Department of Physiology
Basic Sciences Building
Valhalla, NY 10595
My working field is focused on the gender specific regulation of endothelial function of arterioles via nitric oxide (NO)-dependent and independent mechanisms, as a function of shear stress, especially, the signaling cascades responsible for the estrogen-specific regulation of shear stress by a cytochrome P450-dependent mechanism. Experiments are mainly conducted on microvessels (~100-200 µm) isolated from skeletal muscle, mesentery and coronary vascular beds of rats and mice. The functional changes involving vasodilator and constrictor responses are assessed. Also, experiments aimed to clarify possible mechanisms are performed by using molecular (PT-PCT, Western) and biochemical (HPLC, GC-MS) analyses, and transfection methods (si RNA) in the isolated vessels.
Graduate Degree: M.D., Ph.D.
Graduate Degree Institution: ShangHai Second Medical College, China
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