NYMC > Faculty > Directory > By Name > Wang, Penghua

Penghua Wang, Ph.D.

Assistant Professor, Microbiology and Immunology

Email: Penghua_wang@nymc.edu


Dept. of Microbiology & Immunology
Basic Sciences Building Room 348 
New York Medical College
Valhalla, NY 10595

Professional Interests:

I am primarily interested in host-pathogen interaction, with a focus on vector-borne RNA viruses in vivo and in vitro. Specifically, I wish to understand pathogenic mechanisms of viral infection at the cellular and animal levels, and study the molecular function of host genes that influence viral pathogenesis and the disease outcomes. On the host side, I am keen on the innate immune system, detection of viruses and initiation of antiviral immune responses.  On the viral side, I wish to understand the mechanisms of immune evasion. My recent work is focused on the RIG-I like receptor signaling pathways and their regulation, the physiological functions of NOD-like receptors in limiting West Nile virus/Chikungunya virus infection, and the unappreciated functions of UBXNs in immune regulation.

Education Profile:

Graduate Degree: Ph.D.
Graduate Degree Institution: The National University of Singapore, Republic of Singapore 
Undergraduate Institution: Sun Yat-sen University, Guangzhou, P.R. China, BSc, Biochemistry

Selected Bibliography:

Penghua Wang, Shu Zhu,  Long Yang, Shuang Cui, Wen Pan, Ruaidhri Jackson, Yunjiang Zheng, Anthony Rongvaux, Qiangming Sun, Guang Yang, Shandian Gao, Rongtuan Lin, Fuping You, Richard Flavell, Erol Fikrig. Science.  Oct 2015, aab3145.

Xiaoping Xiao, Rudian Zhang, Xiaojing Pang, Guodong Liang, Penghua Wang, Gong Cheng. A Neuron-Specific Antiviral Mechanism Prevents Lethal Flaviviral Infection of Mosquitoes. PLoS Pathog2015; 11(4): e1004848.

Xiaoping Xiao, Yang Liu, Xiaoyan Zhang, Jing Wang, Zuofeng Li, Xiaojing Pang, Penghua Wang, Gong Cheng. Complement-Related Proteins Control the Flavivirus Infection of Aedes aegypti by Inducing Antimicrobial Peptides. PLoS Pathog 2014; 10(4): e1004027.

Yang Liu, Fuchun Zhang, Jianying Liu, Xiaoping Xiao, Siyin Zhang,, Chengfeng Qin, Ye Xiang, Penghua Wang Gong Cheng. Transmission-Blocking Antibodies against Mosquito C-Type Lectins for Dengue Prevention. PLoS Pathog 2014; 10 (2): e1003931.

Fuping You, Penghua Wang, Long Yang, Guang Yang, Erol Fikrig. ELF4 is a transactivator of type IFNs. Nature Immunology 2013; 14:1237-1246.
Penghua Wang, Long Yang, Gong Cheng, Erol Fikrig and Richard Sutton. UBXN1 interferes with RIG-I like receptor signaling. Cell Reports 2013; 3 (4):1057–1070.

Penghua Wang (correspondence author), Fengwei Bai , Lauren A. Zenewicz, Jianfeng Dai, Long Yang, David Gate, Eric Cheng, Richard A. Flavell, Terrence Town, Erol Fikrig.  IL-22 contributes to West Nile virus encephalitis via neutrophils. PLoS ONE 2012, 7(8): e44153.

Dai J, Pan W, Wang P. ISG15 facilitates cellular antiviral response to dengue and west nile virus infection in vitro. Virol J. 2011, 13;8:468.

Tonya M. Colpitts, Jonathan Cox, Dana L. Vanlandingham, Fabiana M. Feitosa Gong Cheng, Sebastian Kurscheid, Penghua Wang, Manoj N. Krishnan, Stephen Higgs, Erol Fikrig. Alterations in the Aedes aegypti Transcriptome during Infection with West Nile, Dengue and Yellow Fever Viruses.PLoS Pathog 2011, 7(9):e1002189.

Colpitts TM, Barthel S, Wang P, Fikrig E. Dengue virus capsid protein binds core histones and inhibits nucleosome formation in human liver cells. PLoS One. 2011;6(9):e24365.

Cheng G, Liu L, Wang P, Zhang Y, Zhao YO, et al. (2011) An In VivoTransfection Approach Elucidates a Role for Aedes aegyptiThioester-Containing Proteins in Flaviviral Infection. PLoS ONE 2011. 6(7): e22786.

Arjona A, Wang P (equal contribution), Montgomery RR, Fikrig E. Innate Immune Control of West Nile Virus Infection. Cell Microbiol. 2011 Jul 25. doi: 10.1111/j.1462-5822.2011.01649.x.

Colpitts TM, Rodenhuis-Zybert I,Moesker B, Wang P, Fikrig E, Smit J. PrM-antibody renders immature West Nile virus infectious in vivo.J Gen Virol 2011 vir.0.031427-0.

Jianfeng Dai, Sukanya Narasimhan, Lili Zhang, Lei Liu, Penghua Wang, Erol Fikrig. Tick Histamine Release Factor Is Critical forIxodes scapularis Engorgement and Transmission of the Lyme Disease Agent. PLoS Pathog  2010, 6(11): e1001205

Penghua Wang, Alvaro Arjona, Yue Zhang, Hameeda Sultana, Jianfeng Dai, Long Yang, Philippe LeBlanc, Karine Doiron, Maya Saleh, Erol Fikrig. Caspase-12 controls West Nile virus infection via the RNA receptor RIG-I. Nature Immunology, 2010, 11(10):912-919.  Selected paper in Faculty 1000.

Gong Cheng, Jonathan Cox, Penghua Wang, Manoj N. Krishnan, Jianfeng Dai, Feng Qian, John F. Anderson and Erol Fikrig. A mosquito C-type lectin facilitates West Nile virus infection via a CD45 homologue. Cell 2010,142(5):714-25

Jianfeng Dai, Penghua Wang, Sarojini Adusumilli, Carmen Booth, Justin D. Radolf, Sukanya Narasimhan, Juan Anguita, and Erol Fikrig. Antibodies against a tick protein, Salp15, protect mice from the Lyme disease agent. Cell Host & Microbe 2009, 6(5):482-92.

Fengwei Bai , Feng Qian,  Terrence Town, Masahito Kamanaka, Tarah M. Connolly,Penghua Wang , Ruth R. Montgomery, Richard A. Flavell and Erol Fikrig.  Blockade of regulatory T cell-induced IL-10 helps control murine West Nile virus infection. PLoS Pathogen2009, 5(10):e1000610

Joppe W.R. Hovius, Maarten F. Bijlsma , W. Joost Wiersinga, Gerritje J van der Windt, Bas Boukens , Jeroen Coumou, Anneke Oei, Regina de Beer, Alex F. de Vos, Cornelius van 't Veer, Alje P. van Dam, Penghua Wang, Erol Fikrig, Marcel M. Levi, Joris J. Roelofs, Tom van der Poll. The Urokinase receptor (uPAR) Facilitates Clearance of Borrelia burgdorferiPLoS Pathogen 2009, 5(5):e1000447.

Pal U, Wang P (co-first), Bao F, Yang X, Samanta S, Schoen R, Wormser GP, Schwartz I, Fikrig E.Borrelia burgdorferi basic membrane protein BmpA/B are critical for Lyme arthritis. J. Exp. Med. 2008, 205(1): 133-41. 
Commented by Nature Clinical Practice Rheumatology(2008) 4: 230

Wang P, Dai J, Bai F, Kong KF, Wong SJ, Montgomery RR, Madri JA, Fikrig E.Matrix Metalloproteinase 9 Facilitates West Nile Virus Entry into the Brain. J. Virol.  2008, 82(18):8978-85.

Dai J, Wang P, Bai F, Town T, Fikrig E. Icam-1 participates in the entry of west nile virus into the central nervous system. J. Virol. 2008, 82(8): 4164-8.

Pal U, Dai J, Li X, Neelakanta G, Luo P, Kumar M, Wang P, Yang X, Anderson JF, Fikrig E. A differential role for BB0365 in the persistence of Borrelia. A differential role for BB0365 in the persistence of Borrelia burgdorferi in mice and ticks. J. Infect. Dis. 2008; 197(1): 148-55.

Yang X, Izadi H, Coleman AS, Wang P, Ma Y, Fikrig E, Anguita J, Pal U. Borrelia burgdorferi lipoprotein BmpA activates pro-inflammatory responses in human synovial cells through a protein moiety. Microbes Infect. 2008,10(12-13):1300-8.

Wang Q, Zengin A, Ying W, Newell KA, Wang P, Yeo W, Wong PT, Yenari MA, Huang XF. Chronic treatment with simvastatin upregulates muscarinic M1/4 receptor binding in the rat brain.Neuroscience. 2008, 154(3):1100-6.

Penghua Wang, Yong Zhang, Hongzhe Li, Hai Kee Chieu, Alan L. Munn and Hongyuan Yang. AAA ATPases Regulate Membrane Association of Yeast   Oxysterol Binding Proteins and Sterol Metabolism. EMBO J.  2005, 24: 2989-2999.

Penghua Wang, Wei Duan, Alan L. Munn and Hongyuan Yang. Molecular Characterization of Osh6p, an Oxysterol Binding Protein Homolog in the Yeast Saccharomyces cerevisiae. FEBS J. 2005, 272: 4703-15. 

Wang Q, Wang PH, McLachlan C, Wong PTSimvastatin reverses the downregulation of dopamine D1 and D2 receptor expression in the prefrontal cortex of 6-hydroxydopamine-induced Parkinsonian rats.Brain Res. 2005, 1045(1-2): 229-33.

Book chapters:
Penghua Wang (correspondence author) and Qing Wang. Invasion of brain by viruses. New Frontiers in Neurological Research, 2008: ISBN: 978-81-308-0284-8 by Research Signpost.

Qing Wang, Penghua Wang, Weihai Ying and Peter T.-H. Wong. The neuroinflammatory mechanisms in Parkinson's disease New Frontiers in Neurological Research, 2008: ISBN: 978-81-308-0284-8 by Research Signpost 

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