New York Medical College
15 Dana Road
Basic Sciences Building (BSB), 107
Valhalla, NY 10595
Honors and Awards:
NIH Maximizing Investigators' Research Award (MIRA), 2020 -
Ruth L. Kirschstein National Research Service Award, 2016-2017
Postdoctoral Fellowship, BrightFocus Foundation for Alzheimer’s Disease Research, 2014-2016
Postdoctoral Grant Award, Chicago Biomedical Consortium 2014-2016
Postdoctoral Fellowship, National Ataxia Foundation, 2014
Jian Li completed his Ph.D. study in Dr. David Gilmour’s lab at Penn State University. His thesis work using biochemical and next-generation sequencing approaches uncovered mechanisms underlying promoter-proximal pausing of RNA polymerase II, an important regulatory step of eukaryotic transcription. Jian then moved to Dr. Rick Morimoto’s lab at Northwestern University for his postdoctoral training, where he started using the nematode C. elegans as a model. His work discovered the transcriptional program of HSF1, the key regulator of cellular heat shock response, in animal development independent of temperature stress. Jian established his own lab at Oklahoma Medical Research Foundation in 2017. His lab uses both animal and cellular models and combines genetics, cellular biology and multi-omics (functional genomics, transcriptomics, proteomics and metabolomics) to understand protein homeostasis (proteostasis) and stress response pathways in reproduction, aging and cancer. Jian joined the faculty of New York Medical College in 2022.
Selected Publications and Presentations:
Morphis AC, Edwards SL, Erdenebat P, Kumar L, Li J. “Auxin-Inducible Degron System Reveals Temporal-Spatial Roles of HSF-1 and Its Transcriptional Program in Lifespan Assurance. Front Aging. 2022;3:899744. PMID: 35899092; PMCID: PMC9309338.
Amici DR, Ansel DJ, Metz KA, Smith RS, Phoumyvong CM, Gayatri S, Chamera T, Edwards SL, O'Hara BP, Srivastava S, Brockway S, Takagishi SR, Cho BK, Goo YA, Kelleher NL, Ben-Sahra I, Foltz DR, Li J, Mendillo ML. C16orf72/HAPSTR1 is a molecular rheostat in an integrated network of stress response pathways. Proc. Natl. Acad. Sci. 2022 Jul 5;119(27). PMID: 35776542; PMCID: PMC9271168.
Edwards L.S, Erdenebat P, Morphis A.C., Kumar L, Wang L, Chamera T, Georgescu C, Wren J and Li J. “Insulin/IGF-1 signaling and heat stress differentially regulate HSF1 activities in germline development” Cell Reports. 2021, Aug.;36(9): 109623. PMID: 34469721; PMCID: PMC8442575
Li J, Labbadia, J, Morimoto, RI. “Rethinking HSF1 in Stress, Development, and Organismal Health” Trends Cell Biol. 2017, Dec.; 27 (12):895-905. Review. PMID: 28890254; PMCID: PMC5696061
Li J, Chauve L, Phelps G, Brielmann RM and Morimoto RI. “E2F co-regulates an essential HSF developmental program that is distinct from the Heat Shock Response” Gene & Development 2016, 30 (18), 2062-2075
Li J and Gilmour DS. “Distinct mechanisms of transcriptional pausing orchestrated by GAGA factor and M1BP, a novel transcription factor” EMBO J. 2013, 32(13): 1829-41
Li J, Liu Y, Rhee HS, Ghosh SK, Bai L, Pugh BF and Gilmour DS. “Kinetic Competition between Elongation Rate and Binding of NELF Controls Promoter-Proximal Pausing” Mol. Cell, 2013, 50(5): 711-22