Chung BY, Cho JH. Protective effect of centipedegrass against Aβ oligomerization and Aβ-mediated cell death in PC12 cells. Pharm Biol. 2015;53(9):1260-6.
Hong-Duck Kim, Jae-Hyeon Cho, and Diane E. Heck. '"Stimulation of Vitamin D response element coupled with fatty acid amide hydrolase mitigate Lead Acetate-mediated oxidative stress in mouse keratinocyte Pam212 cell"' THE GENE-ENVIRONMENT INTERACTIONS. May 02.2016 published on-line