Education
- Postdoctoral Fellowship, Physiology and Biochemistry, Harvard Medical School
- Ph.D., Biophysics, University of Chicago
- B.S., Physics, Rensselaer Polytechnic Institute
Areas of Expertise
- Skeletal Muscle Growth and Atrophy
- Molecular Mechanisms
- Selectivity of Intracellular Proteolysis in Erythroid and Muscle Cells
- Role of Proteasomes and Ubiquitin
- Spinal Cord Injury
- Pulmonary Hypertension
- General Human Biology
Honors and Awards
- Established Investigator of the American Heart Association
- Irma T. Hirschl Award, Principal Investigator on grants from NIH, NASA and MDA
Research
With Alfred L. Goldberg, Joseph Etlinger, Ph.D., discovered non-lysosomal ATP-dependent proteolytic activity, credited by awardees of the 2004 Nobel Prize in chemistry, as the seminal observation revealing the proteasome/ubiquitin system. In subsequent studies, with his students and colleagues, novel factors involved in the regulation of this pathway, including a ubiquitin ligase critical to pulmonary arterial hypertension, were identified. Dr. Etlinger proposed how myofibrils turn over during muscle growth and atrophy and the roles of calcium, ATP, and beta-adrenergic receptors in these conditions. Finally, he identified modalities to improve recovery from spinal cord injury, including beta-agonists, x-irradiation, and inhibitors of glucose toxicity.
Publications
Teaching Responsibilities
- Medical Cell Biology and Anatomy
- Graduate Histology and Graduate Cell Biology
- Dental Histology
- Cell Biology Topics
- Journal Club
