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Professor, Cell and Molecular Physiology & Cell and Molecular Physiology – Division of NeuroscienceNew York Medical College - Biomedical SciencesProfessor, Cell and Molecular Physiology & Cell and Molecular Physiology – Division of NeuroscienceProfessor, NeurologyNew York Medical College - School of Medicine

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Education

  • Ph.D., Pharmacology, Uniformed Services University of the Health Sciences
  • B.S., Natural Sciences, Johns Hopkins University
  • Post-Graduate Studies, Neurophysiology, Max Planck Institute for Psychiatry
  • Post-Graduate Studies, Biophysics, The Johns Hopkins University 

Areas of Expertise

  • Traumatic Brain Injury
  • Seizure Research

Honors and Awards

  • Alexander von Humboldt Foundation Fellow
  • Klingenstein Fellow in the Neurosciences
  • Office of Naval Research Young Investigator Award
  • American Physiological Society Frontiers in Physiology Investigator

Research

Dr. Stanton's lab is investigating the cellular mechanisms underlying neuronal plasticity, including: 1) properties of long-term activity-dependent potentiation (LTP) and depression (LTD) of synaptic strength; 2) links between biochemical signaling cascades underlying LTD and LTP; 3) changes in synaptic function and structure associated with Alzheimer’s disease, traumatic brain injury, depression, stroke, migraine headache, perinatal lead exposure, and the development of epileptic seizures; and 4) cellular mechanisms that both trigger and prevent ischemia-induced delayed neuronal death.

They were the first to show that induction of mammalian LTP requires cyclic AMP and new protein synthesis, to characterize a form of LTD evoked when presynaptic inputs are active while postsynaptic neurons are hyperpolarized, and to discover that traumatic brain injury and chronic depression are associated with long-lasting damage to neuronal and axonal structure and impairments in long-term synaptic plasticity, which can be reversed by new drug treatments that they have developed that are now in clinical trials. His lab discovered a bidirectional cyclic nucleotide regulation of synaptic strength, chemical methods of inducing this and other forms of LTD, and pioneered the direct two-photon fluorescence imaging of presynaptic transmitter release to demonstrate that this form of LTD persistently alters the presynaptic transmitter release apparatus and glutamate release from the rapidly-recycling pool of transmitter vesicles. They employ extracellular and whole-cell patch clamp recordings, two-photon excitation, and confocal fluorescence imaging of functional synaptic networks in both acute in vitro slices and organotypic slice cultures from hippocampus and medial prefrontal neocortex.

Publications

  • Stanton PK. "Noradrenergic modulation of epileptiform bursting and synaptic plasticity in the dentate gyrus." Epilepsy research. Supplement, 7(), (1992) 135-50.
  • Stanton PK, Mody I, Zigmond D, et. al. "Noradrenergic modulation of excitability in acute and chronic model epilepsies." Epilepsy research. Supplement, 8(), (1992) 321-34.
  • Sperber EF, Stanton PK, Haas K, et. al. "Developmental differences in the neurobiology of epileptic brain damage." Epilepsy research. Supplement, 9(), (1992) 67-80; discussion 80-1.
  • Haring R, Stanton PK, Scheideler MA, et. al. "Glycine-like modulation of N-methyl-D-aspartate receptors by a monoclonal antibody that enhances long-term potentiation." Journal of neurochemistry, 57(1), (1991) 323-32.
  • Stanton PK, Chattarji S, Sejnowski TJ, et. al. "2-Amino-3-phosphonopropionic acid, an inhibitor of glutamate-stimulated phosphoinositide turnover, blocks induction of homosynaptic long-term depression, but not potentiation, in rat hippocampus." Neuroscience letters, 127(1), (1991) 61-6.
  • Sperber EF, Haas KZ, Stanton PK, et. al. "Resistance of the immature hippocampus to seizure-induced synaptic reorganization." Brain research. Developmental brain research, 60(1), (1991) 88-93.
  • Stanton PK, Moskal JR. "Diphenylhydantoin protects against hypoxia-induced impairment of hippocampal synaptic transmission." Brain research, 546(2), (1991) 351-4.
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Professional Service

  • Editor-in-Chief, NeuroReport
  • Editor-in-Chief, Journal of Bioenergetics & Biomembranes
  • NIH External Advisory Committee, University of New Mexico Center for Brain Recovery and Repair
  • Member, Society for Neuroscience, International Brain Research Organization, New York Academy of Sciences, Society for Toxicology, Union of Concerned Scientists

Teaching Responsibilities

  • Cellular Mechanisms of Learning and Memory
  • Medical Neuroscience