Professor of Pediatrics and Associate Professor of Physiology
Chairman, New York Medical College IRB
Associate Director of The Center for Hypotension
Address:
Suite 1600 South
19 Bradhurst Avenue
New York Medical College
Hawthorne, NY 10532
Professional Interests:
Pediatrics/Pediatric Gastroenterology, Hepatology and Nutrition
Postural Tachycardia Syndrome (POTS)
Hypotension
Syncope
Chronic Fatigue Syndrome (CFS)
DOD Gulf War Syndrome
Fibromyalgia
Chairman New York Medical College Institutional Review Board for the Protection of Human Subjects (NYMC IRB)
Research Profile:
Our investigational clinical interests involve the regulation of heart rate and blood pressure in children and adolescents. Circulatory physiology remains ill-determined in children with a variety of problems with neurovascular dysfunction. We have established a Center for Hypotension-Related Disease aimed at young people from childhood through young adult with neurally mediated syncope, chronic orthostatic intolerance, chronic fatigue syndrome, orthostatic intolerance of other etiologies such as occur in the postural tachycardia syndrome (POTS). Research focus is on circulatory and vascular problems and their autonomic consequences including altered peripheral arterial and venous properties and changes in blood volume and its redistribution. Molecular mechanisms including cytokine and nitric oxide assessment are explored. Treatment protocols are tested. Methods include plethysmographic measurements of peripheral and central blood flow, capacitance and peripheral permeability measurements, skin blood flow measurements using laser-Doppler flowmetry, baroreflex assessment, standard circulatory autonomic function tests, assessment of the efficacy of the skeletal muscle pump, and tests of heart rate and blood pressure variability. Orthostatic stress is used as a provocative stimulus.
Education Profile:
Post Graduate Studies: Physiology/Biophysics
Post Doctoral Studies: Biochemical Development and Molecular Diseases
Fellowship: Children’s Hospital of Philadelphia, Philadelphia PA
Graduate Degree: Ph.D.
Graduate Degree Institution: Cornell University Medical College
Undergraduate Degree: B.S. Biology
Undergraduate Institution: Lehman College (CUNY), Bronx, NY
Selected Bibliography:
Stewart JM, Pianosi P, Shaban MA, Terilli C, Svistunova M, Visintainer P and Medow MS. Postural Hyperventilation as a Cause of Postural Tachycardia Syndrome: Increased Systemic Vascular Resistance and Decreased Cardiac Output When Upright in All Postural Tachycardia Syndrome Variants. J Am Heart Assoc 7: 2018.
Stewart JM, Boris JR, Chelimsky G, Fischer PR, Fortunato JE, Grubb BP, Heyer GL, Jarjour IT, Medow MS, Numan MT, Pianosi PT, Singer W, Tarbell S and Chelimsky TC. Pediatric Disorders of Orthostatic Intolerance. Pediatrics 141: 2018.
Medow MS, Kothari ML, Goetz AM, O'Donnell-Smith MB, Terilli C and Stewart JM. Decreasing cerebral oxygen consumption during upright tilt in vasovagal syncope. Physiol Rep 5: 2017.
Medow MS, Merchant S, Suggs M, Terilli C, O'Donnell-Smith B and Stewart JM. Postural Heart Rate Changes in Young Patients With Vasovagal Syncope. Pediatrics 139: 2017.
Merchant S, Medow MS, Visintainer P, Terilli C and Stewart JM. Oscillatory lower body negative pressure impairs working memory task-related functional hyperemia in healthy volunteers. Am J Physiol Heart Circ Physiol 312: H672-H680, 2017.
Rowe PC, Underhill RA, Friedman KJ, Gurwitt A, Medow MS, Schwartz MS, Speight N, Stewart JM, Vallings R and Rowe KS. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Diagnosis and Management in Young People: A Primer. Front Pediatr 5: 121, 2017.
Stewart JM, Balakrishnan K, Visintainer P, Del Pozzi AT, Messer ZR, Terilli C and Medow MS. Oscillatory lower body negative pressure impairs task related functional hyperemia in healthy volunteers. Am J Physiol Heart Circ Physiol 310: H775-H784, 2016.
Medow MS, Del Pozzi AT, Messer ZR, Terilli C and Stewart JM. Altered oscillatory cerebral blood flow velocity and autoregulation in postural tachycardia syndrome. Front Physiol 5: 234, 2014.
Medow MS, Sood S, Messer Z, Dzogbeta S, Terilli C and Stewart JM. Phenylephrine alteration of cerebral blood flow during orthostasis: effect on n-back performance in chronic fatigue syndrome. J Appl Physiol (1985 ) 117: 1157-1164, 2014.
Medow MS, Aggarwal A, Baugham I, Messer Z and Stewart JM. Modulation of the axon-reflex response to local heat by reactive oxygen species in subjects with chronic fatigue syndrome. J Appl Physiol 114: 45-51, 2013.