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Sachin Gupte, M.D., Ph.D., Awarded $2.7 Million NIH Grant to Develop Treatments for Vascular Disease

Research Will Focus On Pulmonary Arterial Hypertension (PAH), PAH-induced Heart Failure And Metabolic Syndrome-associated Coronary Artery Disease

February 06, 2023
Sachin Gupte, M.D., Ph.D.
Sachin Gupte, M.D., Ph.D.

The Gupte laboratory has recently discovered that two isoenzymes of glucose-6-phosphate dehydrogenase (G6PD) are expressed in the vascular smooth muscle (VSM) and that G6PD-derived NADPH (pyridine nucleotide) signaling plays a role in mediating VSM contraction and switching VSM cell from contractile to synthetic phenotype.

The grant proposes to determine potential mechanisms, driven by a newly discovered G6PD isoform in the nucleus of vascular smooth muscle cells (VSMCs), that contribute to pathogenic large artery stiffness and remodeling.

“We anticipate the results of this project will reveal the direct link between G6PD and gene expression that contribute to vascular pathology and expose mechanisms for disparate vascular disease outcomes observed in different ethnic groups around the world,” said Dr. Gupte.