NYMC > Faculty > Faculty Profiles > By Name > Mathew, Rajamma

Rajamma Mathew M.D.

Research Professor of Pediatrics
Research Professor of Physiology


Section of Pediatric Cardiology
Dept of Pediatrics 
Rm A11
Basic Science Building
New York Medical College
Valhalla, NY 10595

Trained in Pediatric Cardiology
Currently involved in basic science research in pulmonary hypertension (80%) and patient care (20%)

Professional Interests:

Congenital Heart defect, pulmonary circulation and pulmonary hypertension.

Selected Publications:

Mathew R. Pathogenesis of pulmonary hypertension: a case for caveolin-1 and cell membrane integrity. 2013 Am J Physiol Heart Circ Physiol (e-pub, PMID 24163076) 

Dereddy N, Huang J, Erb M, Guzel S, Wolk JH, Sett SS, Gewitz MH,Mathew R. Associated inflammation or increased flow-mediated shear stress, but not the pressure alone disrupts endothelial caveolin-1 in infants with pulmonary hypertension. Pulm Circ 2012; 2:492-500. 

Huang J, Wolk JH, Gewitz MH. Mathew R.  Caveolin-1 expression during the progression of pulmonary hypertension. Exp Biol Med2012; 237:856-865.

Mathew R. PDGF Receptor Blocker for Pulmonary Hypertension: A New Agent in Therapeutic   Arsenal. Expert Opin Invest Drugs. 2012; 21:139-142.

Mathew R. Gene therapy for pulmonary arterial hypertension: Is a cure in sight? Expert Opin. Biol. Ther. 2011; 11:129-131.

Mathew R. Pulmonary hypertension: current therapy and future prospects. Cardiovas Hematol Agents Medicinal Chem 2011; 9:165-182.
Mathew R. Cell-specific dual role of caveolin-1 in pulmonary hypertension (Invited Review) Pulm Med 2011 Pulm. Med. 2011; 2011:573432

Mathew R, Huang J, Katta UD, Krishnan U, Sandoval C, Gewitz MH. Immunosuppressant- induced endothelial damage and pulmonary arterial hypertension. J Pediatr Hematol Oncol 33:55-58, 2011

Mathew R. Gene therapy for pulmonary arterial hypertension. Is a cure in sight?
Expert Opin Biol  Ther (Invited Editorial) 11:129-131, 2011

Murakami K, Mathew R, Huang J, Farahami R, Peng H, Olson SC, Etlinger JD. Smurf-1 ubiquitin ligase causes downregulation of BMP receptors and is induced in monocrotaline and hypoxia models of pulmonary arterial hypertension. Expt Biol Med 2010; 235:805-813.

Mathew R. Inflammation and Pulmonary Hypertension (Invited Review) Cardiology in Review 18:67-72, 2010.

Huang J, Wolk J, Gewitz MH, Mathew R. Progressive Endothelial Cell Damage in an Inflammatory Model of Pulmonary Hypertension. Expt Lung Res 36:57-66, 2010

Ciszar A, Labinsky N, Zhao X, Gupte SA, Wu JM, Mathew R, Wolin MS, Ungvari Z. Reseveratrol prevents monocrotaline-induced pulmonary hypertension in rats. Hypertension  54:668-675, 2009.

Mathew R. NO-Independent Activators of Soluble Guanylate Cyclase: Therapeutic Potential. Am J Hypertension Am J Hypertension 227:470, 2009.

Gupte S, Kaminski PM, George S, Luba K, Olson SC, Mathew R, Hintze TH, Wolin MS. NADPH oxidase isoform-2 (Nox-2)-derived reactive oxygen species mediate PKC-induced vascular contraction. (AJP heart crc 296:h1048-h1057,  2009

Huang J, Kaminski PM, Edwards JG, Yeh A, Wolin MS, Frishman WH, Gewitz MH. Mathew R. Pyrrolidine Dithiocarbamate Restores Endothelial Cell Membrane Integrity and Attenuates Monocrotaline-Induced Pulmonary Artery Hypertension Am J Physiol (LCMP), 2008 April 4, 294: (L-1250-9)

Mathew R, Huang J, Gewitz MH. Pulmonary Hypertension: caveolin-1 and eNOS Interrelationship: a new perspective. Cardiology in Review.2007, 15:143-149.

Mathew R, Huang J, Shah M, Patel. K, Gewitz MH, Sehgal PB. Disruption of endothelial-cell caveolin-1/raft scaffolding during development of monocrotaline-induced pulmonary hypertension.  Circulation 110:1499-1506, 2004.

Mathew R, N. Yuan, L. Rosenfeld, M. H. Gewitz and  A. Kumar. 2002. Effects of Monocrotaline on eNOS expression and sulfhydryl  levels in rat lungs, Heart Disease:4:152-158.

Mathew R. and M.H. Gewitz  2000. Pulmonary hypertension in infancy and childhood. Heart Disease 2:362-368.

Mathew R. N-Y T Fan, N.Yuan, P.N. Chander, M.H. Gewitz and C.T. Stier Jr. 2000. Inhibition of nitric oxide synthase enhances pulmonary vascular changes in stroke-prone spotaneously hypertensive rats. Am J Physiol  278:L81-L89.

Bhargava A., A. Kumar, N.Yuan, M.H. Gewitz and R. Mathew. 1999. Monocrotaline induces IL6 mRNA expression in rat lungs. Heart Disease 1:126-132.

Mathew R., E.S. Gloster, T.S. Rajan, G. Zeballos and M.H. Gewitz. 1997. Exogenous nitric oxide attenuates monocrotaline-induced pulmonary hypertension in rats. J Appl Physiol 82:1493-1498.

Mathew R., H.A. Omar, W.Q. Shen, J. Wang, T.H. Hintze and M.S. Wolin. 1996. ANF modulates rexeptor-mediated cAMP-dependent responses in canine pulmonary artery during heart failure. Br J Pharmacol 116:1886-1890.
Mathew R., G.  Zeballos, H. Tun and M.H. Gewitz . 1995 Role of nitric oxide and endothelin 1 imbalance in monocrotaline-induced pulmonary hypertension in rats. Cardiovasc Res 30:739-746.

Mathew R., S. Colt and M.H. Gewitz. 1994. Nitric oxide production is impaired in rat pulmonary artery during pulmonary hypertension. Biology of Nitric Oxide Vol 3_353-356.

Mathew R., J. Wang, M.H. Gewitz, T.H. Hintze and M.S. Wolin. 1993. Congestive heart failure alters receptor-dependent cAMP-mediated relaxation of canine pulmonary arteries. Circulation87:1722-1728.

Mathew R., H.A. Omar, P.D. Cherry., M H. Gewitz and M.S. Wolin. 1992. Role of cGMP mechanisms in the responses to hypoxia in the rat pulmonary artery. Am J Physiol 32(1):H141-H146.

Mathew R, and B.M. Altura. 1992 The role of magnesium in lung diseases, Magnesium Trace Elements 19(2-4):220-228.

Book Chapters

Mathew R. Pathogenesis of pulmonary hypertension: in Pulmonary Hypertension (Chapter 3, pg   47-73). Editors: Elwing JM and Panos RJ. Publishers: Intech: 2013: ISBN 978-953-51-1165-8.  DOI:10.5772/56179

Mathew R. Pulmonary Hypertension: Endothelial cell Function. In Pulmonary hypertension: From Bench Research to Clinical Challenge (pp 1-24). Editors: Sulica R and Preston I. Publishers: Intech 2011: ISBN 978-953-307-835-9. DOI:10.5772/26198

Mathew R. , B.M. Altura. 1991. Pharmacology: Pulmonary Circulation. In Encyclopedia of Human Biology. Publishers: Academic Press. Vol 6:345-355.
Updated in 1997. .

Mathew R. 1991. Development of pulmonary circulation:  Metabolic aspects. In Fetal and Neonatal Physiology. Eds: R.A. Polin and W.W. Cox. Publishers: WB Saunders. Vol 1. Pages: Updated in 1997

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