NYMC > Faculty > Directory > By Name > Vinukonda, Govindaiah

Govindaiah Vinukonda, M.Sc. Ph.D.

Assistant Professor, Pediatrics-Newborn Medicine and Cell Biology & Anatomy

Email: g_vinukonda@nymc.edu

Phone: 914-594-4661 (lab)

Address:

Department of Pediatrics and Cell Biology & Anatomy
Basic Science Building, Room # AO3
New York Medical College
Valhalla, NY 10595
Tel: (914) 594-4661
Fax: (914) 594-4653

Professional Interests:

Our research studies focuses on the pathogenesis of intraventricular hemorrhage (IVH) and development of neuro-protective strategies to prevent brain damage after IVH in premature infants. Current therapeutic strategies to treat IVH or prevent the resultant white matter brain injury have been largely unsuccessful.

Stem cells of different sources, such as human cord blood (CB) mononuclear cells, CD34+ CB and mesenchymal stem cells (MSCs) offer great promises in the treatment of a variety of neurological disorders on both preclinical and clinical studies. There have been no published investigations on the safety and efficacy of stem cell therapy in IVH. Our laboratory research is focusing to determine the safety and efficacy of stem cells with regenerative properties in a rabbit model of IVH. Our research goal are to evaluate pathologies associate with brain hemorrhage. And to improve the brain developmental outcome using genetic, pharmacological and stem cell therapeutic approaches after intraventricular hemorrhage in a translational premature rabbit model. Our work is related to both the aspect of research of neonatal brain development and neurological disorders. Dr. Vinukonda is awardee of Scientist Development Grant Award from American heart Association at national level.

  1. Germinal matrix-intraventricular hemorrhage (GMH-IVH): Investigating potential therapeutic approaches for the treatment of pathogenesis of intraventricular hemorrhage (IVH) causing- white matter injury, reduced neurogenesis and post hemorrhagic hydrocephalus.
  2. Novel Stem Cell therapy for germinal matrix-intraventricular hemorrhage (GMH-IVH): Investigating pathogenesis of (IVH), post hemorrhagic hydrocephalus, and white matter injury.
  3. Consequences of glycerol induced diffused alveolar hemorrhage in premature rabbit pup model and treatment approaches for lung damage: Diffused alveolar is bleeding from many alveolar spaces throughout the lungs. Premature infants commonly associated with pulmonary and diffused alveolar hemorrhage and it occurrence is 1 in 1000 births. The common problem associated with alveoli hemorrhage is pulmonary edema, fibrosis, hypoxia and acute inflammation causing the lung damage. There is no well-established animal model of diffused alveolar hemorrhage to study the lung damage caused by blood and blood born components in prematurity. We have developed i.p. glycerol induced diffused alveolar hemorrhage in premature rabbit pups.

Education Profile:

Graduate Degrees: M.Sc., Ph.D.

Graduate Degree Institution: College of Science & Technology., Andhra University, Visakhapatnam, Andhra Pradesh, India

Post Graduate Studies:

Graduate Degree (Bachelor’s in Chemistry and Biology)
College of Science & Technology, Andhra University, 1985-1988, Visakhapatnam, India

Post Graduate Degree (Master’s in Human Genetics)
College of Science & Technology, Andhra University, 1989-1991, Visakhapatnam, India

Post-doctoral Fellowship (Cancer Biology and Pharmacology)
University of Illinois, College of Medicine at Peoria, 2003, Peoria, IL, USA

Research Associate (Pathology)
Department of Pathology, 2003-2006, New York Medical College, Valhalla, NY

Selected Bibliography:

Purohit D, Finkel DA, Malfa A, et al. Human Cord Blood Derived Unrestricted Somatic Stem Cells Restore Aquaporin Channel Expression, Reduce Inflammation and Inhibit the Development of Hydrocephalus After Experimentally Induced Perinatal Intraventricular Hemorrhage. Front Cell Neurosci. 2021;15:633185. Published 2021 Apr 9. doi:10.3389/fncel.2021.633185.

Vinukonda G, Liao Y, Hu F, et al. Human Cord Blood-Derived Unrestricted Somatic Stem Cell Infusion Improves Neurobehavioral Outcome in a Rabbit Model of Intraventricular Hemorrhage. Stem Cells Transl Med. 2019;8(11):1157-1169. doi:10.1002/sctm.19-0082

Vinukonda, G, Hu F, Mehdizadeh R, Dohare P, Kidwai A, Juneja A, Naran V, Kierstead M, Chawla R, Kayton R, Ballabh P. (2016). Epidermal growth factor preserves myelin and promotes astrogliosis after intraventricular hemorrhage. Glia. 2016 Nov; 64(11):1987-2004. PMID: 27472419.

Vinukonda, G, Dohare P, Arshad A, Zia MT, Panda S, Korumilli R, Kayton R, Hascall V, Lauer M and Ballabh P. (2016). Hyaluronidase and Hyaluronan Oligosaccharides Promote Neurological Recovery after Intraventricular Hemorrhage. The Journal of Neuroscience, 36(3):872– 889. PMID: 26791217.

Arshad A, Vose LR, Vinukonda G, Hu F, Yoshikawa K, Csiszar A, Brumberg JC, Ballabh P.(2015). Extended Production of Cortical Interneurons into the Third Trimester of Human Gestation. Cereb Cortex. Apr 16. PMID: 25882040.

Vose LR, Vinukonda G, Diamond D, Korumilli R, Hu F, Zia MT, Hevner R, Ballabh P. (2014). Prenatal betamethasone does not affect glutamatergic or GABAergic neurogenesis in preterm newborns. Neuroscience. Jun 13; 270:148-57. PMID: 24735821.

Vose L, Vinukonda G, Jo S, Miry O, Diamond D, Korumilli R, Arshad A, Zia M, Hu F, Kayton R, LaGamma Ed, Bansal R, Bianco A, and Ballabh P. (2013). Treatment with thyroxine restores myelination and clinical recovery after intraventricular hemorrhage. J. Neuroscience. Oct 30; 33(44):17232-46. PMID: 24174657.

Vinukonda G, Zia MT, Bhimavarapu BB, Hu F, Feinberg M, Bokhari A, Ungvari Z, Fried VA, Ballabh P. (2013). Intraventricular hemorrhage induces deposition of proteoglycans in premature rabbits, but their in vivo degradation with chondroitinase does not restore myelination, ventricle size and neurological recovery. Exp. Neurol. 247:630-644. PMID: 23474192.

Malik S, Vinukonda G, Vose L, Diamond D, Bhimavarapu B, Hu F, Zia MT, Hevner R, Zecevic N, and Ballabh P. (2013). Neurogenesis Continues in the Third Trimester of Pregnancy and Is Suppressed by Premature Birth. J. Neuroscience. 33(2):411– 423. PMID: 23303921.

Vinukonda G, Hu F, Upreti C, Ungvari Z, Zia MT, Stanton PK, Ballabh P. (2012) Novel organotypic in vitro slice culture model for intraventricular Hemorrhage. J Neurosci Res. 90(11):2173-82. PMID: 22806625

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