NYMC > Faculty > Faculty Profiles > By Name > Etlinger, Joseph

Joseph D. Etlinger, Ph.D.


Professor and Chair of Cell Biology and Anatomy

Email: joseph_etlinger@nymc.edu
Phone: (914) 594-4028

Department of Cell Biology & Anatomy
Basic Sciences Building
Valhalla, NY 10595


  • B.S., Physics, Rensselaer Polytechnic Institute
  • Ph.D., Biophysics, University of Chicago
  • Postdoctoral Fellowship, Physiology and Biochemistry, Harvard Medical School


  • Established Investigator of the American Heart Association
  • Irma T. Hirschl Award, Principal Investigator on grants from NIH, NASA and MDA


With Alfred L. Goldberg, Dr. Etlinger discovered non-lysosomal ATP-dependent proteolytic activity, credited by awardees of the 2004 Nobel Prize in chemistry, as the seminal observation revealing the proteasome/ubiquitin system. In subsequent studies, with his students and colleagues, novel factors involved in the regulation of this pathway including a ubiquitin ligase critical to pulmonary arterial hypertension were identified. Dr. Etlinger proposed how myofibrils turnover during muscle growth and atrophy and the roles of calcium, ATP, and beta-adrenergic receptors in these conditions. Finally, he identified modalities to improve recovery from spinal cord injury including beta-agonists, x-irradiation, and inhibitors of glucose toxicity.


  • Zeman RJ, Wen X, Ouyang N, et. al. "Role of the Polyol Pathway in Locomotor Recovery and Wallerian Degeneration after Spinal Cord Contusion Injury." Neurotrauma reports, 2(1), (2021) 411-423. doi: 10.1089/neur.2021.0018
  • Sehgal PB, Westley J, Lerea KM, et. al. "Biomolecular condensates in cell biology and virology: Phase-separated membraneless organelles (MLOs)." Analytical biochemistry, 597(), (2020) 113691. doi: 10.1016/j.ab.2020.113691
  • Zeman RJ, Wen X, Moorthy CR, et. al. "Therapeutic target for external beam x-irradiation in experimental spinal cord injury." Journal of neurosurgery. Spine, (), (2020) 1-8. doi: 10.3171/2019.11.SPINE19305
  • Murakami K, Etlinger JD. "Role of SMURF1 ubiquitin ligase in BMP receptor trafficking and signaling." Cellular signalling, 54(), (2019) 139-149. doi: 10.1016/j.cellsig.2018.10.015
  • Etlinger JD. "An Exciting Couple." Journal of pediatric ophthalmology and strabismus, 55(3), (2018) 149-150. doi: 10.3928/01913913-20180409-04
  • Brown A, Nabel A, Oh W, et. al. "Perfusion imaging of spinal cord contusion: injury-induced blockade and partial reversal by β2-agonist treatment in rats." Journal of neurosurgery. Spine, 20(2), (2014) 164-71. doi: 10.3171/2013.10.SPINE13113
  • Murakami K, Mathew R, Huang J, et. al. "Smurf1 ubiquitin ligase causes downregulation of BMP receptors and is induced in monocrotaline and hypoxia models of pulmonary arterial hypertension." Experimental biology and medicine (Maywood, N.J.), 235(7), (2010) 805-13. doi: 10.1258/ebm.2010.009383

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  • Medical Cell Biology and Anatomy
  • Graduate Histology and Graduate Cell Biology
  • Dental Histology
  • Cell Biology Topics
  • Journal Club