Email: dong_sun@nymc.edu
Address:
Department of Physiology
Basic Sciences Building
New York Medical College
Valhalla, NY 10595
Professional Interests:
My research is mainly focusing on the regulation of endothelial function of arterioles. In particular, endothelial compensatory mechanisms in response to an impaired endothelial nitric oxide (NO) signaling and endothelial deformation-induced initiation of NO-dependent vascular protective mechanisms are studied.
In recent years, I intensively focused my research on endothelial dysfunction of microvessels in response to vascular aging. Using isolated arterioles to assess flow-induced dilation and shear stress-induced release of NO, I demonstrated that age-associated endothelial dysfunction is characterized by an impaired NO bioavailability, due to a decreased shear stress-induced eNOS phosphorylation, an increased superoxide formation and a decreased antioxidant capacity. The increased superoxide formation in aged vessels is a consequence of eNOS uncoupling and increased expression of NADPH oxidase.
Education Profile:
Graduate Degree: M.D., Ph.D.
Graduate Degree Institution: XuZhou Medical College; New York Medical College.
Selected Bibliography:
Search PubMed for all available publications of Dong Sun, M.D., Ph.D.
