Daohong Lin, M.D., Ph.D., joined Dr. Wenhui Wang’s lab in the Department of Pharmacology at NYMC as a research fellow in 2000 when she was a second-year Ph.D. student at Harbin Medical University, China. Her long-standing research interest has been focused on studying the regulation of inwardly rectifying potassium channels (Kir) in epithelial cells.
During her post-doctoral training in Dr. Wang’s lab in 2005, Dr. Daohong studied the regulation of ROMK channel (Kir1.1), a key K channel for renal K secretion in the kidney. She has used molecular, protein chemistry, and electrophysiology approaches to study the roles of protein kinases, ubiquitination, and microRNA in mediating the effect of dietary K intake on ROMK channels. Additionally, she has observed that low K intake stimulated the ROMK ubiquitination and that protein tyrosine kinase inhibited ROMK by increasing ROMK internalization. After receiving the Scientific Development Grant from the American Heart Association in 2011, Dr. Daohong was appointed as a tenure-track assistant professor in the Department of Pharmacology at NYMC. Since becoming an independent faculty member, Dr. Daohong’s research has focused on the regulation of Kir5.1(Kcnj16) on Kir4.1 (Kcnj10) channels in the kidney and has received NIH R01 funding in 2017 and 2023.
Education
- M.D., Clinical Medicine, Harbin Medical University
- Ph.D., Pharmacology, Harbin Medical University/New York Medical College
- M.S., Microbiology, Harbin Medical University
Areas of Expertise
- Renal Physiology
Research
- Regulation of Kir4.1/Kir5.1 and renal potassium excretion
Publications
- Duan XP, Zheng JY, Zhang C, Alam S, Wang WH, Lin DH. Mechanistic target of rapamycin complex-2 (mTORc2) mediates the effect of over-night high K(+) on Kir4.1/Kir4.1 in the DCT and ENaC/ROMK in ASDN. Am J Physiol Renal Physiol. 2025 Nov 5;. doi: 10.1152/ajprenal.00291.2025. [Epub ahead of print] PubMed PMID: 41191079; NIHMSID:NIHMS2122566.
- Xiao Y, Duan XP, Zhang CB, Wang WH, Lin DH. Mechanistic Target of Rapamycin Complex 1 in Distal Convoluted Tubule and Renal Potassium Handling. J Am Soc Nephrol. 2025 Oct 1;36(10):1902-1913. doi: 10.1681/ASN.0000000727. Epub 2025 May 21. PubMed PMID: 40397537; PubMed Central PMCID: PMC12499621.
- Zhang CB, Ding Z, Duan XP, Chowdhury T, Wang WH, Lin DH. Kir5.1 regulates Kir4.2 expression and is a key component of the 50-pS inwardly rectifying potassium channel in basolateral membrane of mouse proximal tubules. Am J Physiol Renal Physiol. 2025 Feb 1;328(2):F248-F257. doi: 10.1152/ajprenal.00178.2024. Epub 2025 Jan 2. PubMed PMID: 39745541; PubMed Central PMCID: PMC12207947.
- Duan XP, Zheng JY, Xiao Y, Zhang CB, Lin DH, Wang WH. Angiotensin II-Type-1a Receptor and Renal K + Wasting during Overnight Low-Na + Intake. J Am Soc Nephrol. 2024 Nov 1;35(11):1478-1492. doi: 10.1681/ASN.0000000000000429. Epub 2024 Jun 24. PubMed PMID: 38913434; PubMed Central PMCID: PMC11543017.
- Duan XP, Zhang CB, Wang WH, Lin DH. Role of calcineurin in regulating renal potassium (K(+)) excretion: Mechanisms of calcineurin inhibitor-induced hyperkalemia. Acta Physiol (Oxf). 2024 Aug;240(8):e14189. doi: 10.1111/apha.14189. Epub 2024 Jun 11. Review. PubMed PMID: 38860527; PubMed Central PMCID: PMC11250626.
- Duan XP, Zheng JY, Jiang SP, Wang MX, Zhang C, Chowdhury T, Wang WH, Lin DH. mTORc2 in Distal Convoluted Tubule and Renal K + Excretion during High Dietary K + Intake. J Am Soc Nephrol. 2024 Sep 1;35(9):1149-1163. doi: 10.1681/ASN.0000000000000406. Epub 2024 May 24. PubMed PMID: 38788191; PubMed Central PMCID: PMC11387030.
- Zhang DD, Duan XP, Mutig K, Rausch F, Xiao Y, Zheng JY, Lin DH, Wang WH. Calcineurin inhibitors stimulate Kir4.1/Kir5.1 of the distal convoluted tubule to increase NaCl cotransporter. JCI Insight. 2023 Apr 10;8(7). doi: 10.1172/jci.insight.165987. PubMed PMID: 36821372; PubMed Central PMCID: PMC10132170.
Professional Service
- Editorial Board Member, AJP-Renal Physiology
- Editorial Board Member, Frontiers in Physiology Renal Epithelial and Transports
Memberships and Affiliations
- American Physical Society (APS)
Teaching Responsibilities
- PSE
- Pharmacology
