Pascale JV, Park EJ, Adebesin AM, Falck JR, Schwartzman ML, and Garcia V. Uncovering the signaling, structure and function of the 20-HETE-GPR75 pairing: Identifying CCL5 as a negative regulator of GPR75. British Journal of Pharmacology (BJP). May 2021.
Pascale JV, Lucchesi PA and Garcia V. Unraveling the role of 12- and 20-HETE in cardiac pathophysiology: G-protein coupled receptors, pharmacological inhibitors and transgenic approaches. Journal of Cardiovascular Pharmacology. March 2021
Gilani A, Agostinucci K, Hossain S, Pascale JV, Garcia V, Adebesin AM, Falck JR, and Schwartzman ML. 20-HETE interferes with insulin signaling and contributes to obesity-drive insulin resistance. Prostaglandins and Other Lipid Mediators (POLM). October 2020.
Gilani A, Agostinucci K, Pascale JV, Hossain S, Kandhi S, Pandey V, Garcia V, Nasjletti A, and Schwartzman ML. Proximal tubular-specific overexpression of the Cyp4a12-20-HETE synthase promotes salt-sensitive hypertension in male mice. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. July 2020.
Garcia V, Park EJ, Siragusa M, Frohlich F, Mahfuzul M, Pascale JV, Heberlein KR, Isakson BE, Stuehr DJ, and Sessa WC. Unbiased proteomics identifies plasminogen activator inhibitor-1 (PAI-1) is a negative regulator of endothelial nitric oxide synthase (eNOS). Proceedings of the National Academy of Sciences PNAS. April 2020.
Dakarapu R, Errabelli R, Manthati VL, Adebesin AM, Barma DK, Barma D, Garcia V, Zhang F, Schwartzman ML, and Falck JR. 19-Hydroxyeicosatetraenoic acid analogs: Antagonism of 20-Hydroxyeicosatetraenoic acid-induced vascular sensitization and hypertension. Bioorganic and Medicinal Chemistry Letter. August 2019
Li C, Tang S, Zhang F, Garcia V, Falck JR, Schwartzman ML, Arbad A, and Guo A. CYP4A/20-HETE Axis Regulates Ischemia-induced Neovascularization via Its Actions on Endothelial Progenitor and Preexisting Endothelial Cells. AJP-Heart and Circulatory Physiology. April 2019
Garcia V and William C. Sessa. Endothelial Nitric Oxide Synthase (eNOS): Perspective and Recent Developments. British Journal of Pharmacology. October 2018
Gilani A, Pandey V, Garcia V, Agostinucci K, Singh S, Schragenheim J, Bellner L, Falck JR, Paudyal M, Capdevila J, Abraham N, and Schwartzman ML. High fat diet-induced obesity and insulin resistance in Cyp4a14-/- mice is mediated by 20-HETE. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. August 2018
Pandey V, Garcia V, Gilani A, Mishra P, Zullo J, Jiang H, Falck JR, Nasjletti A, and Schwartzman ML. The blood pressure lowering effect of 20-HETE blockade in Cyp4a14 (-/-) mice is associated with natriuresis. Journal of Pharmacology and Experimental Therapeutics. December 2017
Garcia V, Gilani A, Shkolnik B, Pandey V, Zhang F, Dakarapu R, Gandham SK, Reddy R, Graves JP, Gruzdev A, Zeldin D, Capdevila J, Falck JR, and Schwartzman ML. 20-HETE signals through G protein-coupled receptor GPR75 (Gq) to affect vascular function and trigger hypertension. Circulation Research. June 2017
Garcia V, and Schwartzman ML Recent developments on the vascular effects of 20-hydroxyeicosatetraenoic acid. Current Opinion in Nephrology and Hypertension. February 2017.
Dordea A, Vandenwijngaert S, Garcia V, Tainsh R, Nathan D, Allen K, Raher M, Tainsh L, Zhang FF, Lieb W, Mikelman S, Kirby A, Stevens C, Thoonen R, Hindle A, Sips P, Falck JR, Daly M, Brouckaert P, Bloch P, Malhotra, Schwartzman ML, Buys E, and Bloch D. Androgen-sensitive hypertension associated with soluble guanylate cyclase alpha1 deficiency is mediated by 20-HETE. AJP-Heart and Circulatory Physiology. June 2016.
Garcia V, Shkolnik B, Milhau L, Falck JR, and Schwartzman ML. 20-HETE activates the transcription of angiotensin converting enzyme (ACE) via NF-kB translocation and promoter binding. Journal of Pharmacology and Experimental Therapeutics. March 2016
Garcia V, Joseph G, Shkolnik B, Ding Y, Zhang F, Gotlinger K, Bernstein KE, Falck JR, Dakarapu R, Capdevila J, and Schwartzman ML. Angiotensin II receptor blockade or deletion of vascular endothelial ACE does not prevent vascular dysfunction and remodeling in 20-HETE-dependent hypertension. Accepted/Final Revisions. American Journal of Physiology: Regulatory, Integrative, and Comparative Physiology. April 2015.
Hoopes SL, Garcia V, Edin ML, Schwartzman ML, and Zeldin, DC. Vascular actions of 20-HETE. Review. Prostaglandins and Other Lipid Mediators (POLM). February 2015
Garcia V, Cheng J, Weidenhammer A, Ding Y, Wu CC, Zhang F, Gotlinger K, Falck JR, and Schwartzman ML. Androgen-induced hypertension in angiotensinogen deficient mice: Role of 20-HETE and EETs. Prostaglandins and Other Lipid Mediators (POLM). December 2014
Gangadhariah MH, Luther JM, Garcia V, Paueksakon P, Hayward S, Love HD, Falck JR, Manthati VL, Imig JD, Schwartzman ML, Zent R, Capdevila JH, and Pozzi A. Hypertension is a major contributor of 20-hydroxyeicosatetraenoic acid-mediated kidney injury in diabetic Cyp4a14-null male mice. Journal of the American Society of Nephrology (JASN). June 2014
Cheng J, Edin ML, Li H, Bradbury JA, Graves JP, DeGraff LM, Lih FB, Garcia V, Shaik JSB, Tomer KB, Falck JR, Lee CR, Poloyac SM, and Schwartzman ML, Zeldin DC. Vascular characterization of mice with endothelial expression of Cytochrome P450 4F2. The FASEB Journal. March 2014
Ding Y, Wu CC, Garcia V, Dimitrova I, Weidenhammer A, Joseph G, Zhang F, Manthati VL, Falck JR, Capdevila JH, and Schwartzman 20-HETE induces remodeling of renal resistance arteries independent of blood pressure elevation in hypertension. American Journal of Physiology: Renal Physiology July 2013
Wu CC, Mei, S, Cheng J, Ding Y, Weidenhammer A, Garcia V, Zhang F, Gotlinger K, Manthati VL, Falck JR, Capdevila JH, and Schwartzman M.L. Androgen-Sensitive Hypertension Associates with Upregulated Vascular Cyp4a12-20-HETE Synthase. Journal of the American Society of Nephrology. May 2013
Wu CC, Gupta T, Garcia V, Ding Y, and Schwartzman ML. 20-HETE and Blood Pressure Regulation: Clinical Implications. Cardiology in Review. April 2013
Cheng J, Garcia V, Ding Y, Wu CC, Thakar K, Falck JR, Ramu E, and Schwartzman M.L.(2012) Induction of Angiotensin-Converting Enzyme and Activation of the Renin-Angiotensin System Contributes to 20-Hydroxyeicosatetranoic Acid-Mediated Endothelial Dysfunction. Atherosclerosis, Thrombosis, and Vascular Biology. Aug 2012
Remond MC, Iaffaldano G, O’Quinn MP, Mezentseva NV, Garcia V, Harris BS, Gourdie RG, Eisenberg CA, and Eisenberg LM. (2011). GATA6 reporter gene reveals myocardial phenotypic heterogeneity that is related to variations in gap junction coupling. American Journal of Physiology: Heart and Circulatory Physiology. Sep 2011
