Telephone: (914) 594-3733
Division of Hematology, Oncology and Stem Cell Transplantation
Department of Pediatrics
Vosburgh Pavilion, Room 101
Valhalla, NY 10595
My research interest is focused on pediatric solid tumors. For basic science research, I am particularly interested in the molecular biology of oncogenesis and drug resistance in Ewing sarcoma, an aggressive pediatric bone and soft tissue tumor. For translational research, I am exploring the feasibility of DC-based pediatric brain tumor vaccine.
Post Graduate Studies: University of Utah, Huntsman Cancer Institute (Drs. David Virshup and Stephen Lessnick)
Graduate Degree: Ph.D.
Graduate Degree Institution: Xiamen University School of Life Sciences (Dr. Sheng-Cai Lin), Xiamen, China
Undergraduate Institution: Nanchang University, Nanchang, China
Sankar S, Gomez NC, Bell R, Patel M, Davis IJ, Lessnick SL, and Luo W. EWS and RE1-silencing transcription factor inhibit neuronal phenotype development and oncogenic transformation in Ewing sarcoma. Genes & Cancer. 2013, doi: 10.1177/1947601913489569
Luo W, Milash B, Dalley B, Smith R, Zhou H, Dutrow N, Cairns BR, and Lessnick SL. Antibody detection of translocations in Ewing sarcoma. EMBO Mol. Med. 2012, 4: 1-9.
Luo W, Kinsey M, Schiffman JD and Lessnick SL. Glutathione S-transferases in pediatric cancer. Front. Oncol. 1:39. doi: 10.3389/fonc.2011.00039
Luo W, Gangwal K, Sankar S, Boucher KM, Thomas D, Lessnick SL. GSTM4 is a microsatellite-containing EWS/FLI target involved in Ewing’s sarcoma oncogenesis and therapeutic resistance. Oncogene. 2009, 28: 4126-4132.
Jiang Y, Luo W, Howe PH. Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing protein phosphatase 1 (PP1)-Axin interactions. Oncogene. 2009, 28: 2999-3007.
Luo W, Peterson A, Garcia BA, Coombs G, Kofahl B, Heinrich R, Shabanowitz J, Hunt DF, Yost HJ, Virshup DM. Protein phosphatase 1 regulates assembly and function of the -catenin degradation complex. EMBO J. 2007, 26: 1511-1521.
Luo W, Zou H, Jin L, Lin S, Li Q, Ye Z, Rui H, Lin SC. Axin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functions. J Biol Chem. 2005, 280:5054-5060.
Wong CK*, Luo W*, Deng Y, Zou H, Ye Z, Lin SC. The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms. J Biol Chem. 2004, 279:39366-39373.(*equal authorship)
Luo W, Ng WW, Jin LH, Ye Z, Han J, Lin SC. Axin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activation. J Biol Chem. 2003, 278:37451-37458.
Luo W, Lin SC. Axin: a master scaffold for multiple signaling pathways. Neurosignals 2004, 13:99-113.