NYMC > Faculty > Faculty Profiles > By Name > Etlinger, Joseph

Joseph D. Etlinger, Ph.D.

Professor and Chairman of Cell Biology and Anatomy

Email: joseph_etlinger@nymc.edu

Department of Cell Biology & Anatomy
Basic Sciences Building
Valhalla, NY 10595

With Alfred L. Goldberg, I discovered non-lysosomal ATP-dependent proteolytic activity, credited by awardees of the 2004 Nobel Prize in chemistry, as the seminal observation revealing the proteasome/ubiquitin system. In subsequent studies, with my students and colleagues, we identified novel factors involved in the regulation of this pathway including a ubiquitin ligase critical to pulmonary arterial hypertension. We proposed how myofibrils turnover during muscle growth and atrophy and the roles of calcium, ATP, and beta-adrenergic receptors in these conditions. Finally, we have identified modalities to improve recovery from spinal cord injury including beta-agonists, x-irradiation, and inhibitors of glucose toxicity.

Courses Taught: Medical Cell Biology and Anatomy, Graduate Histology and Graduate Cell Biology, Dental Histology, Cell Biology Topics and Journal Club

Honors and Awards:

  • Established Investigator of the American Heart Association
  • Irma T. Hirschl Award, Principal Investigator on grants from NIH, NASA and MDA

Professional Interests:

Research interests include skeletal muscle growth and atrophy, molecular mechanisms, and selectivity of intracellular proteolysis in erythroid and muscle cells; role of proteasomes and ubiquitin; spinal cord injury; pulmonary hypertension.


  • Post Graduate Studies: Postdoctoral Fellowship in Physiology and Biochemistry, Harvard Medical School
  • Graduate Degree: Ph.D. in Biophysics, University of Chicago
  • Undergraduate Degree: B.S. in Physics, Rensselaer Polytechnic Institute

Selected Bibliography: