Department of Cell Biology & Anatomy
Basic Sciences Building
Valhalla, NY 10595
With Alfred L. Goldberg, I discovered non-lysosomal ATP-dependent proteolytic activity, credited by awardees of the 2004 Nobel Prize in chemistry, as the seminal observation revealing the proteasome/ubiquitin system. In subsequent studies, with my students and colleagues, we identified novel factors involved in the regulation of this pathway including a ubiquitin ligase critical to pulmonary arterial hypertension. We proposed how myofibrils turnover during muscle growth and atrophy and the roles of calcium, ATP, and beta-adrenergic receptors in these conditions. Finally, we have identified modalities to improve recovery from spinal cord injury including beta-agonists, x-irradiation, and inhibitors of glucose toxicity.
Courses Taught: Medical Cell Biology and Anatomy, Graduate Histology and Graduate Cell Biology, Dental Histology, Cell Biology Topics and Journal Club
Honors and Awards:
Research interests include skeletal muscle growth and atrophy, molecular mechanisms, and selectivity of intracellular proteolysis in erythroid and muscle cells; role of proteasomes and ubiquitin; spinal cord injury; pulmonary hypertension.