Associate Professor of Pathology, Microbiology and Immunology
Contact
Education
Ph.D., Life Sciences, Devi Ahilya Vishwavidyalaya, Indore, India
Research
Dr. Jain’s laboratory strives to evaluate the contributions of genetic heterogeneity in pathological conditions associated with the cardiovascular-renal systems. In particular, they study single nucleotide polymorphisms in the renin-angiotensin-aldosterone (RAA) axis with an eye towards their impact in the genesis of hypertension; their long-term goal being to identify novel molecular targets in this pathway so as to facilitate the development of a "tailored" drug therapy for hypertension and associated pathologies. The laboratory has cloned and generated mice models of human angiotensinogen gene and its receptor hAT1R gene variants. We employ these animal models to dissect differential regulation of these target genes whose polymorphisms have been reported in the human population. Apart from blood pressure regulation, they have proposed the use of these animal models, with appropriate modifications, to better understand the role of genetic variants of human AT1R gene and RAA axis in contributing towards metabolic syndrome and susceptibility to respiratory infections.
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Memberships and Affiliations
Teaching Responsibilities