Julian M. Stewart, M.D., Ph.D., directs the Center for Hypotension, which has had NIH funding for 24 years. He is trained in medicine, integrative physiology, and computer based biophysical methods. Dr. Stewart's laboratory has been studying orthostatic intolerance in conscious humans for more than 20 years with a particular focus on circulatory regulation in orthostatic intolerance (OI). Chronic OI is better known as postural tachycardia syndrome (POTS). His research has contributed to literature regarding measurements of systemic vascular resistance, cardiac output, and venous capacitance as well as microvascular properties. Recently, Dr. Stewart's research has been focused on connections between hypocapnia, hypercapnia, hyperventilation, and impaired cognition, cardiovagal baroreflexes, cerebral autoregulation, splanchnic vasoconstriction and venoconstriction, and enhanced sympathetic activity in OI patients.
Education
- A.B., Physics, Cornell University
- M.D., University of Chicago
- Ph.D., University of Chicago
- Postdoc, Pediatric Cardiology, New York Hospital-Cornell University
- Residency, Physiology/Biophysics, NYU Medical Center
- Fellowship, Pediatric Cardiology, New York Hospital-Cornell University
Areas of Expertise
- Pediatrics/Pediatric Cardiology
- Hypotension
- DOD Gulf War Syndrome
- CFS/Fibromyalgia
Research
Research interests include computational circulatory physiology investigating vascular and cardiac properties in animal model systems as well as during diagnostic procedures such as cardiac catheterization and flow-volume monitoring and redistribution in critically ill infants and children. Correlative work studying the relation of cardiovascular properties to nitric oxide physiology is in progress. Recent work has also included connections of peripheral flow and muscle pump activity with osteoporosis, and contractual work with the Department of Defense related to muscular dystrophy.
Publications
- Glen RC, Cole JC, Stewart JJP, et. al. "Prediction of enzyme inhibition (IC(50)) using a combination of protein-ligand docking and semiempirical quantum mechanics." Journal of molecular modeling, 31(8), (2025) 209. doi: 10.1007/s00894-025-06423-7
- Mir M, Soto F, Gomez PAA, et. al. "Correction: Bronchoalveolar lavage cell percentages as diagnostic markers of immune checkpoint inhibitor pneumonitis." Frontiers in medicine, 12(), (2025) 1646108. doi: 10.3389/fmed.2025.1646108
- Gillessen S, Murphy L, James ND, et. al. "Metformin for patients with metastatic prostate cancer starting androgen deprivation therapy: a randomised phase 3 trial of the STAMPEDE platform protocol." The Lancet. Oncology, (), (2025) . pii: S1470-2045(25)00231-1. doi: 10.1016/S1470-2045(25)00231-1
- Jayanthi R, Rajagopal D, Alami AK, et. al. "Evoque Tricuspid Replacement in a Patient With Failed Cardioband Transcatheter Tricuspid Annuloplasty." JACC. Cardiovascular interventions, (), (2025) . pii: S1936-8798(25)01434-7. doi: 10.1016/j.jcin.2025.05.022
- Stewart JH 4th, Castater CA, Oppong BA, et. al. "Statement from the Society of Black Academic Surgeons (SBAS) affirming our commitment to excellence for all." American journal of surgery, (), (2025) 116503. doi: 10.1016/j.amjsurg.2025.116503
- Mogaka FO, Kwach B, Odira A, et. al. "Stakeholder perspectives on integrating doxycycline postexposure prophylaxis into Kenyan HIV PrEP programmes." Sexually transmitted infections, (), (2025) . pii: sextrans-2025-056535. doi: 10.1136/sextrans-2025-056535
- Kwach B, Kwena Z, Violette LR, et. al. "Understanding barriers and facilitators to doxycycline post-exposure prophylaxis adherence among young women in western kenya: a qualitative study." BMC infectious diseases, 25(1), (2025) 855. doi: 10.1186/s12879-025-11209-6
Professional Service
- CDC-NIH Committee on Chronic Fatigue in Adolescents
- NIH/NIAID Special Emphasis Panel
- Ad Hoc Reviewer CVS-A
- Reviewer CICS
- Associate Chair IRB
