The Holz Lab is broadly interested in mTOR and nuclear receptor signaling in health and disease. mTOR, the mechanistic target of rapamycin, is a protein kinase that senses many extracellular signals to control anabolic processes leading to cell growth and proliferation. mTOR is inappropriately activated in many diseases, including cancer. Our goal is to understand the role of mTOR in diseases that depend on the hormone estrogen, such as breast cancer and a rare lung disease called lymphangioleiomyomatosis (LAM).
Join our group! We are seeking enthusiastic postdoctoral fellows. Requirements for this position are a recent Ph.D. in cancer biology, molecular biology, cell biology, biochemistry, or a similar field. We are looking for candidates with a background in signal transduction and/or nuclear receptor biology. This project will study the crosstalk between estrogen and mTOR signaling in normal cells and in proliferative diseases and will integrate a variety of approaches. A successful candidate would have experience in one or more areas, such as transcription factor biology, signaling, breast cancer biology and/or phosphoproteomics. The fellow will be expected to work independently and as part of a team, take initiative, apply for extramural fellowships, and will have the opportunity to develop new projects in their area of interest. Qualified candidates should send their cover letter and CV to Marina K. Holz, Ph.D., M.P.H., dean of the Graduate School of Biomedical Sciences and professor of cell biology and anatomy.